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A thyrotropin-secreting pituitary adenoma as a cause of thyrotoxic periodic paralysis

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Abstract

We describe a patient with thyrotoxic periodic paralysis (TPP) caused by a thyrotropin-secreting pituitary adenoma. The diagnosis TPP was based on the combination of episodes of reversible hypokalaemic paralysis, hyperthyroidism and electrophysiological findings. A thyrotropin-secreting pituitary adenoma was diagnosed on the basis of endocrinological function tests and MRI of the pituitary gland. Before transsphenoidal resection of the adenoma, treatment with octreotide restored euthyroidism both clinically and biochemically. Immunocytochemistry of the pituitary adenoma was positive for TSH exclusively. Incubation with octreotide or quinagolide induced decreased TSH and α-subunit production by the cultured adenoma cells, in agreement with the preoperative in vivo data. This paper is the first to describe in vivo and in vitro characteristics of a thyrotropin-secreting pituitary adenoma in a patient presenting with periodic paralysis.

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References

  1. Beck-Peccoz P., Brucker-Davis F., Persani L., Smallridge R.C., Weintraub B. Thyrotropin-secreting pituitary tumors. Endocr. Rev. 17: 610, 1996.

    CAS  PubMed  Google Scholar 

  2. Bertherat J., Brue T., Enjalbert A., Gunz G., Rasolonjanahary R., Warnet A., Jaqet P., Epelbaum J. Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretion. J. Clin. Endocrinol. Metab. 75: 540, 1992.

    CAS  PubMed  Google Scholar 

  3. Orme S.M., Lamb J.T., Nelson M., Belchetz P.E. Shrinkage of thyrotropin-secreting pituitary adenoma treated with octreotide. Postgrad. Med. J. 67: 466, 1991.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Okinaka S., Shizume K., Iino S., Watanabe A., Irie M., Noguchi A., Kuma S., Kuma K., Ito T. The association of periodic paralysis and hyperthyroidism in Japan. J. Clin. Endocrinol. Metab. 17: 1454, 1957.

    Article  CAS  PubMed  Google Scholar 

  5. Kiso Y., Yoshida K., Kaise K., Kaise N., Masuda T., Ando N., Kameyama M., Yamamoto M., Sakurada T., Yoshinaga K. A case of thyrotropin (TSH)-secreting tumor complicated by periodic paralysis. J. Jpn. Med. 29: 399, 1990.

    Article  CAS  Google Scholar 

  6. Hoeven J.H. van der, Links T.P., Zwarts M.J., Weerden T.W. van. Muscle fiber conduction velocity in the diagnosis of familial hypokalemic periodic paralysis. Muscle Nerve 17: 898, 1994.

    Article  PubMed  Google Scholar 

  7. Kwekkeboom D.J., de Jong F.H., Lamberts S.W. Confounding factors in the interpretation of gonadotropin and gonadotropin-subunit release from cultured human pituitary adenomas. J. Steroid Biochem. 33: 111, 1989.

    Article  Google Scholar 

  8. Kelley D.E., Gharib H., Kennedy F.P., Duda R.J., McManis P.G. Thyrotoxic periodic paralysis. Report of 10 cases and review of electromyographic findings. Arch. Intern. Med. 149: 2597, 1989.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Academical Medical Center of the University of Amsterdam F5-171, PO Box 22660, 1100 DO, Amsterdam, The Netherlands

    A. M. W. Alings, Eric Fliers M.D. & W. M. Wiersinga

  2. Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, The Netherlands

    W. W. de Herder & L. J. Hofland

  3. Department of Internal Medicine, Deventer Ziekenhuizen, Deventer, The Netherlands

    H. E. Sluiter

  4. Department of Endocrinology, University Hospital Groningen, Groningen, The Netherlands

    T. P. Links

  5. Department of Neurology, University Hospital Groningen, Groningen, The Netherlands

    J. H. van der Hoeven

Authors
  1. A. M. W. Alings
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  2. Eric Fliers M.D.
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  3. W. W. de Herder
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  4. L. J. Hofland
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  5. H. E. Sluiter
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  6. T. P. Links
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  7. J. H. van der Hoeven
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  8. W. M. Wiersinga
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Alings, A.M.W., Fliers, E., de Herder, W.W. et al. A thyrotropin-secreting pituitary adenoma as a cause of thyrotoxic periodic paralysis. J Endocrinol Invest 21, 703–706 (1998). https://doi.org/10.1007/BF03350802

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  • DOI: https://doi.org/10.1007/BF03350802

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