Abstract
Norepinephrine (NE) failed to increase thyroid hormone release in mice when endogenous TSH secretion had been greatly reduced by a variety of means. This was demonstrated by radioiodine release in mice pretreated with 131I and with thyroxine (T4) or 3,5,3′ triiodothyronine (T3. by radioimmunoassay (RIA) in mice pretreated with 131I and T3, and in mice which had been hypophysectomized, or where TSH secretion had been decreased by prolonged administration of exogenous TSH. T4 could not be measured by RIA in mice pretreated with T4.
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References
Maayan M.L. Debons A.F., Krimsky I. Inhibition of thyrotropin and dibutyryl cyclic AMP-induced secretion of thyroxine and triiodothyronine by catecholamines. Endocrinology 101: 284, 1977.
Maayan M.L., Debons A.F., Volpert E.M., Krimsky I. Catecholamine inhibition of thyrotropin-induced secretion of thyroxine: mediation by an alpha-adrenergic receptor. Metabolism 26: 473, 1977.
Muraki T., Uzumaki H., Nakadate T., Kato R. Involvement of alpha-1 adrenergic receptors in the inhibitory effect of catecholamines on the thyrotropin-induced release of thyroxine by the mouse thyroid. Endocrinology 110: 51, 1982.
Ahren B. Effects of alpha-adrenoceptor agonists and antagonists on thyroid hormone secretion. Acta Endocrinol. (Kbh.) 108: 184, 1985.
Melander A., Nilsson E., Sundler F. Sympathetic activation of thyroid hormone secretion in mice. Endocrinology 90: 194, 1972.
Ahren B., Bengtsson H.V., Hedner P. Effects of norepinephrine on basal and thyrotropinstimulated hormone secretion in the mouse. Endocrinology 119: 1058, 1986.
Maayan M.L., Volpert E.M., Debons A.F. Neurotransmitter regulation of thyroid activity. Endocr. Res. 13: 199, 1987.
McKenzie J.M. The bioassay of thyrotropin in serum. Endocrinology 63: 372 1958.
Collip J.P., Anderson E.M. Studies on thyrothropic hormone of anterior pituitary. JAMA 104: 965, 1935.
Maayan M.L. Effect of growth hormone and thyrotropin upon deiodination of diiodotyrosine by hypophysectomized rat thyroid and liver. Endocrinology 78: 471, 1966.
Gafni M., Sirkis N., Gross J. Inhibition of the response of mouse thyroid to thyroiropin induced by chronic triiodothyronine treatment. Endocrinology 97: 1256, 1975.
Werner S.C., Segal B.C., Osserman E.F. Immunologic and biologic characterization of antisera to beef thyrotropin preparations. J. Clin. Invest. 40: 92, 1961.
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Maayan, M.L., Volpert, E.M. Norepinephrine and TSH: effects on thyroidal radioiodine and thyroxine release. J Endocrinol Invest 12, 773–776 (1989). https://doi.org/10.1007/BF03350057
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DOI: https://doi.org/10.1007/BF03350057