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Liddle’s syndrome: Heritable human hypertension caused by mutations in the ß subnit of the epithelial sodium channel

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References

  1. Liddle G.W., Bledsoe T., Coppage W.S. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans. Assoc. Am. Physicians 76: 199, 1963.

    CAS  Google Scholar 

  2. Botero-Velez M., Curtis J.J., Warnock D.G. Liddle’s syndrome revisited — A disorder of sodium reabsorption in the distal tubule. New. Engl. J. Med. 330: 178, 1994.

    Article  CAS  PubMed  Google Scholar 

  3. Canessa C.M., Schild L., Buell G., Thorens B., Gantschi I., Horisberger J.D., Rossier B. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 367: 463, 1994.

    Article  CAS  PubMed  Google Scholar 

  4. Shimkets R.A., Warnock D.G., Bositis C.M., Nelson-Williams C., Hansson J.H., Schambelan M., Gill J.R., Ulick S., Milora R.V., Findling J.W., Canessa C., Rossier B.C., Lifton R.P. Liddle’s syndrome: Heritable human hypertension caused by mutations in the ß subunit of the epithelial sodium channel. Cell. 79: 407, 1994.

    Article  CAS  PubMed  Google Scholar 

  5. Schild L., Canessa C.M., Shimkets R.A., Gautsch I., Lifton R.P., Rossier B.C. A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in xenopus laevis oocyte expression system. Proc. Natl. Acad. Sci. USA 92: 5699, 1995.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Lifton R.P., Dluhy R.G., Powers M., Rich G.M., Cook S., Ulick S., Lalouel J.M. A chimaeric 11ß-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355: 262, 1992.

    Article  CAS  PubMed  Google Scholar 

  7. Volpe M., Lembo G., De Luca M., Lamenza F., Tritto C., Ricciaderli B., Molaro M., De Campera P., Condorelli G., Rendina V., Trimarco B., Condorelli M. Abnormal hormonal and renal responses to saline load in hypertensive patients with parental history of cardiovascular accidents. Circulation. 84: 92, 1991.

    Article  CAS  PubMed  Google Scholar 

  8. Nabika T., Bonnardeaux A., James M., Julier C., Jeunemaitre X., Corvol P., Lathrop M., Soubrier F. Evaluation of the SA locus in human hypertension. Hypertension 25: 6, 1995.

    Article  CAS  PubMed  Google Scholar 

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Shimkets, R.A., Warnock, D.G., Bositis, C.M. et al. Liddle’s syndrome: Heritable human hypertension caused by mutations in the ß subnit of the epithelial sodium channel. J Endocrinol Invest 18, 592–594 (1995). https://doi.org/10.1007/BF03349775

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