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Positive control of proliferation by the cyclic AMP cascade: An oncogenic mechnism of hyper-functional adenoma

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References

  1. Dumont J.E., Lamy F., Roger P., Maenhaut C. Physiological and pahtological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiological Reviews 72(3): 667, 1992.

    PubMed  CAS  Google Scholar 

  2. Pohl V., Maenhaut C, Gerard C., Vassart G., Dumont J.E. Differential regulation of thyrotropin receptor and thyroglobulin mRNA accumulation at the cellular level: an in situ hybridization study. Experimental Cell Research 199: 392, 1992.

    Article  PubMed  CAS  Google Scholar 

  3. Laurent E., Van Sande J., Ludgate M., Corvilain B., Rocmans P., Dumont J.E., Mockel J. Unlike thryotropin, thyroid-stimulating antibodies do not activate phospholipase C in human thyroid slices. J. Clin. Invest. 87: 1634, 1991.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  4. Dumont A., Jauniaux J.C., Roger P.P. The cyclic AMP-mediated stimulation of cell proliferation. Trends in Biochem. Sci. 14(2): 67, 1989.

    Article  CAS  Google Scholar 

  5. Maenahut C., Roger P.P., Reuse S., Dumont J.E. Activation of the cyclic AMP cascade as an oncogenic mechanism: the thyroid example. Biochimie 73: 29, 1991.

    Article  Google Scholar 

  6. Libert F., Lefort A., Gerard C., Parmentier M., Perret J., Ludgate M., Dumont J.E., Vassart G. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 165: 1250, 1989.

    Article  PubMed  CAS  Google Scholar 

  7. Maenhaut C, Van Sande J., Libert F., Abramowicz M., Parmentier M., Vanderhaeghen J.J., Dumont J.E., Vassart G., Schiffmann S. RDC8 codes for an adenosine A2 receptor with physiologivca constitutive activity. Biochem. Biophys. Res. Commun. 173: 1169, 1990.

    Article  PubMed  CAS  Google Scholar 

  8. Ledent C., Parmentier M., Vassart G. Tissue-specific expression and methylation of a thyroglobulin-CAT fusion gene in transgenic mice. Proc. Natl. Acad. Sci. USA 87: 6176, 1990.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  9. Ledent C., Dumont J.E., Vassart G., Dumont J.E. Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism. The EMBO Journal 11(2): 537, 1992.

    PubMed Central  PubMed  CAS  Google Scholar 

  10. Libert F., Van Sande J., Lefort A., Czernilofsky A., Dumont J.E., Vassart G., Ensinger H.A., Mendia K.D Cloning and functinal characterizatin of a human A1 adenosine receptor. Biochem. Biophys. Res. Commun. 187(2): 919, 1992.

    Article  CAS  Google Scholar 

  11. Nagayama Y., Rapoport B. The thyrotropin receptor 25 years after its discovery: new insight after its molecular cloning. Mol. Endocrinol. 6: 145, 1992.

    PubMed  CAS  Google Scholar 

  12. Kosugi S., Okajima F., Ban T., Hidaka A., Shenker A., Kohn L.D. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3’, 5’-cyclic adenosine monophosphate signal generation. Mol. Endo. 7(8): 1009, 1993.

    CAS  Google Scholar 

  13. Parma J., Duprez L., Van Sande J., Cochaux P., Gervy C, Mockel J., Dumont J.E., Vassrt G. Somatic mutations in the thyrotropin receptor gene are responsible for hyperfunctioning thyroid adenomas. Nature 365: 649, 1993.

    Article  PubMed  CAS  Google Scholar 

  14. Van Sande J., Lamy F., Lecocq R., Mirkine N., Rocmans P., Cochaux P., Mockel J., Dumont J.E. Pathogenesis of autonomous thyroid nodules: In vitro study of iodine and adenosine 3’, 5’-monophosphate metabolism. J. Clin. Endocrinol. Metab. 66(3): 570, 1988.

    Article  PubMed  Google Scholar 

  15. Reuse S., Maenhaut C., Dumont J.E. Regulation of protooncogenes c-fos and c-myc expressions by protein tyrosine kinase, protein kinase C, and cyclic AMP mitogenic pathways in dog primary thyrocytes: a postivie and negative control by cyclic AMP on c-myc expression. Experimental Cell Research 189: 33, 1990.

    Article  PubMed  CAS  Google Scholar 

  16. Reuse S., Maenhaut C., Lefort A., Libert F., Parmentier M., Raspe E., Roger P., Corvilain B., Laurent E., Mockel J., Lamy F., Van Sande J., Dumont J.E. The Control of Human Thyroid Cell Function. Proliferation and Differentiation. NATO ASI Series, vol. H. 44. Eds T.M. Konijn, M.D. Houslay, P.J.M. Van Haastert. Springer Verlag Berlin, Heidelberg 1990.

    Google Scholar 

  17. Reuse S., Pirson I., Pohl V., Maenhaut C., Roger P., Dumont J.E. The cyclic AMP cascade as a trigger or stimulant of epithelial cell proliferation: the example of the thyroid. Excerpta Medical international Congress Series 925: Growth Factors in Health and Disease-Basic and Clinical Aspects (Westermark B., Betsholtz C, Hakfeit B.) Elsevier 199, 1990.

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Ledent, C., Parma, J., Pirson, I. et al. Positive control of proliferation by the cyclic AMP cascade: An oncogenic mechnism of hyper-functional adenoma. J Endocrinol Invest 18, 120–122 (1995). https://doi.org/10.1007/BF03349717

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