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Progress in neuroendocrinology: LH releasing (LHRH), basic and clinical aspects

  • Memorial Lecture in Honor of Prof. A. Lunedei
  • Published:
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References

  1. Lunedei A. Patologia del sistema nervoso vegetativo e degli organi endocrini. In; Ceconi A., Micheli F. (Eds.), Internal medicine. Edizioni Minerva Medica, Torino, 1932, vol. 6, p. 163.

    Google Scholar 

  2. McCann S.M., Taleisnik S., Friedman H.M. LH-releasing activity in hypothalamic extracts. Proc. Soc. Exp. Biol. Med. 104: 432, 1960.

    Article  CAS  Google Scholar 

  3. Campbell H.J., Feuer G., Harris G.W. The effect of intrapituitary infusion of median eminence and other brain extracts on anterior pituitary gonadotropin secretion. J. Physiol. (London) 170: 474, 1964.

    CAS  Google Scholar 

  4. Matsuo H., Baba Y., Nair R.M., Arimura A., Schally A.V. Structure of the porcine LH-and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem. Biophys. Res. Commun. 43: 134, 1971.

    Article  Google Scholar 

  5. Barry J., DuBois M.P., Carette B. Immunofluorescence study of the preoptico-infundibular LRF neurosecretory pathway in the normal, castrated or testosterone-treated male guinea pig. Endocrinology 95: 1416, 1974.

    Article  PubMed  CAS  Google Scholar 

  6. Samson W.K., McCann S.M., Chud L., Dudley C.A., Moss R.L. Intra and extrahypothalamic luteinizing hormone releasing hormone distribution in the rat with special reference to mesencephalic sites which contain both LHRH and single neurons responsive to LHRH. Neuroendocrinology 31: 66, 1980.

    Article  PubMed  CAS  Google Scholar 

  7. Phillips H.S., Hostetter G., Kerdelhue B., Kozlowski G.B. Immunocytochemical localization of LHRH in central olfactory pathways of hamster. Brain Res. 193: 574, 1980.

    Article  PubMed  CAS  Google Scholar 

  8. Sharpe R.N. Extra pituitary actions of LHRH and its antagonists. Nature 286: 12, 1980.

    Article  PubMed  CAS  Google Scholar 

  9. Turkelson C.M., Arimura A., Pauli W., Fishback J. LHRH agonists binders and LHRH-like substance in rat testis. 63rd Ann. Meeting Endocrine Sac. p. 99, 1981 (Abstract).

    Google Scholar 

  10. Ying S.Y., Ling N., Bohlen B., Guillemin R. Gonadocrinins: Peptides in ovarian follicular fluid stimulating the secretion of pituitary gonadotropin. Endocrinology 108: 1206, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Khodr G.S., Siler-Khodr T.M. Placental luteinizing hormone releasing factor and its synthesis. Science 207: 315, 1980.

    Article  PubMed  CAS  Google Scholar 

  12. Koch Y., Baram T. Gonadotropin releasing hormone in milk. Science 198: 300, 1977.

    Article  PubMed  Google Scholar 

  13. McCann S.M. Regulation of secretion of follicle-stimulating hormone and luteinizing hormone. In: Greep R.O., Astwood E.B. (Eds.), Handbook of physiology. Williams and Wilkins, Baltimore, 1974, vol. 4, p. 489.

    Google Scholar 

  14. Ojeda S.R., Andrews W.W., Advis J.P., Smith White S. Recent advances in the endocrinology of puberty. Endocrine Rev. 1: 228, 1980.

    Article  CAS  Google Scholar 

  15. Knobil E. Neuroendocrine control of the menstrual cycle. Recent Prog. Horm. Res. 36: 53, 1980.

    PubMed  CAS  Google Scholar 

  16. Ajika K., Kalra S.P., Fawcett C.P., Krulich L., McCann S.M. The effect of stress and nembutal on plasma levels of gonadotropins and prolactin in ovariectomized rats. Endocrinology 90: 707, 1972.

