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Growth factors in the pathogenesis of prolactin-secreting tumors

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References

  1. Kovacs K., Scheithauer B.W., Horvath E., Lloyd R.V. The World Health Organization classification of adenohypophysial neoplasms. A proposed five-tier scheme. Cancer 78: 502, 1996.

    Article  PubMed  CAS  Google Scholar 

  2. Davis J.R.E., Sheppard M.C., Heath D.A. Giant invasive prolactinoma: a case report and review of nine further cases. Q.J. Med. 74: 227, 1990.

    PubMed  CAS  Google Scholar 

  3. Cunnah D., Besser M. Management of prolactinomas. Clin. Endocrinol. (Oxf.) 34: 231, 1991

    Article  CAS  Google Scholar 

  4. Wass J.A.H., Besser G.M. The medical management of hormone-secreting tumors of the pituitary. Annu. Rev. Med. 34: 283, 1983.

    Article  PubMed  CAS  Google Scholar 

  5. De Camilli P., Macconi D., Spada A. Dopamine inhibits adenylate cyclase in human prolactin secreting adenomas. Nature 278: 252, 1979.

    Article  PubMed  Google Scholar 

  6. Wood D.E., Johnston J.M., Johnston D.G. Dopamine, the dopamine D2 receptor and pituitary tumors. Clin. Endocrinol. (Oxf.) 35: 455, 1991.

    Article  CAS  Google Scholar 

  7. Spark R.F., Baker R., Bienfang D.C., Bergland R. Bromocriptine reduces pituitary tumor size and hypersecretion. J. Am. Med. Assoc. 247: 311, 1982.

    Article  CAS  Google Scholar 

  8. Liuzzi A., Dallabonzana D., Oppizzi G., Verde G.G., Cozzi R., Chiodini P., Luccarelli G. Low doses of dopamine agonists in the long-term treatment of macroprolactinomas. N. Engl. J. Med. 313: 656, 1985.

    Article  PubMed  CAS  Google Scholar 

  9. Molitch M.E., Elton R.L., Blackwell R.E., Caldwell B., Chang R.J., Jaffe R., Joplin G., Robbins R.J., Tyson J., Thorner M.O. Bromocriptine as a primary therapy for prolactin-secreting macroadenomas: results of a prospective multicenter study. J. Clin. Endocrinol. Metab. 60: 698, 1985.

    Article  PubMed  CAS  Google Scholar 

  10. Schlechte J.A., Sherman B.M., Chapler F.K., van Gilder J. Long-term follow-up of women with surgically treated prolactin-secreting pituitary tumors. J. Clin. Endocrinol. Metab. 62: 1236, 1986.

    Article  Google Scholar 

  11. Pellegrini I., Rosolonjanahary R., Gunz G., Bertrand P., Delivet S., Jedynak C.P., Kordon C., Peillon F., Jaquet P., Enjalbert A. Resistance to bromocriptine in prolactinomas. J. Clin. Endocrinol. Metab. 69: 500, 1989.

    Article  PubMed  CAS  Google Scholar 

  12. Missale C., Boroni F., Losa M., Giovanelli M., Zanellato A., Dal Toso R., Balsari A., Spano P.F. Nerve growth factor suppresses the transforming phenotype of human prolactinomas. Proc. Natl. Acad. Sci. USA 90: 7961, 1993.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  13. Vallar L., Spada A., Giannattasio G. Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 330: 566, 1987.

    Article  PubMed  CAS  Google Scholar 

  14. Landis C.A., Masters S.B., Spada A., Pace A.M., Bourne H.R., Vallar L. GTPase inhibiting mutations activate the a chain of Gs and stimulate adenylyl cyclase in human pituitary tumors. Nature 340: 692, 1989.

    Article  PubMed  CAS  Google Scholar 

  15. Tordjman K., Stern N., Ouaknine G., Yossiphov Y., Razon N., Nordenskjold M., Friedman E. Activating mutations of the Gs α-gene in nonfunctioning pituitary tumors. J. Clin. Endocrinol. Metab. 77: 765, 1993.

