Abstract
The presence of estradiol (E) and progesterone (Pg) receptors (R) has been demonstrated also in normal and neoplastic tissues known to be hormone-independent and in particular in primitive colonic cancer, and, possibly, in healthy colonic mucosa. In this study endoscopic and surgical colonic mucosa specimens from 55 subjects were analyzed and divided as follows: 21 samples from healthy subjects, 12 normal mucosa samples from subjects affected with colonic cancer, 8 adenomatous polyps specimens, 5 samples from ulcerative colitis drawn on areas showing macroscopic lesions and 9 colonic cancer specimens. In the control group we have observed 6 cases positive for ER (28.6%) and 2 positive for PgR (14, 3%). Six normal mucosa specimens from subjects affected with colonic cancer were found to be positive for ER (50%) and 2 for PgR (16.7%). Five colonic cancers resulted ER positive (55.5%) and 4 PgR positive (44.4%). Four polyps were ER positive (50%) and 3 PgR positive (37.5%); in this group only one subject showed positive binding in the surrounding normal tissue. These data confirm the presence of ER and PgR in colonic cancer and colonic adenomas (so-called precancerous disease); in these subjects the finding of steroid receptors also in normal mucosa suggests that the presence of steroid binding could be considered as a marker of a precancerous condition.
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Jensen E.V., De Sombre E.R., Jungblut P.W. Estrogen receptors in hormone- responsive tissues and tumors. In: Wissler R.W., Dao T.L, Wood S. jr. (Eds.), Endogenous factors influencing host-tumor balance. University of Chicago, Press, Chicago, 1967, p. 15.
Lippman M.E. Steroid receptor analysis and endocrine therapy of breast cancer. In: Bresciani F. (Ed.), Perspectives in steroid receptor research. Raven Press, New York, 1980, p. 217.
Mc Guire W.L. Estrogen receptors in human breast cancer. J.Clin. Invest. 52: 73, 1973.
Pollow K., Lübbert H., Boquoi E., Krenzer G., Pollow B. Characterization and comparison of receptor for 17β-estradiol and progesterone in human proliferative endometrium and endometrial carcinoma. Endocrinology 96: 319, 1975.
Galli M.C., De Giovanni C., Nicoletti G., Grilli S., Nanni P., Prodi G., Gola G., Rocchetta R., Orlandi C. The occurrence of multiple steroid hormone receptors in disease-free and neoplastic human ovary. Cancer 47: 1297, 1981.
Golomb H.M., Thomsen S. Estrogen receptor. Therapeutic guide in undifferentiated metastatic carcinoma in woman. Arch. Intern. Med. 135: 942, 1975.
Hsu R.S. Androgen receptors in human prostate. In: Charles CT., (Ed.), Normal and abnormal growth of the prostate. Springfield, 1975, p. 633.
Lippman M.E., Halterman R.H., Leventhal V.G., Perry S., Thompson E.B. Glucocorticoid binding proteins in human acute lymphoblastic leukemia blast cells. J. Clin. Invest. 52: 1715, 1973.
Fisher R.I., Neifield M.E., Lippman M.E. Estrogen receptor in human malignant melanoma. Lancet 2: 337, 1976.
Concolino G., Marocchi A., Conti S., Liberti M., Tenaglia R., Di Silverio F. Endocrine treatment and steroid receptors in urological malignancies. In: Lacobelli S., King R.J.B., Lindner H.R., Lippman E.M., (Eds.), Hormones and cancer. Raven Press, New York, 1980, p. 403.
Donnell M.S., Meyer G.A., Donegan W.L Estrogen-receptor protein in intracranial meningiomas. J. Neurosurg. 50: 499, 1979.
Yu Z.Y., Wrange O., Haglund V., Granholm L., Gustafsson J.A. Estrogen and progestin receptors in intracranial meningiomas. J. Steroid Biochem. 16: 451, 1982.
Baulieu E., Atgar M., Best-Belpomme M., Corvol P., Courvalin J.C., Mester J., Milgrom E., Robel P., Rockefort H., de Catalogne D. Steroid hormone receptors. Vitam. Horm. 33: 649, 1975.
Sandberg A.A., Kirdani R.Y., Vardaralis M.J., Murphy G.A. Estrogen receptor protein of pancreas. Steroids 22: 259, 1973.
Herman J.B. Breast cancer and associated extramammary malignant neoplasm. Am. J. Surg. 124: 620, 1972.
Howell M.A. The association between colorectal cancer and breast cancer. J. Chron. Dis. 29: 243, 1976.
Berg J.W. Can nutrition explain the pattern of international epidemiology of hormone-dependent cancer? Cancer Res. 35: 3345, 1975.
Hill M.F., Goddard P., Williams R.E.O. Gut bacteria and the etiology of cancer of the breast. Lancet 2: 472, 1972.
Alford T.C., Do H.M., Geelhoed G.W., Tsangaris N.T., Lippman M.E. Steroid hormone receptors in human colon cancers. Cancer 43: 980, 1979.
McClendon J.E., Appleby D., Clandon D.B., Donegan W.L, De Cosse J.J. Colon neoplasm, tissue estrogen receptor and carcino-embryonic antigen. Arch. Surg. 112: 240, 1977.
Sica V., Contieri E., Nola E., Bova R., Papaleo G., Puca G.A. Estrogen and progesterone binding proteins in human colorectal cancer. A preliminary characterization of estradiol receptor. Tumori 67: 307, 1981.
Concolino G., Marocchi A., Vecchio F.M. Picardi S Steroid receptors in human colo-rectal tract. J. Steroid Biochem. 19 (Suppl.): 127s, 1983 (Abstract).
Lowry O.H., Rosebrough N.J., Farr A.L, Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265, 1951.
King R.J.B. Analysis of estradiol and progesterone receptors in early and advanced breast tumors. Cancer 46: 2818, 1980.
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Marugo, M., Molinari, F., Fazzuoli, L. et al. Estradiol and progesterone receptors in normal and pathologic colonic mucosa in humans. J Endocrinol Invest 8, 117–119 (1985). https://doi.org/10.1007/BF03350662
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DOI: https://doi.org/10.1007/BF03350662