    Article  PubMed  CAS  Google Scholar 

  17. Libertun C., Orias R., McCann S.M. Biphasic effect of estrogen on the sensitivity of the pituitary to luteinizing hormone-releasing factor. Endocrinology 94: 1094, 1974.

    Article  PubMed  CAS  Google Scholar 

  18. Fink G. Feedback actions of target hormones on hypothalamus and pituitary with special reference to gonadal steroids. Ann. Rev. Physiol. 41: 571, 1979.

    Article  CAS  Google Scholar 

  19. Goodman R.L. A quantitative analysis of the physiological role of estradiol and progesterone in the control of tonic and surge secretion of luteinizing hormone in the rat. Endocrinology 102: 142, 1978.

    Article  PubMed  CAS  Google Scholar 

  20. Yen S.S.C. Neuroendocrine aspects of the regulation of cyclic gonadotropin release in women. In: Hubinot P.O., L’Hermite M., Robin C. (Eds.), Clinical reproductive neuroendocrinology. Karger, Basel, 1977, p. 150.

    Google Scholar 

  21. Libertun C., McCann S.M. Pituitary sensitization to LH-releasing hormone (LHRH) by progesterone. Fed. Proc. 33: 212, 1974.

    Google Scholar 

  22. Zeballos G., McCann S.M. Alterations during the estrous cycle in the responsiveness of the pituitary to subcutaneous administration of synthetic LH-releasing hormone (LHRH). Endocrinology 96: 1377, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Castro-Vazquez A., McCann S.M. Cyclic variations in the increased responsiveness of the pituitary to luteinizing hormone-releasing hormone (LHRH) induced by LHRH. Endocrinology 97: 13, 1975.

    Article  PubMed  CAS  Google Scholar 

  24. Aiyer M.S., Chiappa S.A., Fink G. A priming effect of luteinizing hormone releasing factor on the anterior pituitary gland in the female rat. J. Endocrinol. 62: 573, 1974.

    Article  PubMed  CAS  Google Scholar 

  25. Neill J.D. LHRH and dopamine secretion into hypophyseal stalk blood — effects of estrogens, mating and nursing. Front. Horm. Res. 6: 192, 1980.

    CAS  Google Scholar 

  26. Wildt L., Hausler A., Hutchinson J.S., Marshall G., Knobil E. Estradiol as a gonadotropin releasing hormone in the Rhesus monkey. Endocrinology 108: 2011, 1981.

    Article  PubMed  CAS  Google Scholar 

  27. Pavasuthitaisit K., Hess D.L., Norman R.L., Adams T.E., Baughman W.L., Spies H.G. Dopamine effects on prolactin and luteinizing hormone secretion in ovariectomized Rhesus macaques after transection of the pituitary stalk. Neuroendocrinology 32: 42, 1981.

    Article  Google Scholar 

  28. Marshall J.C., Bourne G.A., Frager M.S., Pieper D.R. Pituitary gonadotropin-releasing hormone receptors-physiological changes and control of receptor number. In: Mahesh V.B., Muldoon T.G., Saxena B.B., Sadler W.A. (Eds.), Functional correlates of hormone receptors in reproduction. Elsevier-North-Holland, New York, 1981, p. 93.

    Google Scholar 

  29. Labrie F., Borgeat P., Drouin J., Beaulieu M., Lagacé L., Ferland L., Raymond V. Mechanism of action of hypothalamic hormones in the adenohypophysis. Ann. Rev. Physiol. 41: 555, 1979.

    Article  CAS  Google Scholar 

  30. Naor Z., Snyder G., Fawcett C.P., McCann S.M. A possible role for cyclic GMP in mediating the effect of luteinizing hormone releasing hormone on gonadotropin release in dispersed pituitary cells of the female rat. J. Cyclic Nucleotide Res. 4: 475, 1978.

