Skip to main content
SpringerLink
Log in

The mineralocorticoid receptor discriminates aldosterone from glucocorticoids independently of the 11ß-hydroxysteroid dehydrogenase

  • Journal Club
  • Recently published papers, considered to be of high relevance, commented upon by invited discussants
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Funder J.W. Enzymes and receptors: challenges and future directions. Steroid 59: 164, 1994.

    Article  CAS  Google Scholar 

  2. Rafestin-Oblin M.E., Lombes M., Couette B., Baulieu E.E. Differences between aldosterone and its antagonists in binding kinetics and ligand-induced hsp90 release from mineralocorticosteroid receptor. J. Steroid. Biochem. Molec. Biol. 41: 815, 1992.

    Article  CAS  PubMed  Google Scholar 

  3. Arriza J.L., Weinberger C., Cerelli G., Glaser T.M., Handelin B.L., Housman D.E., Evans R.M. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237: 268, 1987.

    Article  CAS  PubMed  Google Scholar 

  4. Rupprecht R., Arriza J.L., Spengler D., Reul J.M.H.M., Evans R.M., Holsboer F., Dammn K. Trans-activation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor. Mol. Endocrinol. 7: 597, 1993.

    CAS  PubMed  Google Scholar 

  5. Arriza J.L., Simerly R.B. Swanson L.W., Evans R.M. The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron 1: 887, 1988.

    Article  CAS  PubMed  Google Scholar 

  6. Cato A.C.B., Mink S., Harting E. Gene activation mediated by glucocorticoid and mineralocorticoid receptors: the role of the steroid ligand. In: Bonvalet J.P., Farman N., Lombes M., Rafestin-Oblim M.E. (Eds.), Aldosterone: Fundamental Aspects. Colloque INSERM/Libbey Eurotext, Paris, London, 1991, vol. 215, p. 23.

    Google Scholar 

  7. Pearce D., Yamamoto K.R. Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259: 1661, 1993.

    Article  Google Scholar 

  8. Funder J.W., Sheppard K. Adrenocortical steroids and the brain. In: Berne R.M., Hoffman J.F., MacKichan M.L. (Eds.), Annual Review of Physiology. Annual Reviews. Inc., Palo. Alto., Vol. 49, p. 397.

  9. Albiston A., Obeyesekere V., Smith R., Krozowski Z.S. Cloning and tissue distribution of the human 11-beta hydroxysteroid dehydrogenase type II enzyme. Mol. Cell. Endocrinol. 105: R11, 1994.

    Article  CAS  PubMed  Google Scholar 

  10. Lifton R.P., Dluky R.G., Powers M., Rich G.M., Cook S., Lalouel J.-M. A chimaeric 11ß-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355: 262, 1992.

    Article  CAS  PubMed  Google Scholar 

  11. Shimkets R.A., Warnock D.G., Bositis C.M., Nelson-Williams C., Hansson J.H., Schambelan M., Gill J.R., Ulick S., Milora R.U., Findling J.W., Canessa C.M., Rossier B.C., Lifton R.P. Liddle’s syndrome: heritable human hypertension caused by mutations in the ß subunit of the epithelial sodium channel. Cell 79: 407, 1994.

    Article  CAS  PubMed  Google Scholar 

  12. Kwak S.P., Patel P.D., Thompson R.C., Akil H., Watson S.J. 5′-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus. Endocrinology 133, 2344, 1993.

    CAS  PubMed  Google Scholar 

  13. Conneely O.M., Kettelberger D.M., Tsai M.-J., Schrader W.T., O’Malley B.W. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J. Biol. Chem. 264: 14062, 1989.

    CAS  PubMed  Google Scholar 

  14. Zelent A., Mendelsohn C., Kastner P., Krust A., Gamier J-M., Ruffenach F., Leroy P., Chambon P. Differentially expressed isoforms of the mouse retinoic acid receptor b are generated by usage of two promoters and alternative splicing. EMBO J. 10: 71, 1991.

    CAS  PubMed Central  PubMed  Google Scholar 

  15. Komesaroff P.A. Verity K., Fuller P.J. Pseudohypoaldosteronism: molecular characterisation of the mineralocorticoid receptor. J. Clin. Endocrinol. Metab. 79: 27, 1994.

    CAS  PubMed  Google Scholar 

  16. Zennaro M.C., Borensztein P., Jeunemaitre X., Armanini D., Soubrier F. No alteration in the primary structure of the mineralocorticoid receptor in a family with pseudohypoaldosteronism. J. Clin. Endocrinol. Metab. 79: 32, 1994.

    CAS  PubMed  Google Scholar 

  17. Arai K., Tsigos C., Suzuki Y., Listwak S., Zachman K., Zangeneh F., Rapaport R., Chanoine J.P., Chrousos G.P. No apparent mineralocorticoid receptor defect in a series of sporadic cases of pseudohypoaldosteronism. J. Clin. Endocrinol. Metab. 80: 814, 1995.

    CAS  PubMed  Google Scholar 

  18. Kuhnle U., Keller U., Armanini D., Funder J., Krozowski Z. Immunofluorescence of mineralocorticoid receptors in peripheral lymphocytes: presence of receptor-like activity in patients with the autosomal dominant form of pseudohypoaldosteronism, and its absence in the recessive form. J. Steroid Biochem. Mol. Biol. 51: 267, 1995.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM U 246, UER Xavier Bichat, Paris, France

    M. Lombes, S. Kenouch, A. Souque, N. Farman & M. E. Rafestin-Oblin

  2. Baker Medical Research Institute, Prahran, Victoria, Australia, 3181

    John W. Funder

Authors
  1. M. Lombes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Kenouch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Souque
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Farman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. E. Rafestin-Oblin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. John W. Funder
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lombes, M., Kenouch, S., Souque, A. et al. The mineralocorticoid receptor discriminates aldosterone from glucocorticoids independently of the 11ß-hydroxysteroid dehydrogenase. J Endocrinol Invest 18, 576–579 (1995). https://doi.org/10.1007/BF03349770

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03349770

Keywords

Search

Navigation