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Effect of gestational mastectomy on postpartum gonadotropin releasing hormone and thyrotropin releasing hormone-induced luteinizing hormone and prolactin response in first lactation holstein cattle

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Abstract

First lactation Holstein cows were divided into two treatment groups to evaluate thyrotropin releasing hormone (TRH, 0.25 μg/kg body weight) and gonadotropin releasing hormone (GnRH; 200 μg) induced secretion of prolactin (PRL) and luteinizing hormone (LH) on days 7 and 16 postpartum. Disregarding treatment, LH response was greater (p <0.01) on day 16 than day 7 postpartum (7.5 ± 0.3 ng/ml on day 7 vs 10.2 ± 0.3 ng/ml serum on day 16). Mastectomized cattle had similar time for initiation of LH increase, but peak concentrations were achieved later. Peak PRL concentrations were reached 12 to 15 min after injection and returned to baseline within 2.5 h in both groups. However, intact cows had higher (p <0.01) mean serum PRL than the mastectomized cows for 1 h following injection. Peak PRL concentration was 83.3±17.6 ng/ml for mastectomized cows vs 128.0 ± 24.7 ng/ml for intact cows. It appears that udder removal allows for greater pituitary responsiveness to GnRH but diminishes PRL response to TRH suggesting the mammary gland differentially affects pituitary secretion of LH and PRL.

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Authors and Affiliations

  1. Department of Dairy Science, College of Agriculture and Life Sciences, Virginia Agricultural Experiment Station, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA

    L. C. Holt, R. M. Akers, C. J. Denbow,  F. C. Gwazdauskas & W. E. Vinson

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  1. L. C. Holt
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  2. R. M. Akers
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  3. C. J. Denbow
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  4. F. C. Gwazdauskas
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  5. W. E. Vinson
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Holt, L.C., Akers, R.M., Denbow, C.J. et al. Effect of gestational mastectomy on postpartum gonadotropin releasing hormone and thyrotropin releasing hormone-induced luteinizing hormone and prolactin response in first lactation holstein cattle. J Endocrinol Invest 14, 147–150 (1991). https://doi.org/10.1007/BF03350289

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  • DOI: https://doi.org/10.1007/BF03350289

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