Skip to main content
Log in

Oral glucose tolerance test: an inhibitory or a stimulatory input to growth hormone secretion?

  • Opinion
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Roth J., Glick S.M., Yalow S.R., Berson S.A. Secretion of human growth hormone: physiologic and experimental modification. Metabolism 12: 577, 1963.

    PubMed  CAS  Google Scholar 

  2. Stewart P.M., Smith S., Seth J., Stewart S.E., Cole D., Edwards C.R. Normal growth hormone response to the 75 g oral glucose tolerance test measured by immunoradiometric assay. Ann. Clin. Biochem. 26: 205, 1989.

    Article  PubMed  CAS  Google Scholar 

  3. Serri O., Somma M., Comtois R., Rasio E., Beauregard H., Jilvan N., Hardy J. Acromegaly: biochemical assessment of cure after long term follow-up of transsphenoidal selective adenomectomy. J. Clin. Endocrinol. Metab. 61: 1185, 1985.

    Article  PubMed  CAS  Google Scholar 

  4. Yalow R.S., Goldsmith S.J., Berson S.A. Influence of physiologic fluctuations in plasma growth hormone on glucose tolerance. Diabetes 18: 402, 1969.

    PubMed  CAS  Google Scholar 

  5. Horton E.S., Johnson C., Lebovitz H.E. Carbohydrate metabolism in uremia. Ann. Intern. Med. 68: 63, 1968.

    Article  PubMed  CAS  Google Scholar 

  6. Grecu E.O., Walter R.M., Gold E.M. Paradoxical release of growth hormone during oral glucose tolerance test in patients with abnormal glucose tolerance. Metabolism 32: 134, 1983.

    Article  PubMed  CAS  Google Scholar 

  7. Becker M.D., Cook G.C., Wright A.D. Paradoxical elevation of growth hormone in active chronic hepatitis. Lancet 2: 1035, 1969.

    Article  PubMed  CAS  Google Scholar 

  8. Vinik A., Pimstone B., Buchanan-Lee B. Impairment of hyperglycemic induced growth hormone suppression in hyperthyroidism. J. Clin. Endocrinol. Metab. 28: 1534, 1968.

    Article  PubMed  CAS  Google Scholar 

  9. Pieters G.F.F.M., Smals A.G.H., Kloppenborg P.W.C. Defective suppression of growth hormone suppression after oral glucose loading in adolescence. J. Clin. Endocrinol. Metab. 51: 265, 1980.

    Article  PubMed  CAS  Google Scholar 

  10. Maccario M., Procopio M., Grottoli S., Oleandri S.E., Razzore P., Camanni F., Ghigo E. In obesity the Somatotrope response to either Growth Hormone-Releasing Hormone on Arginine is inhibited by somatostatin or pirenzepine but not glucose. J. Clin. Endocrinol. Metab. 80: 3774, 1995.

    PubMed  CAS  Google Scholar 

  11. Berelowitz M., Ting N.-C., Murray L. Glucopenia-mediated release of somatostatin from incubated rat hypothalamus: monosaccharide specificity and role of glycolytic intermediates. Endocrinology 124: 826, 1989.

    Article  PubMed  CAS  Google Scholar 

  12. Imaki T., Shibasaki T., Masuda A., Hotta M., Yamauchi N., Demura H., Shizume K., Wakabayashi I., Ling N. The effect of glucose and free fatty acids on growth hormone (GH)-releasing factor-mediated GH secretion in rats. Endocrinology 118: 2390, 1986.

    Article  PubMed  CAS  Google Scholar 

  13. Ghigo E., Miola C., Aimaretti G., Valente F., Procopio M., Arvat E., Yin-Zhang W., Camanni F. Arginine abolishes the inhibitory effect of glucose on the growth hormone response to growth hormone-releasing hormone in man. Metabolism 41: 1000, 1992.

    Article  PubMed  CAS  Google Scholar 

  14. Hansen A.P. The effect of intravenous glucose infusion on the exercise-induced serum growth hormone rise in normals and juvenile diabetics. Scand. J. Clin. Lab. Invest. 28: 195, 1971.

    Article  PubMed  CAS  Google Scholar 

  15. Mims R.B., Scott C.L., Modebe O.M., Bethune J.E. Prevention of L-dopa-induced growth hormone stimulation by hyperglycemia. J. Clin. Endocrinol. Metab. 37: 660, 1973.

    Article  PubMed  CAS  Google Scholar 

  16. Davies R.R., Turner S., Johnston D.G. Oral glucose inhibits growth hormone secretion induced by human pancreatic growth hormone releasing factor 1–44 in normal man. Clin. Endocrinol. 21: 477, 1984.

    Article  CAS  Google Scholar 

  17. Peñalva A., Burguera B., Casabiell X., Tresguerres J.A., Dieguez C., Casanueva F.F. Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth hormone (GH) releasing hormone-induced GH secretion in man: does acute hyperglycemia act through hypothalamic release of somatostatin? Neuroendocrinology 49: 551, 1989.

    Article  PubMed  Google Scholar 

  18. Valcavi R., Zini M., Dieguez C., Portioli I., Scanlon M.F. Effect of oral glucose on the late growth hormone rise and growth hormone responses to GHRH in normal subjects. Clin. Endocrinol. (Oxf.) 32: 539, 1990.

    Article  CAS  Google Scholar 

  19. Valcavi R., Zini M., Davoli S., Portioli I. The late growth hormone rise induced by oral glucose is enhanced by cholinergic stimulation with pyridostigmine in normal subjects. Clin. Endocrinol. (Oxf.) 37: 360, 1992.

    Article  CAS  Google Scholar 

  20. Tannenbaum G.S. Interrelationship of somatostatin and growth hormone-releasing hormone in the genesis of the rhythmic secretion of growth hormone. Acta Pediatr. Scand. 367 (Suppl.): 76, 1990.

    Article  CAS  Google Scholar 

  21. Hall R., Schally A.V., Evered D., Kastin A.J., Mortimer C.H., Tunbridge W.M.G., Besser G.M., Coy D.H., Goldie D.J., McNeilly A.S., Phenekos C., Weightman D. Action of growth hormone-release inhibitory hormone in healthy men and in acromegaly. Lancet 2: 581, 1973.

    Article  PubMed  CAS  Google Scholar 

  22. Valcavi R., Zini M. Octreotide administration, under particular temporal conditions, enhances the responses of growth hormone to growth hormone-releasing hormone in normal subjects. Clin. Endocrinol. (Oxf.) 40: 379, 1994.

    Article  CAS  Google Scholar 

  23. Valcavi R., Zini M., Volta C., Ghizzoni L., Azzarito C., Bernasconi S., Portioli I. Effects of oral glucose administration on spontaneous and growth hormone (GH)-releasing hormone-stimulated GH release in children and adults. J. Clin. Endocrinol. Metab. 79: 1152, 1994.

    PubMed  CAS  Google Scholar 

  24. Isaksson O.G., Eden S., Jansson J.O. Mode of action of pituitary growth hormone on target cells. Annu. Rev. Physiol. 47: 483, 1985.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Valcavi, R. Oral glucose tolerance test: an inhibitory or a stimulatory input to growth hormone secretion?. J Endocrinol Invest 19, 253–255 (1996). https://doi.org/10.1007/BF03349877

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03349877

Key-words

Navigation