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Vascular remodeling and mineralocorticoids

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Abstract

Circulating mineralocorticoid hormones are so named because of their important homeostatic properties that regulate salt and water balance via their action on epithelial cells. A broader range of functions in nonclassic target cellular sites has been proposed for these steroids and includes their contribution to wound healing following injury. A chronic, inappropriate (relative to intravascular volume and dietary sodium intake) elevation of these circulating hormones evokes a wound healing response in the absence of tissue injury — a wound healing response gone awry. The adverse remodeling of vascularized tissues seen in association with chronic mineralocorticoid excess is the focus of this review.

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Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine and Dalton Cardiovascular Research Center, University of Missouri Health Sciences Center, USA

    Karl T. Weber M.D., Y. Sun, S. E. Campbell, S. H. Slight & V. K. Ganjam

  2. College of Veterinary Medicine, Columbia, Missouri, USA

    V. K. Ganjam

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  1. Karl T. Weber M.D.
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  2. Y. Sun
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  3. S. E. Campbell
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  4. S. H. Slight
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  5. V. K. Ganjam
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Weber, K.T., Sun, Y., Campbell, S.E. et al. Vascular remodeling and mineralocorticoids. J Endocrinol Invest 18, 533–539 (1995). https://doi.org/10.1007/BF03349764

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