Abstract
Urinary excretion of 6-keto-PGF1α and 2,3 dinor-6-keto-PGF1α, as indices of the renal and systemic production of prostaglandins, was measured during water immersion in a group of 6 healthy volunteers both in the presence and absence of dopamine blockade by the dopamine receptor antagonist, metoclopramide. Urinary flow rate and excretion of both sodium and 6-keto-PGF1α increased during water immersion, while plasma renin activity and plasma aldosterone were reduced. Urinary kallikrein and 2,3 dinor-6-keto-PGF1α also tended to increase during water immersion. Administration of metoclopramide significantly reduced 6-keto-PGF1α and sodium excretion during water immersion, but produced no changes in plasma renin activity or in 2,3 dinor-6-keto-PGF1α. Plasma aldosterone concentrations after metoclopramide were similar to those observed in the pre-immersion period. An increased synthesis of the vasodilator and natriuretic prostacyclin in the kidney might play a role in the response to water immersion. The reduced sodium and 6-keto-PGF1α excretion observed after metoclopramide administration suggests that dopamine might induce prostacyclin synthesis in the kidney during water immersion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Epstein M. Renal effects of head-out water immersion in man: implications for an understanding of volume homeostasis. Physiol. Rev. 58: 529, 1978.
Coruzzi P., Biggi A., Musiari L., Ravanetti C., Novarini A. Renal haemodynamics and natriuresis during water immersion in normal humans. Pflügers Arch. 407: 638, 1986.
Coruzzi P., Biggi A., Musiari L., Ravanetti C., Vescovi P.P., Novarini A. Dopamine blockade and natriuresis during water immersion in normal man. Clin. Sci. 70: 523, 1986.
Coruzzi P., Biggi A., Musiari L., Ravanetti C., Novarini A. Dopamine blockade abolishes the exaggerated natriuresis of essential hypertension. J. Hypertension 5: 587, 1987.
Fitzgerald G.A., Pedersen A.K., Patrono C. Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation 76: 1074, 1983.
Minuz P., Covi G., Paluani F., Degan M., Lechi C., Corsato M., Lechi A. Altered excretion of prostaglandin and thromboxane metabolites in pregnancy. Hypertension 11: 550, 1988.
Amundsen E., Putter J., Friberger F., Knos M., Larsbraten M., Gleason G. Methods for the determination of glandular kallikrein by means of a chromogenic tripeptide substrate. Adv. Exp. Med. Biol. 120: 83, 1979.
Dunn M. Renal prostaglandins. In: Dunn M. (Ed.), Renal endocrinology. Williams and Wilkins, Baltimore, 1983, p. 1.
Epstein M., Lifschitz M.D., Hoffman D.S. Relationship between renal prostaglandins E2 and renal sodium handling during water immersion in normal man. Circ. Res. 45: 71, 1979.
Schlondorff D. Renal prostaglandins. In: Dunn M. (Ed.), Renal endocrinology. Williams and Wilkins, Baltimore, 1983, p. 1.
Schnermann J., Briggs J.P., Weber P.C. Tubuloglomerular feed-back, prostaglandins and angiotensin in the auto-regulation of glomerular filtration rate. Kidney Int. 25: 53, 1984.
Krishna G.G., Danovitch G.M., Sowers J.R. Catecholamine responses to central volume expansion produced by head-out water immersion and saline infusion. J. Clin. Endocrinol. Metab. 56: 998, 1983.
Epstein M., Katsikas J.L., Duncan D.C. Role of mineralcorticoids in the natriuresis of water immersion in normal man. Circ. Res. 32: 228, 1973.
O’Hare J.P., Watson M., Penney M.D., Hampton D., Roland J.M., Corrall R.J.M. Urinary prostaglandin E2 and antidiuretic hormone during water immersion in man. Clin. Sci. 69: 493, 1985.
Ogihara T., Shima J., Hara H., Tabuchi Y., Hashizuma K., Nagano M., Katahira K., Kangawa K., Matsuo H., Kumahare Y. Significant increase in plasma immunoreactive atrial natriuretic polypeptide concentration during headout water immersion. Life Sci. 38: 2413, 1987.
Bennett E.D., Tighe D., Wegg W. Abolition by dopamine blockade of the natriuretic response produced by lower body positive pressure. Clin. Sci. 63: 361, 1982.
Horton P., Nadler J., Manogian C., Lee F. Prostacyclin is a key mediator of the vasodilator action of dopamine in humans. In: Samuelsson B., Paoletti R., Ramwell P.W. (Eds.), Advances in prostaglandin, thromboxane and leukotriene research. Raven Press, New York, 1987, p. 753.
Cooper C.L., Shaffer J.E., Malik K.U. Mechanisms of action of angiotensin II and bradykinin on prostaglandin synthesis and vascular tone in the isolated rat kidney. Circ. Res. 56: 97, 1985.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Minuz, P., Coruzzi, P., Paluani, F. et al. Increased urinary 6-keto-PGF1α excretion during water immersion is blunted by metoclopramide in normal man. J Endocrinol Invest 12, 597–600 (1989). https://doi.org/10.1007/BF03350011
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03350011