    PubMed  CAS  Google Scholar 

  16. Barbacid M. Ras genes. Annu. Rev. Biochem. 56: 779, 1987.

    Article  PubMed  CAS  Google Scholar 

  17. Bos J.L., Fearon E.R., Hamilton S.R. Prevalence of ras gene mutations in human colorectal cancers. Nature 327: 293, 1987.

    Article  PubMed  CAS  Google Scholar 

  18. Forrester K., Almoguera C., Han K., Grizzle W.E., Perucho M. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298, 1987.

    Article  PubMed  CAS  Google Scholar 

  19. Karga H.J., Alexander J.M., Hedley-Whyte E.T., Klibanski A., Jameson J.L. Ras mutations in human pituitary tumors. J. Clin. Endocrinol. Metab. 74: 914, 1992.

    Article  PubMed  CAS  Google Scholar 

  20. Cai W.Y., Alexander J.M., Hedley-Whyte E.T., Scheithauer B.W., Jameson J.L., Zervas N.T., Klibanski A. Ras mutations in human prolactinomas and pituitary carcinomas. J. Clin. Endocrinol. Metab. 78: 89, 1994.

    PubMed  CAS  Google Scholar 

  21. Alvaro V., Levy L., Dubray C., Roche A., Peillon F., Quérat B., Joubert D. Invasive human pituitary tumors express a point-mutated α-protein kinase-C. J. Clin. Endocrinol. Metab. 77: 1125, 1993.

    PubMed  CAS  Google Scholar 

  22. Levy A., Hall L., Yeudall W.A., Lightman S.L. p53 gene mutations in pituitary adenomas: rare events. Clin. Endocrinol. (Oxf.) 41: 809, 1994.

    Article  CAS  Google Scholar 

  23. Woloschak M., Roberts J.L., Post K.D. Loss of heterozygosity at the retinoblastoma locus in human pituitary tumors. Cancer 74: 693, 1994.

    Article  PubMed  CAS  Google Scholar 

  24. Herman V., Fagin J., Gonsky R., Kovacs K., Melmed S. Clonal origin of pituitary adenomas. J. Clin. Endocrinol. Metab. 71: 1427, 1990.

    Article  PubMed  CAS  Google Scholar 

  25. Herman V., Drazin N.Z., Gonsky R., Melmed S. Molecular screening of pituitary adenomas for gene mutations and rearrangements. J. Clin. Endocrinol. Metab. 77: 50, 1993.

    PubMed  CAS  Google Scholar 

  26. Sporn M.B., Todaro G.J. Autocrine secretion and malignant transformation of cells. N. Engl. J. Med. 308: 878, 1980.

    Article  Google Scholar 

  27. Sporn M.B., Todaro G.J. Autocrine growth factors and cancer. Nature 313: 747, 1985.

    Article  Google Scholar 

  28. Fan X., Childs G.V. Epidermal growth factor and transforming growth factor-α messenger ribonucleic acids and their receptors in the rat anterior pituitary: localization and regulation. Endocrinology 136: 2284, 1995.

    PubMed  CAS  Google Scholar 

  29. Chabot J.G., Walker P., Pelletier G. Distribution of epidermal growth factor binding sites in the adult rat anterior pituitary gland. Peptides 7: 45, 1986.

    Article  PubMed  CAS  Google Scholar 

  30. Childs G.V., Rougeau D., Unabia G. Corticotropin-releasing hormone and epidermal growth factor: mitogens for anterior pituitary corticotropes. Endocrinology 136: 1595, 1995.

    PubMed  CAS  Google Scholar 

  31. Felix R., Meza U., Cota G. Induction of classical lactotropes by epidermal growth factor in rat pituitary cell cultures. Endocrinology 136: 939, 1995.

    PubMed  CAS  Google Scholar 

  32. Missale C., Castelletti L., Boroni F., Memo M., Spano P.F. Epidermal growth factor induces the functional expression of dopamine receptors in the GH3 cell line. Endocrinology 127: 13, 1990.

    Google Scholar 

  33. Altschuler L.R., Parisi M.N., Cageao L.F., Chiocchio S.R., Fernandez-Pol J.A., Zaninovich A.A. Epidermal growth factor stimulates thyrotropin secretion in the rat. Neuroendocrinology 57: 23, 1993.

