Skip to main content
Log in

Early occurrence of a thyroid carcinoma in a patient who developed Graves’ disease after treatment for Hodgkin’s disease

  • Case Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

We report the case of a patient who developed Graves’ disease and a papillary thyroid cancer only 5 years after irradiation and adjuvant chemotherapy for Hodgkin’s disease. This case is peculiar for the very short latency time between Hodgkin’s disease treatment and thyroid cancer development, an event possibly related to Graves’ disease with elevated serum levels of TSAb. We conclude that, in patients treated for Hodgkin’s disease, continued follow-up by clinical examination and sonography of the thyroid is needed, especially if they develop Graves’ disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Nelson D.F., Reddy K.V., O’Mara R.E., Rubin P. Thyroid abnormalities following neck irradiation for Hodgkin’s disease. Cancer 42: 2553, 1978.

    Article  CAS  PubMed  Google Scholar 

  2. Hancock S.L., Cox R., McDougall I.R. Thyroid diseases after treatment of Hodgkin’s disease. N. Engl. J. Med. 325: 599, 1991.

    Article  CAS  PubMed  Google Scholar 

  3. Kaldor J.M., Day N.E., Band P., Choi N.W., Clarke E.A., Coleman M.P., Hakama M., Koch M., Langmark F., Neal F.E. Second malignancies following testicular cancer, ovarian cancer, and Hodgkin’s disease: an international collaborative study among cancer registries. Int. J. Cancer 39: 571, 1987.

    Article  CAS  PubMed  Google Scholar 

  4. Tucker M.A., Coleman C.N., Cox R.S., Varghese A., Rosemberg S.A. Risk of second cancers after treatment for Hodgkin’s disease. N. Engl. J. Med. 318: 76, 1988.

    Article  CAS  PubMed  Google Scholar 

  5. Santoro A., Bonadonna G., Bonfante V., Valagussa P. Alternating drug combinations in the treatment of advanced Hodgkin’s disease. N. Engl. J. Med. 306: 770, 1982.

    Article  CAS  PubMed  Google Scholar 

  6. Belfiore A., Garofalo M.R., Giuffrida D., Runello F., Filetti S., Fiumara A., Ippolito O., Vigneri R. Increased aggressiveness of thyroid cancer in patients with Graves’ disease. J. Clin. Endocrinol. Metab. 70: 830, 1990.

    Article  CAS  PubMed  Google Scholar 

  7. Farbota L.M., Calandra D.B., Lawrence A.M., Paloyan E. Thyroid carcinoma in Graves’ disease. Surgery 98: 1148, 1985.

    CAS  PubMed  Google Scholar 

  8. Mazzaferri E.L. Thyroid cancer and Graves’ disease. J. Clin. Endocrinol. Metab. 70: 826, 1990.

    Article  CAS  PubMed  Google Scholar 

  9. Farid N.R., Shi Y., Zou M. Molecular basis of thyroid cancer. Endocr. Rev. 15: 202, 1994.

    CAS  PubMed  Google Scholar 

  10. Hales I.B., McElduff A., Crummer P., Clifton-Bligh P., Delbridge L., Hoschl R., Pole A., Reeve T.S., Wilmshurst E., Wiseman J. Does Graves’ disease or thyrotoxicosis affect the prognosis of thyroid cancer. J. Clin. Endocrinol. Metab. 75: 886, 1992.

    CAS  PubMed  Google Scholar 

  11. Filetti S., Belfiore A., Amir S.M., Daniels G.H., Ippolito O., Vigneri R., Ingbar S. The role of thyroid-stimulating antibodies of Graves’ disease in differentiated thyroid cancer. N. Engl. J. Med. 318: 753, 1988.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Belfiore, A., Pellegriti, G., Milone, G. et al. Early occurrence of a thyroid carcinoma in a patient who developed Graves’ disease after treatment for Hodgkin’s disease. J Endocrinol Invest 18, 869–871 (1995). https://doi.org/10.1007/BF03349835

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03349835

Key-words

Navigation