Skip to main content
SpringerLink
Log in

Ketanserin without effects on basal anterior pituitary hormone secretion in healthy subjects

  • Short Communication
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

The effect of ketanserin, a selective serotonin-2 (5-HT2) receptor blocking agent, on the secretion of anterior pituitary hormones was studied in 4 healthy volunteers. Ketanserin (10 mg) was administered as a slow iv injection and its effect was compared with that of saline. Ketanserin influenced neither the basal plasma levels of HGH, ACTH, TSH, LH or prolactin, nor the plasma levels of T4, T3, Cortisol or glucose. Even if a single dose of ketanserin had no hormonal effects, this must also be studied after long term use.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Jacoby J.H., Thomas R.F. Neuroendocrine consequences of chemical indolectomy. Ann. NY Acad. Sci. 305: 387, 1978.

    Article  PubMed  CAS  Google Scholar 

  2. Krulich L. Central neurotransmitters and the secretion of prolactin, GH, LH and TSH. Ann. Rev. Physiol. 41: 603, 1979.

    Article  CAS  Google Scholar 

  3. Vale W., Rivier C., Brown M. Regulatory peptides of the hypothalamus. Ann. Rev. Physiol. 39: 473, 1977

    Article  CAS  Google Scholar 

  4. Tuomisto J. Neuropharmacological intervention on the pituitary-hy-pothalamic relationship. Annu. Clin. Res. 10:120, 1978.

    CAS  Google Scholar 

  5. Kordon C., Enjalbert A., Hery M., Joseph-Bravo P.I., Rotsztejn W., Ruberg M. Role of neurotransmitters in the control of adenohy-pophyseal secretion. In: Morgane P.J., Panksepp J. (Eds.), Handbook of the hypothalamus. Marcel Dekker, Inc., New York, 1980, vol. 2, p. 253.

    CAS  Google Scholar 

  6. Meltzer H.Y., Simonovic M., Gudelsky G.A. Effects of pirenperone and ketanserin on rat prolactin secretion in vivo and in vitro. Eur. J. Pharmacol. 92: 83, 1983.

    Article  PubMed  CAS  Google Scholar 

  7. Rocco A., De Giorgio G., Buongiomo T., Proietti A., Lucchetti G., Falaschi P. Prolactin response to R 41468, a new specific 5HT-2 antagonist. Neuroendocrinol. Lett. 5: 47, 1983.

    CAS  Google Scholar 

  8. Rocco A., Melis G.B., Proietti A., Fruzzetti F., Buongiomo T., Paoletti A.M., Kemeni A., Lucchetti G., Falaschi P. Elect of ketanserin, a specific’5-HT-2 receptor antagonist, on prolactin secretion. J. Endocrinol. Invest. 6 (Suppl. 1): 40, 1983.

  9. Leysen J.E., Awouters F., Kennis L., Laduron P.M., Vandenberk J., Janssen P.A.J. Receptor binding profile of R 41468, a novel antagonist at 5-HT2 receptors. Life Sci. 28:1015, 1981.

    Article  PubMed  CAS  Google Scholar 

  10. Laduron P.M., Janssen P.F.M., Leysen J.E. In vivo binding of (3H) ketanserin on serotonin S2-receptors in rat brain. Eur. J. Pharmacol. 81: 43, 1982.

    Article  PubMed  CAS  Google Scholar 

  11. Peroutka S.J., Snyder S.H. Multiple serotonin receptors: differential binding of (3H) 5-hydroxytryptamine, (3H) lysergic acid diethylamide and (3H) spiroperidol. Mol. Pharmacol. 16: 687, 1979.

    PubMed  CAS  Google Scholar 

  12. Peroutka S.J., Lebovitz R.M., Snyder S.H. Two distinct central serotonin receptors with different physiological functions. Science 212: 827, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Van Neuten J.M., Janssen P.A.J., Van Beek J., Xhonneux R., Verbeuren T.J., Vanhoutte M.P. Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. J. Pharmacol. Exp. Ther. 218: 217, 1981.

    Google Scholar 

  14. Kalkman H.O., Timmermans P.B.M.W.M., van Zwieten P.A. Characterization of the antihypertensive properties of ketanserin (R 41 458) in rats. J. Pharmacol. Exp. Ther. 222: 227, 1982.

    PubMed  CAS  Google Scholar 

  15. De Cree J., Verhaegen H., Symoens J. Acute blood-pressure-lowering effect of ketanserin. Lancet 7:1161, 1981.

    Google Scholar 

  16. De Cree J., Leempoels J., De Cock W., Geukens H., Verhaegen H. The antihypertensive effect of a pure and selective serotonin-receptor blocking agent (R 41 468) in elderly patients. Angiology 32:137, 1981.

    Article  PubMed  Google Scholar 

  17. De Cree J., Leempoels J., Geukens H., De Cock W., Verhaegen H. The antihypertensive effects of ketanserin (R 41468) a novel 5-hydroxytryptamine-blocking agent, in patients with essential hypertension. Clin. Sci. Mol. Med. 67:473, 1981.

    Google Scholar 

  18. Wenting G., Man in ’t Veld A.J., Woittiez A.J., Boomsa F., Schalenkamp M.A.D.H. Treatment of hypertension with ketanserin, a new selective 5-HT2 receptor antagonist. Br. Med. J. 284: 537, 1982.

    Article  CAS  Google Scholar 

  19. Mattila J. Central regulation of rat thyrotropin secretion by monoamines, GABA and the pineal gland. Dissertation. Helsinki, 1981.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Endocrine Laboratory and Minerva Foundation for Medical Research, University of Helsinki, Helsinki, P.O. Box 819, SF 00101, Helsinki 10, Finland

    A. Gordin M.D.

  2. Third Department of Medicine, University of Helsinki, Helsinki, SF 00101, Helsinki 10, Finland

    P. Mustajoki & R. Pelkonen

Authors
  1. A. Gordin M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Mustajoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Pelkonen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gordin, A., Mustajoki, P. & Pelkonen, R. Ketanserin without effects on basal anterior pituitary hormone secretion in healthy subjects. J Endocrinol Invest 8, 73–75 (1985). https://doi.org/10.1007/BF03350647

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03350647

Key-words

Search

Navigation