Skip to main content
SpringerLink
Log in

Evaluation of anterior pituitary function in hypertensive patients following inhibition of angiotensin II generation

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

The Authors investigated anterior pituitary function in hypertensive patients in basal conditions and following a 15-day course of treatment with Captopril, a drug which blocks the generation of Angiotensin II (Angio II). No differences were observed for any of the pituitary hormones except ACTH, whose response to hypoglycemia was significantly blunted by the pharmacological treatment. A possible role of Angio. II in modulating some aspects of pituitary function is proposed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fuxe K., Ganten D., Hokfelt T., Bolme P. Immunohistochemical evidence for the existence of Angiotensin II containing nerve terminals in the brain and spinal cord in the rat. Neurosci. Lett. 2: 229, 1976.

    Article  PubMed  CAS  Google Scholar 

  2. Phillips M.I., Weyhenmeyer J., Felix D., Ganten D., Hoffman W.E. Evidence for an endogenous brain renin-angiotensin system. Fed. Proc. 38: 226, 1979.

    Google Scholar 

  3. Fischer-Ferraro C., Nahmod V.E., Goldstein D.J., Finkielman S. Angiotensin and renin in rat and dog brain. J. Exp. Med. 133: 353, 1971.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  4. Elde R., Hokfelt T. Distribution of hypothalamic hormones and other peptides in the brain. In: Ganong W.F., Martini L. (Eds.), Frontiers in neuroendocrinology. Raven Press, New York, 1978, vol. 5, p. 1.

    Google Scholar 

  5. Malayan S.A., Reid I.A. Antidiuresis produced by injection of renin into the third cerebral ventricle of the dog. Endocrinology 98: 329, 1976.

    Article  PubMed  CAS  Google Scholar 

  6. Reid I.A. Actions of Angiotensin II on the brain. 7th International Congress of Endocrinology, Quebec City, Quebec, Canada. International Congress Series n. 652, p. 88 Abstract. Excerpta Medica, Amsterdam, 1984.

    Google Scholar 

  7. Uhlich E., Weber P., Eigler J., Groschel-Stewart V. Angiotensin stimulated AVP release in humans. Klin. Wochenschr. 53: 177, 1975.

    Article  PubMed  CAS  Google Scholar 

  8. Ramsay D.J., Keil L.C., Sharpe M.C., Shinsako J. Angiotensin II infusion increases vasopressin, ACTH and 11 -hydroxycorticosteroid secretion. Am. J. Physiol. 234: R66, 1978.

    PubMed  CAS  Google Scholar 

  9. Gaillard R.C., Favrod-Coune C.A., Capponi A.M., Muller A.F. Corticotropin releasing activities of the renin-angiotensin system peptides in rat and in man. Neuroendocrinology 41: 511, 1985.

    Article  PubMed  CAS  Google Scholar 

  10. Steele M.K., Negro-Vilar A., McCann S.M. Effect of Angiotensin II on in vivo and in vitro release of anterior pituitary hormones in the female rat. Endocrinology 109: 893, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Steele M.K., Ganong W.F. Brain renin-angiotensin system and secretion of luteinizing hormone and prolactin. In: Ganong W.F., Martini L. (Eds.), Frontiers in neuroendocrinology. Raven Press, New York, vol. 9, 1988, p. 83.

    Google Scholar 

  12. Aguilera G., Hyde C.L., Catt K.J. Angiotensin II receptors and prolactin release in pituitary lactotrophes. Endocrinology 111: 1045, 1982.

    Article  PubMed  CAS  Google Scholar 

  13. Malarkey B.W., Bharatni J.Z., Degroff V. Angiotensin II promotes prolactin release from normal anterior pituitary cell cultures in a calcium dependent manner. J. Clin. Endocrinol. Metab. 64: 713, 1987.

    Article  PubMed  CAS  Google Scholar 

  14. Ferguson R.K., Turini G.A., Brunner M.R., Gavras H., McKinstry D.N. A specific orally active inhibitor of angiotensin-converting enzyme in man. Lancet 1: 775, 1977.

    Article  PubMed  CAS  Google Scholar 

  15. Glorioso N., Madeddu P., Dessy’-Fulgheri P., Fois G., Palermo M., Cocco F., Dettori S., Rappelli A. Are age and the sodium intake affecting circulating inactive renin in man? In: Mantero F., Biglieri G., Edwards C.R. (Eds.), Endocrinology of hypertension. Academic Press, London, New York, 1982, p. 294.

    Google Scholar 

  16. Glorioso N., Madeddu P., Dessy’-Fulgheri P., Fois G., Palermo M., Cocco F., Oppes M., Rappeiii A. Plasma inactive renin age and sodium balance in normal subjects and in patients with essential hypertension. IRCS Med. Sci. 10: 1025, 1982.

    Google Scholar 

  17. Rayyis S.S., Horton R. Effect of Angiotensin II on adrenal and pituitary function in man. J. Clin. Endocrinol. Metab. 32: 539, 1971.

    Article  PubMed  CAS  Google Scholar 

  18. Semple P.F., Buckingham J.C., Mason P.A., Fraser R. Suppression of plasma ACTH concentration by Angiotensin II infusion in normal humans and in a subject with a steroid 17-β-hydroxylase defect. Clin. Endocrinol. (Oxf.) 10: 137, 1979.

    Article  CAS  Google Scholar 

  19. Gaillard R.C., Grossman A., Gillies G., Rees L.H., Besser G.M. Angiotensin II stimulates the release of ACTH from dispersed rat anterior pituitary cells. Clin. Endocrinol. (Oxf.) 15: 573, 1981.

    Article  CAS  Google Scholar 

  20. Capponi A.M., Favrod-Coune C.A., Gaillard R.C., Muller A.F. Binding and activation properties of Angiotensin II in dispersed rat anterior pituitary cells. Endocrinology 110: 1043, 1982.

    Article  PubMed  CAS  Google Scholar 

  21. Sobel D.O. Characterization of angiotensin-mediated ACTH release. Neuroendocrinology 36: 249, 1982.

    Article  Google Scholar 

  22. Ganong W.F., Shinsako J., Reid I.A., Keil L.C., Hoffman D.L., Zimmerman E.A. Role of vasopressin in the renin and ACTH responses to intraventricular Angiotensin II. Ann. N.Y. Acad. Sci. 394: 619, 1982.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Patologia Speciale Medica e Metodologia Clinica, University of Sassari, 07100, Sassari, Italy

    S. Magna, A. Masala, P. Madeddu, P. P. Rovasio & N. Glorioso

  2. Istituto di Patologia Speciale Medica e Metodologia Clinica, University of Ancona, 60100, Ancona, Italy

    P. Dessy-Fulgheri & A. Rappelli

Authors
  1. S. Magna
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Dessy-Fulgheri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Masala
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Madeddu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. P. Rovasio
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. Glorioso
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. Rappelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Magna, S., Dessy-Fulgheri, P., Masala, A. et al. Evaluation of anterior pituitary function in hypertensive patients following inhibition of angiotensin II generation. J Endocrinol Invest 12, 611–615 (1989). https://doi.org/10.1007/BF03350017

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03350017

Key-words

Search

Navigation