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Maternal serum hormone changes during abortion induced with 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2

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Abstract

Serum hormone levels in women undergoing successful first and second trimester abortions induced by 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2 vagitories have been measured. Significantly decreased levels of prolactin (p<0.01) and TSH (p<0.05) were seen in both groups of women but the drop appeared sooner, within two hours, in first trimester abortions. Regardless of gestational length there was a significant decrease in serum human chorionic gonadotropin (hCG) (p<0.01) concentrations in maternal serum six hours into treatment. In the second trimester abortions total estriol, α-fetoprotein and lactoplacental hormone hPL were analysed in maternal serum but the levels did not change over the eight hour investigation period. It is speculated that the PGE2-derivative most likely affects the maternal pituitary secretion of prolactin and TSH, possibly via direct or indirect interference with TRH mechanism(s).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Karolinska Hospital, S-104 01, Stockholm, Sweden

    K. Bremme, P. Eneroth & M. Bygdeman

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  1. K. Bremme
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  2. P. Eneroth
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  3. M. Bygdeman
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Bremme, K., Eneroth, P. & Bygdeman, M. Maternal serum hormone changes during abortion induced with 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2 . J Endocrinol Invest 5, 387–391 (1982). https://doi.org/10.1007/BF03350538

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