Abstract
This study sought to determine the outcome of pregnancy in female patients with differentiated thyroid carcinoma who became pregnant after radioactive iodide treatment. A total of 779 female thyroid cancer patients were treated at Chang Gung Medical Center in Linkou between January 1977 and December 1995. The medical records of these patients were reviewed retrospectively. Thirty-seven of these patients had well differentiated thyroid carcinoma receiving 131I treatment and conceived at a mean age of 27.97±3.49 year-old. A total of 58 pregnancy episodes were recorded during this study period. Among these 37 patients, 3 episodes of artificial abortion, 8 episodes of spontaneous abortion and 2 threatened abortions were observed. These patients delivered a total of 47 babies including 3 premature babies. Seven of these patients conceived within 6 months after the last administration of 131I, including 2 cases within 1 month, 4 cases within 4 months, and 1 patient within 5 months. Of these 7 patients, only one patient who conceived within 6 months after the last administration of 131I (14.3%) had a spontaneous abortion. The present results suggest that previous administration of 131I in female patients with well differentiated thyroid cancer does not result in demonstrable adverse effects in subsequent pregnancies. However, further studies involving long-term follow-up of children delivered by mothers who became pregnant within 6 months after the last administration of 131I is needed to further elucidate the possible chronic effects and sequelae of 131I therapy on subsequent pregnancies.
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Samaan N.A., Maheshwari Y.K., Nader S., Hill C.S., Schultz P.N., Haynie T.P., Hickey R.C., Clark R.L., Goepfert H., Ibanez M.L., Litton C.E. Impact of therapy for differentiated carcinoma of the thyroid: an analysis of 706 cases. J. Clin. Endocrinol. Metab. 56: 1131, 1983.
DeGroot L.J. Thyroid neoplasia. Endocrinology, 3rd edition. W.B. Saunders, Philadelphia, 1995, p. 834.
Lin J.D., Huang M.J., Huang B.Y., Huang H.S., Jeng L.B. Thyroid cancer treated in Chang Gung Memorial Hospital (Northern Taiwan), during the period: 1979–1992: Clinical presentation, pathological finding, analysis of prognostic variables and results of treatment. J. Surg. Oncol. 57: 244, 1994.
Beierwaltes W.H., Rabbani R., Dmuchowski C., Lloyd R.V., Eyre P., Mallette S. An analysis of “ablation of thyroid remnants” with I-131 in 511 patients from 1947–1984: experience at University of Michigan. J. Nucl. Med. 25: 1287, 1984.
Goolden A.W.G. The indications for ablating normal thyroid tissue with 131I in differentiated thyroid cancer. Clin. Endocrinol. (Oxf.) 23: 81, 1985.
Mazzaferri E.L. Treating differentiated thyroid carcinoma: where do we draw the line? Mayo Clin. Proc. 66: 105, 1991.
Casara D., Rubello D., Saladini G., Piotto A., Pelizzo M.R., Girelli M.E., Busnardo B. Pregnancy after high therapeutic doses of iodine-131 in differentiated thyroid cancer: potential risks and recommendations. Eur. J. Nucl. Med. 20: 192, 1993.
Balan K.K., Critchley M. Outcome of pregnancy following treatment of well-differentiated thyroid cancer with 131 iodine. Br. J. Obstet. Gynaecol. 99: 1021, 1992.
Edmonds C.J., Smith T. The long-term hazards of the treatment of thyroid cancer with radioiodine. Br. J. Radiol. 59: 45, 1986.
Lin J.D., Chao T.C., Weng H.F., Huang H.S., Ho Y.S. Clinical presentations and results of treatment of 74 occult thyroid carcinoma patients in Northern Taiwan. Am. J. Clin. Oncol. 19: 504, 1996.
Hamburger J.I. Management of hyperthyroidism in children and adolescents. J. Clin. Endocrinol. Metab. 60: 1019, 1985.
Graham G.D., Burman K.D. Radioiodine treatment of Graves’ disease. Ann. Intern. Med. 105: 900, 1986.
Raymond J.P., Izembart M., Marliac V., Dagousset F., Merceron R.E. Temporary ovarian failure in thyroid cancer patients after thyroid remnant ablation with radioactive iodine. J. Clin. Endocrinol. Metab. 69: 186, 1989.
Hodges R.E., Evans T.C., Bradbury J.T., William C.K. The accumulation of radioactive iodine by human fetal thyroid. J. Clin. Endocrinol. Metabol. 15: 661, 1955.
Schlumberger M., De Vathaire F., Ceccarelli C., Delisle M.J., Frances C., Couette J.E., Pinchera A., Parmentier C. Exposure to radioactive iodine-131 for scintigraphy or therapy does not preclude pregnancy in thyroid cancer patients. J. Nucl. Med. 37: 606, 1996.
Ozata M., Suzuki S., Miyamoto T., Liu R.T., Fierro-Renoy F., DeGroot L.J. Serum thyroglobulin in the follow-up of patients with treated differentiated thyroid cancer. J. Clin. Endocrinol. Metab. 79: 98, 1994.
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Lin, JD., Wang, H.S., Weng, H.F. et al. Outcome of pregnancy after radioactive iodine treatment for well differentiated thyroid carcinomas. J Endocrinol Invest 21, 662–667 (1998). https://doi.org/10.1007/BF03350795
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DOI: https://doi.org/10.1007/BF03350795