    PubMed  CAS  Google Scholar 

  31. Snyder G., Naor Z., Fawcett C.P., McCann S.M. Gonadotropin release and cyclic nucleotides: evidence for LHRH-induced elevation of cyclic GMP levels in gonadotrophs. Endocrinology 107: 1627, 1980.

    Article  PubMed  CAS  Google Scholar 

  32. Naor Z., Catt K.J. Independent actions of gonadotropin releasing hormone upon cyclic GMP production and LH release. J. Biochem. 225: 342, 1980.

    Google Scholar 

  33. McCann S.M. Mechanism of action of hypothalamic hypophyseal stimulating and inhibiting hormones. In: Ganong W.F., Martini L. (Eds.), Frontiers in neuroendocrinology. Oxford University Press, New York, 1971, p. 209.

    Google Scholar 

  34. McCann S.M., Krulich L., Ojeda S.R., Negro-Vilar A., Vijayan E. Neurotransmitters in control of anterior pituitary function. In: Fuxe K., Hökfelt T., Luft R. (Eds.), Central regulation of the endocrine system. Plenum Press, New York, 1979, p. 329.

    Chapter  Google Scholar 

  35. Weiner R.I, Ganong W.F. Role of brain monoamines and histamine in regulation of anterior pituitary secretion. Physiol. Rev. 58: 905, 1978.

    PubMed  CAS  Google Scholar 

  36. Barraclough C.A., Sawyer C.H. Inhibition of the release of pituitary ovulatory hormone in the rat by morphine. Endocrinology 57: 329, 1955.

    Article  PubMed  CAS  Google Scholar 

  37. Cirero T.J., Badger T.M., Wilcox C.E., Bell R.D., Myer E.R. Morphine decreases luteinizing hormone by an action of the hypothalamic pituitary axis. J. Pharmacol. Exp. Ther. 203: 548, 1977.

    Google Scholar 

  38. Sylvester P.W., Chen H.T., Meites J. Effects of morphine and naloxone on phasic release of LH and FSH. Proc. Soc. Exp. Biol. Med. 164: 207, 1980.

    Article  PubMed  CAS  Google Scholar 

  39. Hery M, Laplant E., Kordon C. Participation of serotonin in phasic release of LH. I. Evidence from pharmacological experiments. Endocrinology 99: 496, 1976.

    Article  PubMed  CAS  Google Scholar 

  40. Weick R.F. Acute effects of adrenergic receptor blocking drugs and neuroleptic agents on pulsatile discharges of luteinizing hormone in the ovariectomized rat. Neuroendocrinology 26: 108, 1978.

    Article  PubMed  CAS  Google Scholar 

  41. Vijayan E., McCann S.M. Re-evaluation of the role of catecholamines in control of gonadotropin and prolactin release. Neuroendocrinology 25: 150, 1978.

    Article  PubMed  CAS  Google Scholar 

  42. Negro-Vilar A., Ojeda S.R., McCann S.M. Catecholaminergic modulation of luteinizing hormone-releasing hormone release by median eminence terminals in vitro. Endocrinology 104: 1749, 1979.

    Article  PubMed  CAS  Google Scholar 

  43. Gnodde H.P., Schuiling G.A. Involvement of catecholaminergic and cholinergic mechanisms in the pulsatile release of LH in the longterm ovariectomized rat. Neuroendocrinology 20: 212, 1976.

    Article  PubMed  CAS  Google Scholar 

  44. Vijayan E., McCann S.M. The effects of systemic administration of dopamine and apomorphine on plasma LH and prolactin concentrations in conscious rats. Neuroendocrinology 25: 221, 1978.

    Article  PubMed  CAS  Google Scholar 

  45. Gallo R.V. Neuroendocrine regulation of pulsatile luteinizing hormone release in the rat. (Review) Neuroendocrinology 30: 122, 1980.

