Abstract
We describe a patient with acute B-lymphocyte lymphoblastic leukemia who developed laboratory changes (not detectable free thyroxine, TSH 66 μlU/ml) suggesting severe primary hypothyroidism. Histological examination at autopsy showed massive leukemic infiltration of the thyroid gland: the progressive reduction of thyroid hormone levels with concomitant increase in TSH levels observed over a three-month period from the onset of the hemopathy suggests a cause-effect relationship between leukemic infiltration of the thyroid gland and hypothyroidism.
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Foresti, V., Parisio, E., Scolari, N. et al. Primary hypothyroidism due to leukemic infiltration of the thyroid gland. J Endocrinol Invest 11, 43–45 (1988). https://doi.org/10.1007/BF03350094
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DOI: https://doi.org/10.1007/BF03350094