Journal of Endocrinological Investigation

, Volume 4, Issue 2, pp 185–188 | Cite as

Effects of synthetic salmon calcitonin administration on gastrin, immunoreactive insulin and growth hormone release after protein meal in uremic patients

  • Michele Lunetta
  • E. Infantone
  • D. Spanti
  • L. Mughini


Recent studies indicate that calcitonin inhibits, in man, the secretion of several hormones such as gastrin, insulin, growth hormone. There are no reports about this effect in uremic patients in which frequently calcitonin, gastrin, growth hormone, and insulin response to glucose administration is increased. A comparative study of the effects of synthetic salmon calcitonin infusion (50 U iv) on gastrin, growth hormone and insulin release after protein meal (250 g of boiled lean beef) in 10 uremic patients undergoing hemodialysis and in 10 normal subjects was performed. Insulin and growth hormone response to protein meal was inhibited by calcitonin both in normal and uremic subjects. Gastrin response instead was inhibited only in normal subjects. These findings indicate that in uremic patients the inhibitory effect of calcitonin on insulin and growth hormone secretion is still present. The lack of evident inhibitory effect on gastrin release could be related to persistent hypergastrinemia because of the increased half life of the hormone which could mask acute changes of secretion.


Calcitonin gastrin immunoreactive insulin growth hormone uremia protein meal 


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  1. 1.
    Blahos J., Svoboda Z., Höschl C. The effect of calcitonin on glucose metabolism. Endokrinologie 68: 226, 1976.PubMedGoogle Scholar
  2. 2.
    Passeri M., Carapezzi C, Ceccato S., Cucinotta D., Palummeri E. Influenza della calcitonina sulla increzione insulinica da carico di glucosio per via endovenosa. Giornate Cliniche Mediche 55: 362, 1973.Google Scholar
  3. 3.
    Petralito A., Lunetta M., Liuzzo A., Fiore C.E., Giuga G., Heynen G. Effects of salmon calcitonin on blood glucose and insulin levels under basal conditions and on intravenous glucose tolerance test. J. Endocrinol. Invest. 2: 209, 1979.PubMedCrossRefGoogle Scholar
  4. 4.
    Ziegler R., Bellwinkel S., Schmidtchen D., Minne H. Effects of hypercalcemia and calcitonin on glucose stimulated insulin secretion in man. Horm. Metab. Res. 4: 60, 1972.PubMedCrossRefGoogle Scholar
  5. 5.
    Cantalamessa L., Catania A., Reschini E., Peracchi M. Inhibitory effect of calcitonin on growth hormone and insulin secretion in man. Metabolism 27: 987, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Mangiafico R.A., Lunetta M., Liuzzo A., Costa M., Giuga G., Bonanno G.C. Influenza della calcitonina di salmone sulla somatotro-pinemia e sulla glucagonemia dopo stimolo con insulina endovena. Boll. Soc. Med. Chir. (Catania), 47: 367, 1978.Google Scholar
  7. 7.
    Bieberdorf F.A., Gray T.K., Walsh J.A., Fordtran J.S. Effect of calcitonin on meal-stimulated gastric acid secretion and serum gastrin concentration. Gastroenterology 66: 343, 1974.PubMedGoogle Scholar
  8. 8.
    Bolman R.M., Cooper C.W., Garner S.C., Munson P.L., Wells S.A. Stimulation of gastrin secretion in the pig by parathyroid hormone and its inhibition by calcitonin. Endocrinology 100: 1014, 1977.PubMedCrossRefGoogle Scholar
  9. 9.
    Oyama T., Shiraki M., Ito H., Tanaka K., Orimo H. Calcitonin inhibition of gastrin secretion in man. Endocrinol. Jpn. 20: 625, 1973.PubMedCrossRefGoogle Scholar
  10. 10.
    Heynen G., Kanis J.A., Oliver D., Ledingham J.G.G., Russel R.G.G. Evidence that endogenous calcitonin protects against renal bone disease. Lancet 2: 1322, 1976.CrossRefGoogle Scholar
  11. 11.
    Silva O.L., Becker K.L., Shalhoub R.J., Snider R.H., Bivins L.E., Moore C.F. Calcitonin levels in chronic renal disease. Nephron 19: 12, 1977.PubMedCrossRefGoogle Scholar