    Article  PubMed  CAS  Google Scholar 

  34. Childs G.V., Patterson J., Unabia G., Rougeau D., Wu P. Epidermal growth factor enhances ACTH secretion and expression of POMC mRNA by corticotropes in mixed and enriched cultures. Mol. Cell Neurosa. 2: 235, 1991.

    Article  CAS  Google Scholar 

  35. Miyake A., Tasaka K., Otsuka S., Kohmura H., Wakimoto H., Aono T. Epidermal growth factor stimulates secretion of rat pituitary luteinizing hormone-releasing hormone in vitro. Acta Endocrinol. (Copenh.) 108: 175, 1985.

    CAS  Google Scholar 

  36. Polk D.H., Ervin M.G., Padbury J.F., Lam R.W., Reviczky A.L., Fisher D.A. Epidermal growth factor acts as a corticotropin-releasing factor in chronically catheterized fetal lambs. J. Clin. Invest. 79: 984, 1987.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  37. Finley E.L., King J.S., Ramsdell J.S. Human pituitary somatotrophs express transforming growth factor a and its receptor. J. Endocrinol. 141: 547, 1994.

    Article  PubMed  CAS  Google Scholar 

  38. Kobrin M.S., Asa S.L., Samsoondar J., Kudlow J.E. α-Transforming growth factor in the bovine anterior pituitary gland: secretion by dispersed cells and immunohistochemical localization. Endocrinology 121: 1412, 1987.

    Article  PubMed  CAS  Google Scholar 

  39. Samsoondar J., Kobrin M.S., Kudlow J.E. Transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. Purification from conditioned medium. J. Biol. Chem. 261: 14408, 1986.

    PubMed  CAS  Google Scholar 

  40. Driman D.K., Kobrin M.S., Kudlow J.E., Asa S.L. Transforming growth factor-alpha in normal and neoplastic human endocrine tissues. Hum. Pathol. 23: 1360, 1992.

    Article  PubMed  CAS  Google Scholar 

  41. Ren P., Scheithauer B.W., Halper J. Immunohistochemical localization of TGFα, EGF, IGF-I and TGFβ in the normal human pituitary gland. Endocr. Pathol. 5: 40, 1994.

    Article  Google Scholar 

  42. Borgundvaag B., Kudlow J.E., Muller S.G., George S.R. Dopamine receptor activation inhibits estrogen-stimulated transforming growth factor-α gene expression and growth in anterior pituitary, but not in uterus. Endocrinology 130: 3453, 1992.

    PubMed  CAS  Google Scholar 

  43. McAndrew J., Paterson A.J., Asa S.L., McCarthy K.J., Kudlow J.E. Targeting of transforming growth factor-α expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology 136: 4479, 1995.

    PubMed  CAS  Google Scholar 

  44. Burns G., Sarkar D.K. Transforming growth factor-β1-like immunoreactivity in the pituitary gland of the rat: effect of estrogen. Endocrinology 133: 1444, 1993.

    PubMed  CAS  Google Scholar 

  45. Qian X., Jin L., Grande J.P., Lloyd R.V. Transforming growth factor-β and p27 expression in pituitary cells. Endocrinology 137: 3051, 1996.

    PubMed  CAS  Google Scholar 

  46. Sarkar D.K., Kim K.H., Minami S. Transforming growth factor-β1 messenger RNA and protein expression in the pituitary gland: its action on prolactin secretion and lactotropic growth. Mol. Endocrinol. 6: 1825, 1992.

    PubMed  CAS  Google Scholar 

  47. Albaladejo V., Fei Z.L., Nicolas B., Joly-Pharaboz M.O., Avallet O., Vigier M., Andre J. Possible involvement of transforming growth factor β in the inhibition of rat pituitary tumor growth by estradiol. J. Steroid Biochem. Mol. Biol. 41: 125, 1992.

    Article  PubMed  CAS  Google Scholar 

  48. Delidow B.C., Billis W.M., Agarwal P., White B.A. Inhibition of prolactin gene transcription by transforming growth factor β in GH3 cells. Mol. Endocrinol. 5: 1716, 1991.

