Abstract
Plasma growth hormone (GH) levels were measured before and after oral administration of L-dopa in 8 insulin-dependent juvenile diabetic patients, and in 6 non insulin-dependent maturity-onset diabetics, while they were hyperglycemic, and values were compared with those of normal children and adult subjects. Maturity-onset diabetics failed to show an increase in serum GH levels after L-dopa administration, while serum peak GH values of juvenile diabetic patients were not significantly different from those of normal adults and children. Hyperglycemia thus failed to prevent L-dopa induced growth hormone response in insulin-dependent juvenile diabetic patients.
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Laron Z., Josefsberg Z., Doron M. Effect of L-dopa on the secretion of plasma growth hormone in children and adolescents. Clin. Endocrinol. (Oxf) 2:1, 1973.
Morabito F., Velardo A., Barbarino A., Pasargiklian E. Plasma GH levels after L-dopa in prepuberal normal children and in pituitary dwarfs. Ann. Endocrinol. (Paris) 35: 527, 1974.
Boyd A.E., Lebovitz H.E., Pfeiffer J.B. Stimulation of growth hormone secretion by L-dopa. N. Engl. J. Med. 283: 1425, 1970.
Boden G., Owen O.E., Gulati S.C. The influence of L-dopa on release of anterior pituitary hormones on man. Clin. Res. 79: 716, 1971. (Abstract)
Massara F., Camanni F. Effect of various adrenergic receptor stimulating and blocking agents on human growth hormone secretion. J. Endocrinol. 54: 195, 1972.
Troncone L., Martino F., Barbarino A., Velardo A. HGH Radioimmunoassay Glucagon and L-dopa stimulation tests. J. Nucl. Biol. Med. 17: 84, 1973.
Mims R.B., Scott C.L., Medebe O.M., Bethune J.E. Prevention of L-dopa induced Growth Hormone stimulation by hyperglycemia. J. Clin. Endocrinol. Metab. 37: 660, 1973.
Johansen K. Glucose-suppressible growth hormone release after L-dopa administration to normal subjects. Metabolism 22: 773, 1973.
Ajlouni K., Martinson D.R., Hagen T.C. Effect of glucose on the growth hormone response to L-dopa in normal and diabetics subjects. Diabetes 24: 633,1975.
Barbarino A., Martino F., Velardo A., Troncone L. Rilievi metodologici sul dosaggio radioimmunologico dell’HGH. Acta Med. Rom. 11: 43, 1973.
Herbert V., Lau K.S., Gottlieb C, Blucer S. Coated charcoal immuno-assay of insulin. J. Clin. Endocrinol. Metab. 25: 1375, 1965.
Sekhuja V., Rastogi G.K., Siali R. Growth hormone response to L-dopa in diabetes mellitus. Acta Diabetol. Lat. 13: 242,1976.
Hansen A.P. Normalization of growth horrhone hyperresponse to exercise- in juvenile diabetics after “normalization” of blood sugar. J.Clin. Invest. 50: 1806, 1971.
Burday S.Z., Fine P.H., Schalch D.S. Growth hormone secretion in response to arginine infusion in normal and diabetics subjects: relationship to blood glucose levels. J. Lab. Clin. Med. 71: 897, 1968.
Hagen T.C, Ajlouni K. Growth hormone response to oral glucose in stable and hypoglycemia-prone diabetics. Proc. Soc. Exp. Biol. Med. 149: 223, 1975.
Garlaschi C, Di Natale B., DelGuercio M.J., Caccamo A., Gargantini L, Chiumello G. Effect of physical exercise on secretion of growth hormone, glucagon, and Cortisol in obese and diabetic children. Diabetes 24: 758, 1975.
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Barbarino, A., De Marinis, L. & Martino, F. Effect of hyperglycemia on the growth hormone response to L-dopa in diabetic subjects. J Endocrinol Invest 1, 259–261 (1978). https://doi.org/10.1007/BF03350390
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DOI: https://doi.org/10.1007/BF03350390