  12. 12.
    Defronzo R.A. Pathogenesis of glucose intolerance in uraemia. Metabolism 27: (Suppl. 2), 1866, 1978.Google Scholar
  13. 13.
    Orskov H., Christensen N.J. Growth hormone in uremia. Scand. J. Clin. Lab. Invest. 27: 51, 1971.CrossRefGoogle Scholar
  14. 14.
    Korman M.G., Laver M.C., Hansey J. Hypergastrinemia in chronic renal failure. Br. Med. J. 1: 209, 1972.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Sullivan S.N., Tustanoff E., Slaughter D.N., Linton A.L., Lindsay R.M., Watson W.C. Hypergastrinemia and gastric acid hypersecretion in uraemia. Clin. Nephrol. 5: 25, 1976.PubMedGoogle Scholar
  16. 16.
    Walsh J.H., Grossman M.I. Gastrin N. Engl. J. Med. 292: 1324, 1975.CrossRefGoogle Scholar
  17. 17.
    Hutching R.H., Hagstrom R.M., Schribner B.H. Glucose intolerance in patients on long-term intermittent dialysis. Ann. Intern. Med. 65: 275, 1966.CrossRefGoogle Scholar
  18. 18.
    National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039, 1979.CrossRefGoogle Scholar
  19. 19.
    Herbert V., Lau K.S., Gottlieb C.W., Bleicher S.J. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. Metab. 25: 1375, 1965.PubMedCrossRefGoogle Scholar
  20. 20.
    Le Portz J. Le dosage radioimmunologique de la gastrine. Thèse Doc. Méd. Nantes, 1975.Google Scholar
  21. 21.
    Molinatti G.M., Massara F., Pennisi F., Scassellati G.A., Strumia E., Vancheri L. Radioimmunoassay of growth hormone. J. Nucl. Biol. Med. 13: 26, 1969.PubMedGoogle Scholar
  22. 22.
    Borie A.B. Regulation of the mitochondrial control of cellular calcium homeostasis and calcium transport by phosphate, parathyroid hormone, calcitonin, vitamin D and cyclic AMP. In: Talmage R.V., Owen M., Parson J.A. (Eds.), Calcium regulating hormones. Excerpta Medica, Amsterdam, 1975, p. 217.Google Scholar
  23. 23.
    Ajlouni K., Hagen T.C. The effect of acute hypercalcemia on growth hormone release in man. J. Clin. Endocrinol. Metab. 40: 780, 1975.PubMedCrossRefGoogle Scholar
  24. 24.
    Mac Leod R.M., Fontham E.H. Influence of ionic environment on the in vitro synthesis and release of pituitary hormones. Endocrinology 86: 863, 1970.CrossRefGoogle Scholar
  25. 25.
    Kuzuya T.H., Kajinuma T.I. Effects of intrapancreatic injection of potassium and calcium on insulin and glucagon secretion in dogs. Diabetes 23: 55, 1974.PubMedGoogle Scholar
  26. 26.
    Reeder D.D., Jackson B.M., Ban J., Clemdinnen B.G., Davidson W.D., Thompson J.C. Influence of hypercalcemia on gastric acid secretion and serum gastrin concentration in man. Ann. Surg. 172: 540, 1970.PubMedCentralPubMedCrossRefGoogle Scholar
  27. 27.
    Becker H.D., Reeder D.D., Scurry M.T., Thompson J.C. Inhibition of gastrin release and gastric secretion by calcitonin in patients with peptic ulcer. Am. J. Surg. 127: 71, 1974.PubMedCrossRefGoogle Scholar
  28. 28.
    Fahrenkrug J., Hornum I., Rehfeld J.F. Effect of calcitonin on serum gastrin concentration and component pattern in man. J. Clin. Endocrinol. Metab. 41: 149, 1975.PubMedCrossRefGoogle Scholar
  29. 29.
    Grossman M.I. Biological actions of gastrin. Demling L. Thieme Verlag, Stuttgart, 1968.Google Scholar
  30. 30.
    Maxwell J.C., Moore J.G., Dixon J. Gastrin levels in anephric patients. Surforum 22: 305, 1971.Google Scholar
  31. 31.
    Dent R.I., James J.H., Wang C., Deftos L.J., Talamor R., Fisher J.E. Hyperparathyroidism gastric acid secretion and gastrin. Ann. Surg. 176: 360, 1972.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Endocrinology (SIE) 1981

Authors and Affiliations

  • Michele Lunetta
    • 1
  • E. Infantone
    • 1
  • D. Spanti
    • 1
  • L. Mughini
    • 1
  1. 1.Istituto di Malattie del Ricambio, Cattedra di NefrologiaUniversità di Catania, Ospedale GaribaldiCataniaItaly

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