    Article  PubMed  CAS  Google Scholar 

  49. Pastorcic M., De A., Boyadjieva N., Vale W., Sarkar D.K. Reduction in the expression and action of transforming growth factor β1 on lactotropes during estrogen-induced tumorigenesis in the anterior pituitary. Cancer Res. 55: 4892, 1995.

    PubMed  CAS  Google Scholar 

  50. Finley E.L., Ramsdell J.S. A transforming growth factor a pathway is expressed in GH4C1 rat pituitary tumors and appears necessary for tumor formation. Endocrinology 135: 416, 1994.

    PubMed  CAS  Google Scholar 

  51. Ramsdell J.S. Transforming growth factor α and β are potent and effective inhibitors of GH4 pituitary tumor cell proliferation. Endocrinology 128: 1981, 1991.

    Article  PubMed  CAS  Google Scholar 

  52. Ezzat S., Walpola I.A., Ramyar L., Smyth H.S., Asa S.L. Membrane-anchored expression of transforming growth factor-alpha in human pituitary adenoma cells. J. Clin. Endocrinol. Metab. 80: 534, 1995.

    PubMed  CAS  Google Scholar 

  53. Levi-Montalcini R. The nerve growth factor 35 years later. Science 237: 1154, 1987.

    Article  PubMed  CAS  Google Scholar 

  54. Korsching S. The neurotrophic factor concept: a re-examination. J. Neurosci. 13: 2739, 1993.

    PubMed  CAS  Google Scholar 

  55. Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341: 149, 1989.

    Article  PubMed  CAS  Google Scholar 

  56. Rosenthal A., Goddel D.V., Nguyen T., Lewis M., Shih A., Laramel G.R., Nikolics K., Winslow J.W. Primary structure, biological activity of a novel human neurotrophic factor. Neuron 4: 767, 1990.

    Article  PubMed  CAS  Google Scholar 

  57. Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247: 1446, 1990.

    Article  PubMed  CAS  Google Scholar 

  58. Hohn A., Leibrock J., Bailey K., Barde Y.A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344: 339, 1990.

    Article  PubMed  CAS  Google Scholar 

  59. Ernfors P., Ibanez C.F., Ebendal C.F., Olson L., Persson H. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in brain. Proc. Natl. Acad. Sci. USA 87: 5454, 1990.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  60. Kaplan D.R., Hempstead B.L., Martin-Zanca D., Chao M.V., Parada L.F. The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252: 554, 1991.

    Article  PubMed  CAS  Google Scholar 

  61. Klein R., Jing S., Nanduri V., O’Rourke E., Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65: 189, 1991.

    Article  PubMed  CAS  Google Scholar 

  62. Radeke M.J., Miska P.P., Hsu C., Herzenberg L.A., Shooter E.M. Gene transfer and molecular cloning of the rat nerve growth factor receptor. Nature 325: 593, 1987.

    Article  PubMed  CAS  Google Scholar 

  63. Segal R.A., Greenberg M.E. Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19: 463, 1996.

    Article  PubMed  CAS  Google Scholar 

  64. Bothwell M. Functional interactions of neurotrophins and neurotrophin in receptors. Annu. Rev. Neurosci. 18: 223, 1995.

    Article  PubMed  CAS  Google Scholar 

  65. Bothwell M. p75NTR. A receptor after all. Science 272: 507, 1996.

    Article  Google Scholar 

  66. Carter B.D., Lewin G.R. Neurotrophins live or let die: does p75NTR decide? Neuron 18: 187, 1997.

    Article  PubMed  CAS  Google Scholar 

  67. Carter B.D., Kaltschmidt C., Kaltschmidt B., Offenhauser N., Bohm-Matthaei R., Baeuerle P.A., Barde Y.A. Selective activation of NF-kB by nerve growth factor through the neurotrophin receptor p75. Science 272: 542, 1996.

    Article  PubMed  CAS  Google Scholar 

  68. Dobrowsky R.T., Werher M.M., Castellino A.M., Chao M.V., Hannun Y.A. Activation of the sphingomyelin cycle through the low affinity neurotrophin receptor. Science 265: 1596, 1994.

