Skip to main content
Log in

Gigantism and hyperprolactinemia in polyostotic fibrous dysplasia (Mc Cune — Albright syndrome)

  • Case Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

A case of Mc Cune-Albright syndrome is presented with the unusual combination of gigantism and hyperprolactinemia. Dynamic exploration of the endocrine functions suggests the presence of an autonomous pituitary adenoma as the cause of the abnormal hormonal findings. These were successfully normalized by radiotherapy to the pituitary gland.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Lightner E.S., Penny R., Frasier S.D. Growth hormone excess and sexual precocity in polyostotic fibrous dysplasia (Mc Cune-Albright syndrome): Evidence for abnormal hypothalamic function. J. Pediatr. 87: 922, 1975.

    Article  PubMed  CAS  Google Scholar 

  2. Joisby S.K., Morrow L.B. Mc Cune-Albright syndrome associated with a functioning pituitary chromophobe adenoma. J. Pediatr. 88: 73, 1976.

    Article  Google Scholar 

  3. Powell D.G.B. Polyostotic fibrous dysplasia with acromegaly (Albright’s syndrome). S. Afr. Med. J. 50: 182, 1976.

    PubMed  CAS  Google Scholar 

  4. Carr D., Mathie I.K., Manners A.R., Colman C. Hyperprolactinaemia in a patient with the Mc Cune-Al bright syndrome. Br.J. Obstet. Gynaecol. 86: 330, 1979.

    Article  PubMed  CAS  Google Scholar 

  5. Hall R., Warrick C. Hypersecretion of hypothalamic releasing hormone: A possible explanation of the endocrine manifestations of polyostotic fibrous dysplasia (Albright’s syndrome). Lancet 1: 1313, 1972.

    Article  PubMed  CAS  Google Scholar 

  6. Di George A.M. Albright’s syndrome: Is it coming of age? J. Pediatr. 87: 1018, 1975.

    Article  PubMed  Google Scholar 

  7. Lengyel A.M., Chacra A.R., Vieira J.G.H., Zampieri M., Russo E.M.K. Dynamic evaluation of prolactin secretion in acromegaly. In: McLeod R.M., Scapagnini V. (Eds.), Central and peripheral regulation of prolactin function. Raven Press, New York, 1980, p. 377.

    Google Scholar 

  8. Werder K. von, Eversmann T., Fahlbuseh R., Rjosk H.K. Treatment of hyperprolactinemia. In: McLeod R.M., Scapagnini V. (Eds.), Central and peripheral regulation of prolactin. Raven Press, New York, 1980, p. 253.

    Google Scholar 

  9. Carmina E., LoCoco R., Longo R.A., Lausara P., Jami A. Effect of acute administration of antidopaminergic drugs on prolactin secretion in acromegaly. In: McLeod R.M., Scapagnini V. (Eds.), Central and peripheral regulation of prolactin. Raven Press, New York, 1980, p. 353.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Polychronakos, C., Tsoukas, G., Ducharme, J.R. et al. Gigantism and hyperprolactinemia in polyostotic fibrous dysplasia (Mc Cune — Albright syndrome). J Endocrinol Invest 5, 323–326 (1982). https://doi.org/10.1007/BF03350521

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03350521

Key-words

Navigation