    Article  PubMed  CAS  Google Scholar 

  46. Ojeda S.R., Negro-Vilar A., McCann S.M. Effect of catecholaminergic transmission blockade on prostaglandin E (PGE) release by the median eminence (ME) and modulatory effect of ovarian steroids on PGE-induced LHRH release in vitro. 61st Ann. Meeting Endocrine Soc. 446: 184,1979 (Abstract).

    Google Scholar 

  47. Fiorindo R., Justo G., Motta M., Simonovic I., Martini L. Acetylcholine and secretion of pituitary gonadotropins. In: Motta M, Crosignani P., Martini L. (Eds.), Hypothalamic hormones. Academic Press, New York, 1974, p. 195.

    Google Scholar 

  48. Vijayan E., McCann S.M. Effect of blockade of dopaminergic receptors on acetylcholine (Ach)-induced alterations of plasma gonadotropin and prolactin (Prl) in conscious ovariectomized rats. Brain Res. Bull. 5: 23, 1980.

    Article  PubMed  CAS  Google Scholar 

  49. Negro-Vilar A., Advis J.P., Ojeda S.R., McCann S.M. Pulsatile LH patterns in ovariectomized rats: Involvement of norepinephrine and dopamine in the release of LHRH and LH. Endocrinology (1981, submitted).

    Google Scholar 

  50. Soper B.D., Weick R.F. Hypothalamic and extrahypothalamic mediation of pulsatile discharges of luteinizing hormone in the ovariectomized rat. Endocrinology 106: 348, 1980.

    Article  PubMed  CAS  Google Scholar 

  51. Sarkar D.K., Fink G. Gonadotropin-releasing hormone surge-possible modulation through postsynaptic alpha-adrenoreceptors and two pharmacologically distinct dopamine receptors. Endocrinology 108: 862, 1981.

    Article  PubMed  CAS  Google Scholar 

  52. Meites J, Bruni J.F, Van Vugt D.A, Smith A.F. Relation of endogenous peptides in morphine to neuroendocrine function. Life Sci. 24: 1325, 1979.

    Article  PubMed  CAS  Google Scholar 

  53. Schneider H.P.G., McCann S.M. Mono- and indolamines and control of LH-secretion. Endocrinology 86: 1127, 1970.

    Article  PubMed  CAS  Google Scholar 

  54. Libertun C., McCann S.M. The possible role of histamine in the control of prolactin and gonadotropin release. Neuroendocrinology 20: 110, 1976.

    Article  PubMed  CAS  Google Scholar 

  55. McCann S.M., Vijayan E., Negro-Vilar A. Role of gamma aminobutyric acid in control of anterior pituitary hormone release. In: Costa E., DiChiara G., Gessa G.L. (Eds.), Gaba and benzodiazepine receptors, advances in biochemical psychopharmacology. Raven Press, New York, 1981, vol. 26, p. 237.

    CAS  Google Scholar 

  56. Vijayan E., Samson W.K., McCann S.M. In vivo and in vitro effects of cholecystokinin on gonadotropin, prolactin, growth hormone and thyrotropin release in the rat. Brain Res. 172: 295, 1979.

    Article  PubMed  CAS  Google Scholar 

  57. McCann S.M. Control of anterior pituitary hormone release by brain peptides. Neuroendocrinology 31: 355, 1980.

    Article  PubMed  CAS  Google Scholar 

  58. Samson W.K., Burton K.P., Reeves J.P., McCann S.M. Vasoactive intestinal peptide stimulates LHRH release from median eminence synaptosomes. Regulatory Peptides 2: 253, 1981.

    Article  PubMed  CAS  Google Scholar 

  59. Lumpkin M.D., Negro-Vilar A., Franchimont P., McCann S.M. Evidence for a hypothalamic site of action of inhibin to suppress FSH release. Endocrinology 108: 1101, 1981.

