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Adrenergic blocking agents and lipoprotein lipase activity

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Abstract

Lipoprotein lipase activity, total serum cholesterol and triglycerides, HDL cholesterol were determined before and after two weeks of treatment with a low dose of an α1-blocking agent (prazosin) or of a β-adrenergic-blocking drug (metoprolol). Lipoprotein lipase activity was almost doubled after prazosin (p < 0.02) and practically unchanged after metoprolol, at a time and at a drug dosage when only minor changes in blood pressure and serum lipids were detectable. HDL cholesterol was slightly but significantly increased after prazosin (p < 0.05). Heart rate was increased after prazosin (p<0.05) and decreased after metoprolol (p<0.01).

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References

  1. Van Brummelen P. The relationship of intrinsic sympathomimetic activity for beta blocker induced changes in plasma lipids. J. Cardiovasc. Pharmacol. 5 (Suppl. 1): 551, 1983.

    Google Scholar 

  2. Ferrara L.A., Marotta T., Scilla A., Mastranzo Strazzullo P., Mancini M. Effects of oxprenolol and metoprolol on serum lipid concentration. Eur. J. Clin. Pharmacol. 26: 331, 1984.

    Article  PubMed  CAS  Google Scholar 

  3. Leren P., Foss O.P., Helgeland A., Hjermann I., Holme I., Lund Larsen P.G. Effect of propranolol and prazosin on blood lipids. The Oslo study. Lancet 2: 4, 1980.

    Article  PubMed  CAS  Google Scholar 

  4. Takabatake T., Ohta H., Mackawa M., Yamamoto Y., Ishida Y., Hara H., Hattori N. Effects on long term Prazosin therapy on lipoprotein metabolism in hypertensive patients. Am. J. Med. 76 (Suppl. 2A): 113, 1984.

    Article  PubMed  CAS  Google Scholar 

  5. Ferrara L.A, Marotta T., Rubba P., De Simone B., Leccia G., Soro S., Mancini M. Effects of alpha-adrenergic and beta-adrenergic receptor blockade on lipid metabolism. Am. J. Med. 80:104, 1986.

    Article  PubMed  CAS  Google Scholar 

  6. Oriente P., Di Marino, Mastranzo P., lovine C., Patti L. Simultaneous determination of cholesterol and triglycerides in serum and lipoprotein fractions with enzymatic automated methods. In: Burlina A., Galzigna L. (Eds.), Clinical Enzymiology. Symposium 2, Piccin Medical Books, Padova, 1979.

    Google Scholar 

  7. Kostner G.M. Enzymatic determination of cholesterol in high density lipoprotein fractions prepared by polyanion precipitation. Clin. Chem. 22:695, 1976.

    PubMed  CAS  Google Scholar 

  8. Boberg J. Quantitative determination of heparin-released lipoprotein lipase activity in human plasma. Lipids 5:452,1970.

    Article  PubMed  CAS  Google Scholar 

  9. Vessby B., Boberg J. Lypolitic activity in post-heparin plasma in man measured with different substrate emulsions. Clin. Sci. Mol. Med. 54: 201, 1978.

    PubMed  CAS  Google Scholar 

  10. Dixon W.J., Massey F.J. Introduction to Statistical Analysis. Mc Graw-Hill, New York, 1969.

    Google Scholar 

  11. Cryer A. Comparative biochemestry and physiology of Lipoprotein Lipase. In: Borensztajn J. (Ed.), Lipoprotein Lipase. Evener Publishers Inc., Chicago, 1987, p. 277.

    Google Scholar 

  12. Fain J.N., Garcia-Sainz J.A. Adrenergic regulation of adipocyte metabolism. J. Lipid Res. 24: 945, 1983.

    PubMed  CAS  Google Scholar 

  13. Eckel R.H. Adipose tissue lipoprotein lipase. In: Borensztajn J. (Ed.), Lipoprotein Lipase. Evener Publishers, Inc., Chicago, 1987, p. 79.

    Google Scholar 

  14. Uchard S.J., Lattanzio F.A., Rubin R.W., Pressman B.C. Stimulation on cathecolamine secretion from cultured chromaggin cells by an ionophore-mediated rise in intracellular sodium. J. Cell. Biol. 94: 531, 1982.

    Article  Google Scholar 

  15. Vannier C., Ez-Zoubrin A., Etienne J., Negrel R., Ailhaud G. Maturation and secretion on Lipoprotein Lipase in cultured adipose cells. J. Biol. Chem. 260: 4424, 1985.

    PubMed  CAS  Google Scholar 

  16. Chajek-Shaul T., Friedman G., Knobler H., Stein O., Etienne J., Stein Y. Importance of the different steps of glycosilation for the activity and secretion of lipoprotein lipase in rat preadipocytes studied with monensin and tunicamycin. Biochem. Biophys. Acta 827: 123, 1985.

    Article  Google Scholar 

  17. Christiansen N.J. Catecholamines and diabetes mellitus. Diabetologia 16: 211, 1979.

    Article  Google Scholar 

  18. Rubba P., Capaldo B., Falanga A., Caprio S., Rivellese A., Riccardi G., Mancini M. Plasma lipoproteins and lipoprotein lipase in young diabetics with and without ketonuria. J. Endocrinol. Invest. 8: 433, 1985.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Clinica Medica, Istituto di Medicina Interna e Malattie Dismetaboliche, II Facoltà di Medicina, University of Napoli, 80131, Napoli, Italy

    Paolo Rubba, B. De Simone, T. Marotta, G. Leccia, S. Soro & L. A. Ferrara

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  1. Paolo Rubba
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  2. B. De Simone
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  3. T. Marotta
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  4. G. Leccia
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  5. S. Soro
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  6. L. A. Ferrara
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Rubba, P., De Simone, B., Marotta, T. et al. Adrenergic blocking agents and lipoprotein lipase activity. J Endocrinol Invest 12, 119–122 (1989). https://doi.org/10.1007/BF03349937

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  • DOI: https://doi.org/10.1007/BF03349937

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