Skip to main content
SpringerLink
Log in

Pituitary and gonadal function in the infant son of a patient with hypogonadofropic hypogonadism

  • Case Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

We have evaluated the pituitary-gonadal function of the infant son of a patient with hypogonadotropic hypogonadism. The father was treated with hCG and FSH to induce fertility. The son had normal external genitalia and his testicular volume increased appropriately during early infancy. Basal and post GnRH gonadotropin levels, as well as testosterone concentrations increased during early infancy. The data suggest that this infant had adequate gonadotropin secretion and testicular function. The patient illustrates the potential usefulness of evaluating the pituitary-gonadal function of male infants suspected of having hypogonadotropic hypogonadism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kallmann F., Schonfeld W.A., Barrera SE Genetic aspects of primary eunuchoidism. Am. J. Ment. Defic. 48: 203, 1944.

    Google Scholar 

  2. De Morsier G. Etudes sur les dysraphies cranioencephaliques. Schweiz. Arch. Neurol. Neurochir. Psychiatr. 74: 309, 1954.

    Google Scholar 

  3. Sparkes R.S., Simpson R.W., Paulsen C.A. Familial hypogonadotropic hypogonadism with anosmia. Arch. Intern. Med. 121: 534, 1968.

    Article  PubMed  CAS  Google Scholar 

  4. Schroffner W.G., Furth E.D. Hypogonadotropic hypogonadism with anosmia (Kallmann’s syndrome) unresponsive to clomiphene citrate. J. Clin. Endocrinol. Metab. 31: 267, 1970.

    Article  PubMed  CAS  Google Scholar 

  5. Santen R.J., Paulsen C.A. Hypogonadotropic eunuchoidism. I. Clinical study of the mode of inheritance. J. Clin. Endocrinol. Metab. 36: 47, 1973.

    Article  PubMed  CAS  Google Scholar 

  6. Forest M.G., Sizonenko P.C., Cathiard A.M. Hypophysogonadal function in humans during the first year of life. J.Clin. Invest. 53: 819, 1974.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  7. Delitala G., Meloni T., Masala A. Effect of LRH on gonadotropin secretion in newborn male infants. J. Clin. Endocrinol. Metab. 46: 689, 1978.

    Article  PubMed  CAS  Google Scholar 

  8. Evan-Brion D., Gendrel D., Bozzola M. Diagnosis of Kallmann’s syndrome in early infancy. Acta Paediatr. Scand. 71: 937, 1982.

    Article  Google Scholar 

  9. Cassorla F.G., Golden S.M., Johnsonbaugh R.E. Testicular volume during early infancy. J. Pediatr. 99: 742, 1981.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10B09, NIH, Bethesda, MD, 20205, USA

    F. G. Cassorla M.D., O. Pescovitz, D. L. Loriaux & R. J. Sherins

Authors
  1. F. G. Cassorla M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Pescovitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. L. Loriaux
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. J. Sherins
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cassorla, F.G., Pescovitz, O., Loriaux, D.L. et al. Pituitary and gonadal function in the infant son of a patient with hypogonadofropic hypogonadism. J Endocrinol Invest 8, 71–72 (1985). https://doi.org/10.1007/BF03350646

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03350646

Key-words

Search

Navigation