    Article  PubMed  CAS  Google Scholar 

  60. Chappel S.C., Barraclough C.A. Hypothalamic regulation of pituitary FSH secretion. Endocrinology 98: 927, 1976.

    Article  PubMed  CAS  Google Scholar 

  61. Ojeda S.R., Jameson H.E., McCann S.M. Hypothalamic areas involved in prostaglandin (PG)-induced gonadotropin release. II. Effect of PGE2 and PGF2α implants on follicle stimulating hormone release. Endocrinology 100: 1595, 1977.

    Article  PubMed  CAS  Google Scholar 

  62. Lumpkin M.D., McCann S.M. Studies on the possible selective hypothalamic control of FSH secretion. Fed. Proc. 38: 1107, 1979.

    Google Scholar 

  63. Samson W.K., Snyder G., Fawcett C.P., McCann S.M. Chromatographic and biologic analysis of ME and OVLT LHRH. Peptides 1: 97, 1980.

    Article  PubMed  CAS  Google Scholar 

  64. Mizunuma H., Samson W.K., Lumpkin M.D., McCann S.M. The presence of FSH-releasing factor in the posterior portion of the rat median eminence. Neuroendocrinology (1981, submitted).

    Google Scholar 

  65. Lumpkin M.D., Negro-Vilar A., McCann S.M. Paradoxical elevation of growth hormone by intraven-tricular somatostatin: possible ultrashort-loop feedback. Science 211: 1072, 1981.

    Article  PubMed  CAS  Google Scholar 

  66. Ojeda S.R., Negro-Vilar A., McCann S.M. Release of prostaglandin Es by hypothalamic-induced luteinizing hormone-releasing hormone release. Endocrinology 104: 617, 1979.

    Article  PubMed  CAS  Google Scholar 

  67. Moss R.L., McCann S.M. Induction of mating behavior in rats by luteinizing hormone releasing factor. Science 181: 177, 1973.

    Article  PubMed  CAS  Google Scholar 

  68. Moss R.L., Foreman M.M. Potentiation of lordosis behavior by intrahypothalamic infusion of synthetic luteinizing hormone-releasing hormone. Neuroendocrinology 20: 176, 1976.

    Article  PubMed  CAS  Google Scholar 

  69. Moss R.L., Dudley C.A. Hypothalamic peptides and sexual behavior. In: Friedman R.C. (Ed.), Behavior and the menstrual cycle. Marcel Dekker, New York (in press).

  70. Kozlowski G.P., Hostetter G. Cellular and subcellular localization and behavioral effects of gonadotropin-releasing hormone (Gn-RH) in the rat. In: Scott D.E., Kozlowski G.P., Weindl A. (Eds.), Brain-Endocrine interaction III. Neural hormones and reproduction. Karger, Basel, 1978, p. 138.

    Google Scholar 

  71. Harwood J.P., Clayton R.N., Catt K.J. Ovarian gonadotropin-releasing hormone receptors. I: Properties and inhibition of luteal cell function. Endocrinology 107: 407, 1980.

    Article  PubMed  CAS  Google Scholar 

  72. Bambino T.H., Schreiber J.R., Hsueh A.J.W. Gonadotropin-releasing hormone and its agonist inhibit testicular luteinizing hormone receptor and steroidogenesis in immature and adult hypophysectomized rats. Endocrinology 107: 908, 1980.

    Article  PubMed  CAS  Google Scholar 

  73. Ge L.-J., Pedroza E., Nekola M.V., Coy D.H., Schally A.V. In vivo and in vitro binding of LHRH and its analogs by extrapituitary tissues. In: Mahesh V.B., Muldoon T.G., Saxena B.B., Sadler W.A. (Eds.), Functional correlates of hormone receptors in reproduction. Elsevier-North-Holland, New York, 1980, p. 493.

    Google Scholar 

  74. Hsueh A.J.W., Erickson G.F. Extra pituitary inhibition of testicular function by LHRH. Nature 281: 66, 1979.

    Article  PubMed  CAS  Google Scholar 

  75. Clayton R.N., Harwood J.P., Catt K.J. Gonadotropin releasing hormone analog binds to luteal cells and inhibits progesterone production. Nature 282: 90, 1979.