    Article  PubMed  CAS  Google Scholar 

  69. Levi-Montalcini R., Skaper S.D., Dal Toso R., Petrelli L., Leon A. Nerve growth factor: from neurotrophin to neurokine. Trends Neurosa. 19: 514, 1996.

    Article  CAS  Google Scholar 

  70. Burnham P., Conner J.M., Varon S. Colocalization of NGF and TSH-like immunoreactivity in cultures of adult rat anterior pituitary cells. J. Neurosci. Res. 41: 73, 1995.

    Article  PubMed  CAS  Google Scholar 

  71. Missale C., Boroni F., Sigala S., Buriani A., Fabris M., Leon A., Dal Toso R., Spano P.F. Nerve growth factor in the anterior pituitary: localization in mammotroph cells and cosecretion with prolactin by a dopamine-regulated mechanism. Proc. Natl. Acad. Sci. USA 93: 4240, 1996.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  72. Patterson J.C., Childs G.W. Nerve growth factor and its receptors in the anterior pituitary. Endocrinology 135: 1689, 1994.

    PubMed  CAS  Google Scholar 

  73. Missale C., Boroni F., Frassine M., Caruso A., Spano P.F. Nerve growth factor promotes the differentiation of pituitary mammotroph cells in vitro. Endocrinology 136: 1205, 1995.

    PubMed  CAS  Google Scholar 

  74. Voss J.W., Rosenfeld M.G. Anterior pituitary development: short tales from dwarf mice. Cell 70: 527, 1992.

    Article  PubMed  CAS  Google Scholar 

  75. Porter T.E., Wiles C.D., Frawley L.S. Stimulation of lactotrope differentiation in vitro by fibroblast growth factor. Endocrinology 134: 164, 1994.

    PubMed  CAS  Google Scholar 

  76. Borrelli E., Sawchenko P.E., Evans R.M. Pituitary hyperplasia induced by ectopic expression of nerve growth factor. Proc. Natl. Acad. Sci. USA 89: 2764, 1992.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  77. Missale C., Losa M., Sigala S., Balsari A., Giovanelli M., Spano P.F. Nerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism. Mol. Endocrinol. 10: 272, 1996.

    PubMed  CAS  Google Scholar 

  78. Missale C., Losa M., Boroni F., Giovanelli M., Balsari A., Spano P.F. Nerve growth factor and bromocriptine: a sequential therapy for human bromocriptine-resistant prolactinomas. Br. J. Cancer 72: 1397, 1995.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  79. Ben-Jonathan N. Dopamine: a prolactin-inhibiting hormone. Endocrine Rev. 6: 564, 1985.

    Article  CAS  Google Scholar 

  80. Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron 19: 127, 1997.

    Article  PubMed  CAS  Google Scholar 

  81. Saiardi A., Bozzi Y., Baik J.H., Borrelli E. Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. Neuron 19: 115, 1997.

    Article  PubMed  CAS  Google Scholar 

  82. Kelly M.A., Rubinstein M., Asa S.L., Zhang G., Saez C., Bunzow J.R., Allen R.G., Hnasko R., Ben-Jonathan N., Grandy D.K., Low M.J. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 19: 103, 1997.

    Article  PubMed  CAS  Google Scholar 

  83. Sarkar D.K., Gottschall P.E., Meites J. Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors. Science 218: 684, 1982.

    Article  PubMed  CAS  Google Scholar 

  84. Amara S.G., Kuhar M.J. Neurotransmitters transporter: recent progress. Annu. Rev. Neurosci. 16: 73, 1993.

    Article  PubMed  CAS  Google Scholar 

  85. Giros B., Caron M.G. Molecular characterization of the dopamine transporter. Trends Pharmacol. Sci. 14: 43, 1993.

    Article  PubMed  CAS  Google Scholar 

  86. Giros B., Jaber M., Jones S.R., Wightmann R.M., Caron M.G. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379: 606, 1996.

    Article  PubMed  CAS  Google Scholar 

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  1. Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Via Valsabbina 19, 25124, Brescia, Italy

    Cristina Missale & P. F. Spano

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Missale, C., Spano, P.F. Growth factors in the pathogenesis of prolactin-secreting tumors. J Endocrinol Invest 21, 402–411 (1998). https://doi.org/10.1007/BF03350778

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