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Effect of 1, 25-dihydroxyvitamin D3 and nifedipine on prolactin release in normal man

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Abstract

In normal man 1, 25 (OH)2-vitamin D3 [1, 25 (OH)2D] increases both basal and TRH-stimulated prolactinemia; this effect is completely reversible by the calcium antagonist nifedipine. Similarly the 1, 25 (OH)2D-induced hypercalcemia is totally inhibited by nifedipine. These findings suggest that both biological effects of 1, 25 (OH)2D are mediated by calcium-dependent mechanisms.

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Authors and Affiliations

  1. Department of Medicine and Radioimmunoassay Laboratory, Academisch Ziekenhuis (VUB), 1090, Brussels, Belgium

    D. Verbeelen, L. Vanhaelst & A. C. Van Steirteghem

  2. Department of Medicine, Hôpital Brugmann (ULB), 1020, Brussels, Belgium

    M. Fuss

Authors
  1. D. Verbeelen
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  2. L. Vanhaelst
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  3. M. Fuss
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  4. A. C. Van Steirteghem
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Verbeelen, D., Vanhaelst, L., Fuss, M. et al. Effect of 1, 25-dihydroxyvitamin D3 and nifedipine on prolactin release in normal man. J Endocrinol Invest 8, 103–106 (1985). https://doi.org/10.1007/BF03350657

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  • DOI: https://doi.org/10.1007/BF03350657

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