    Article  PubMed  CAS  Google Scholar 

  76. Clark M.R., Hillensjo T., Marsh J.M., LeMaire W.J. Hormonal regulation of prostaglandin synthesis in rat granulosa ceHs. In: Mahesh V.B., Muldoon T.G., Saxena B.B., Sadler W.A. (Eds.), Functional correlates of hormone receptors in reproduction. Elsevier-North-Holland, New York, 1981, p. 275.

    Google Scholar 

  77. Ekholm C., Hillensjo T., Isaksson O. Gonadotropin releasing hormone agonists stimulate oocyte meiosis and ovulation in hypophysectomized rats. Endocrinology 108: 2022, 1981.

    Article  PubMed  CAS  Google Scholar 

  78. Kawakami M., Kubo K., Uemura T., Nagase M., Hayashi R. Involvement of ovarian innervation in steroid secretion. Endocrinology 109: 136, 1981.

    Article  PubMed  CAS  Google Scholar 

  79. Gerendai I., Rotsztejn W., Marchetti B., Kordon C., Scapagnini U. Unilateral ovariectomy-induced luteinizing hormone-releasing hormone content changes in the two halves of the mediobasal hypothalamus. Neurosci. Lett. 9: 333, 1978.

    Article  PubMed  CAS  Google Scholar 

  80. Sohally A.V., Comaru-Schally A.M., Kastin A.J. Present status of the use of LH-RH and its analogs in the diagnosis and therapy of infertility. In:. Beling C.G., Wentz A.C. (Eds.), The LH releasing hormone. Masson, New York, 1981, p. 1.

    Google Scholar 

  81. Potashnik G., Homburg R., Eshkol A., Insler V., Lunenfeld B. Hormonal and clinical responses in amenorrheic patients treated with gonadotropins and nasal form of synthetic gonadotropin-releasing hormone. Fertil. Steril. 29: 148, 1978.

    PubMed  CAS  Google Scholar 

  82. Leyendecker G., Wildt L., Hansmann M. Pregnancies following chronic intermittent (pulsatile) administration of GN-RH by means of a portable pump (zyklomat) — a new approach to the treatment of infertility in hypothalamus and amenorrhea. J. Clin. Endocrinol. Metab. 51: 1214, 1980.

    Article  PubMed  CAS  Google Scholar 

  83. Hanker J.P., Bohnet H.G., Schenider H.P.G. Nasal spray assisted pulsatile LHRH in the treatment of hypothalamic amenorrhea. Neuroendocrinology Letters 2: 269, 1980.

    Google Scholar 

  84. Seegar Jones G., Wentz A.C., Rosenwaks Z. LH-RH test before and during clomiphene treatment in the elucidation of the positive and negative estrogen feedback. In: Beiling C.G., Wentz A.C. (Eds.), The LH releasing hormone. Masson, New York, 1981, p. 193.

    Google Scholar 

  85. Crowley W.F., McArthur J.W. Stimulation of the normal menstrual cycle in Kalman’s syndrome by pulsatile administration of luteinizing hormone releasing hormone. J. Clin. Endocrinol. Metab. 51: 173, 1980.

    Article  PubMed  Google Scholar 

  86. Crowley W.F., Comite F., Vale W., Rivier J., Loriaux D.L., Cutler G.B., Therapeutic use of pituitary desensitization with a long acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J. Clin. Endocrinol. Metab. 52: 370, 1981.

    Article  PubMed  Google Scholar 

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  1. Department of Physiology, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235, USA

    S. M. McCann

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Lecture presented at the University of Florence on the 10th anniversary of the passing of Prof. A. Lunedei.

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McCann, S.M. Progress in neuroendocrinology: LH releasing (LHRH), basic and clinical aspects. J Endocrinol Invest 6, 243–251 (1983). https://doi.org/10.1007/BF03350615

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