Abstract
Plasma levels and 24-h urinary excretion of cyclic AMP and cyclic GMP were measured in 18 patients with hyperthyroidism, 7 patients with hypothyroidism and 25 normal subjects. Mean plasma and urinary levels of both cyclic AMP and cyclic GMP were significantly higher in the hyperthyroid than in the normal subjects. In the hyperthyroid patients significant positive correlations between the serum thyroid hormone levels and plasma and urinary cyclic nucleotide concentrations were also found, suggesting that the elevated extracellular cyclic nucleotide levels in hyperthyroidism are probably a consequence of increased secretion of thyroid hormones. In the hypothyroid patients the extracellular cyclic nucleotide concentrations did not differ significantly from those of the normal subjects.
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References
Levey G.S., Epstein S.E. Myocardial adenyl cyclase: activation by thyroid hor-mones and evidence for two adenyl cyclase systems. J. Clin. Invest. 48: 1663, 1969.
Mandel L.R., Kuehl F.A. Jr. Lipolytic action of 3,3′5-triiodo-l-thyronine, a cyclic AMP phosphodiesterase inhibitor. Biochem. Biophys. Res. Commun. 28: 13, 1967.
Thanassi N.M., Newcombe D.S. Cyclic AMP and thyroid hormone: inhibition of epiphyseal cartilage cyclic 3′,5′-nucleotide phosphodiesterase activity by l-triiodothyronine. Proc.Soc. Exp. Biol. Med. 147: 710, 1974.
Marcus R. Cyclic nucleotide phosphodiesterase from bone: characterization of the enzyme and’studies of inhibition by thyroid hormones. Endocrinology 96: 400, 1975.
Krishna G., Hynie S., Brodie B.B. Effect of thyroid hormones on adenyl cyclase in adipose tissue and on free fatty acid mobilization. Proc. Natl. Acad. Sci. USA 59: 884, 1968.
Levey G.S., Skelton C.L., Epstein S.E. Decreased myocardial adenyl cyclase activity in hypothyroidism. J. Clin. Invest. 48: 2244, 1969.
Armstrong K.J., Stouffer J.E., Van Inwegen R.G., Thompson W.J., Robison G.A. Effects of thyroid hormone deficiency on cyclic adenosine 3′:5′-monophosphate and control of lipolysis in fat cells. J. Biol. Chem. 249: 4226, 1974.
Van Inwegen R.G., Robison G.A., Thompson W.J., Armstrong K.J., Stouffer J.E. Cyclic nucleotide phosphodiesterases and thyroid hormones. J. Biol. Chem. 250: 2452, 1975.
Sobel B.E., Dempsey P.J., Cooper T. Normal myocardial adenyl cyclase activity in hyperthyroid cats. Proc. Soc. Exp. Biol. Med. 132: 6, 1969.
Levey G.S., Skelton C.L., Epstein S.E. Influence of hyperthyroidism on the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state. Endocrinology 85: 1004, 1969.
Caldwell A., Fain J.N. Triiodothyronine stimulation of cyclic adenosine 3′,5′-monophosphate accumulation in fat cells. Endocrinology 89: 1195, 1971.
Jones J.K., Ismail-Beigi F., Edelman I.S. Rat liver adenyl cyclase activity in various thyroid states. J. Clin. Invest. 51: 2498, 1972.
Fernandez-Pol J.A., Hays M.T. Alterations in cyclic nucleotides in dogs after triiodothyronine. Acta Endocrinol. (Kbh.) 79: 66, 1975.
Karlberg B.E., Henriksson K.G., Andersson R.G.G. Cyclic adenosine 3′,5′-monophosphate concentration in plasma, adipose tissue and skeletal muscle in normal subjects and in patients with hyper-and hypothyroidism. J. Clin. Endocrinol. Metab. 39: 96, 1974.
Guttler R.B., Shaw J.W., Otis C.L., Nicoloff J.T. Epinephrine-induced alterations in urinary cyclic AMP in hyper-and hypothyroidism. J. Clin. Endocrinol. Metab. 41: 707, 1975.
Elkeles R.S., Lazarus J.H., Siddle K., Campbell A.K. Plasma adenosine 3′,5′-cyclic monophosphate response to glucagon in thyroid disease. Clin. Sci. 48: 27, 1975.
Guttler R.B., Croxon M.S., Dequattro V.L., Warren D.W., Otis C.L., Nicoloff J.T. Effects of thyroid hormone on plasma adenosine 3′,5′-monophosphate production in man. Metabolism. 26: 1155, 1977.
Madsen S.N. Thyroid function and plasma cyclic AMP response to intravenous glucagon. Acta Endocrinol. (Kbh.) 85: 760, 1977.
Okada F., Ide H., Hata S., Honma M., Ui M. Plasma cyclic nucleotide responses to insulin-induced hypoglicaemia and methacholine in patients with hyperthyroidism. Eur. J.Clin. Invest. 10: 81, 1980.
Rosen O.M. Urinary cyclic AMP in Graves’ disease. N.Engl. J. Med. 287: 670, 1972.
Lin T., Kopp L.E., Tucci J.R. Urinary excretion of cyclic-3′,5′-adenosine monophosphate in hyperthyroidism. J. Clin. Endocrinol. Metab. 36: 1033, 1973.
Tucci J.R., Kopp L. Urinary cyclic nucleotide levels in patients with hyper- and hypothyroidism. J. Clin. Endocrinol. Metab. 43: 1323, 1976.
Carter D.J., Heath D.A. The effect of treatment of hyper- and hypothyroidism on urinary excretion of cyclic adenosine 3′,5′-monophosphate. Acta Endocrinol. (Kbh.) 84: 542, 1977.
De Nutte N., Demeester-Mirkine N., Six R., Corvilain J., De Backer M. Urinary cyclic AMP in hyperthyroidism. Horm. Metab. Res. 10: 315, 1978.
Lin T. Plasma cyclic nucleotide levels in hyperthyroidism. Acta Endocrinol. (Kbh.) 90: 62.1979.
Nilsson O.R., Andersson R.G.G., Karlberg B.E. Effects of propranolol and atenolol on plasma and urinary cyclic adenosine 3′,5′-monophosphate in hyper-thyroid patients. Acta Endocrinol. (Kbh.) 94: 38, 1980.
Bonsnes R.W., Taussky H.H. On the colorimetric determination of creatinine by Jaffe reaction. J. Biol. Chem. 158: 581, 1945.
Kramer C.Y. Extension of multiple range tests to group means with unequal numbers of replication. Biometrics 12: 307, 1956.
Wray H.L., Burman K.D., Smallridge R.C., Alford J.P., Butler V.M., Wright F.D., Wartofsky L. Effect of 3,5,3′-triiodothyronine and 3.3′.5′-triiodothyro-nine administration on serum tri-, di-, and monoiodo-thyronines and plasma cyclic nucleotides in sheep. Endocrinology 107: 130, 1980.
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Peracchi, M., Bamonti-Catena, F., Lombardi, L. et al. Plasma and urine cyclic nucleotide levels in patients with hyperthyroidism and hypothyroidism. J Endocrinol Invest 6, 173–177 (1983). https://doi.org/10.1007/BF03350603
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DOI: https://doi.org/10.1007/BF03350603