Abstract
Plasma arginine vasopressin (AVP) was measured in 24 patients with polyuria exceeding 3.5 l/day diagnosed as severe or partial diabetes insipidus according to the dehydration test. All patients with severe diabetes insipidus diagnosed by the dehydration test had very low or undetectable basal AVP values and always subnormal plasma osmolality. Patients with partial diabetes insipidus diagnosed by the dehydration test had a wide range of AVP and osmolality values. The stimulation test performed on these patients was able to differentiate patients with primary polydipsia from patients with partial diabetes insipidus. The measurement of basal plasma AVP is capable of diagnosing all patients with severe diabetes insipidus; when we combine the stimulation test with the measurement of AVP, we can differentiate partial diabetes insipidus from other forms of polyuria.
Similar content being viewed by others
References
Dashe A.M., Cramm R.E., Crist C.A., Habener J.F., Solomon D.H. A water deprivation test for the differential diagnosis of polyuria. JAMA 185: 699, 1963.
Price J.D.E., Lauener R.W. Serum and urine osmolalities in the differential diagnosis of polyuria states. J. Clin. Endocrinol. Metab. 26: 143, 1966.
Edelman C.M., Barnett H.L, Stark H., Boichis H., Soriano J.R. A standardized test of renal concentrating capacity in children. Am. J. Dis. Child. 114: 639, 1967.
Moses A.M., Streeten D.H.P. Differentiation of polyuria states by measurement of responses to changes in plasma osmolality induced by hypertonic saline infusions. Am. J. Med. 42: 368, 1967.
Miller M., Dalakos T., Moses A.M., Fellerman H., Streeten D.H.P. Recognition of partial defects in antidiuretic hormone secretion. Ann. Intern. Med. 73: 721, 1970.
Zerbe R.L, Robertson M.D. A comparison of plasma vasopressin measurement with a standard indirect test in the differential diagnosis of polyuria. N.Engl. J.Med. 305: 1539, 1981.
Robertson G.L, Mahr F.A., Athar S., Sinha T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J.Clin. Invest. 52: 2340, 1973.
Baylis P.H., Heath D.A. The development of radioimmunoassay for the measurement of human plasma arginine vasopressin. Clin. Endocrinol. (Oxf). 7: 91, 1977.
Thibonier M., Soto M.E., Marchetti J., Corvol P., Menard J., Millez P. Dosage radioimmunologique de la Vasopressine plasmatique. Ann. Endocrinol. (Paris) 41: 379, 1980.
Rooke P., Baylis P.H. A new sensitive radioimmunoassay for plasma arginine vasopressin. J. Immunol. 3: 115, 1982.
Baylis P.H., Robertson G.L. Plasma vasopressin response to hypertonic saline infusion to assess posterior pituitary function. J. Roy. Soc. Med. 73: 255, 1980.
Baylis P.H., Gasklill M.B., Robertson G.L. Vasopressin secretion in primary polydipsia and cranial diabetes insipidus. Quart. J. Med. N.S. 50: 345, 1981.
Greenwood F.C., Hunter W.H., Glover J.C. The preparation of 131 I-labelled human growth hormone of high specific radioactivity. Biochem. J. 89: 114, 1963.
Desbuquois A., Aurbach G.D. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassay. J. Clin. Endocrinol. Metab. 33: 732, 1971.
La Rochelle F.T., North W.G., Stern P. A new extraction of arginine vasopressin from blood: the use of octadecasilylsilica. Pfluegers. Arch. 387: 79, 1980.
Czernichow P., Pomarède R., Basmaciogullari A., Rappaport R. Diabetes insipidus in children. Arginine-vasopressin determination in plasma during short dehydration test. Acta Paediatr. Scand. (Suppl.) 277: 64, 1979.
Camps J., Perez-Ayuso R.M., Martinez-Vea A. Exploracion funcional de la hormona antidiurética. Méd. Clin. (Barcelona) 80: 85, 1983.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sanmartí, A., Galard, R., Catalàn, R. et al. Plasmatic arginine vasopressin levels in total and partial diabetes insipidus. J Endocrinol Invest 8, 127–130 (1985). https://doi.org/10.1007/BF03350666
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03350666