Journal of Endocrinological Investigation

, Volume 13, Issue 11, pp 937–941 | Cite as

Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil

  • C. Y. Hayashida
  • A. J. S. Duarte
  • A. E. Sato
  • E. H. Yamashiro-Kanashiro
Case Report


A female newborn whose mother was taking propylthiouracil (PTU) for Graves’ disease, presented with transient thyrotoxicosis (serum triiodothyronine 1,710 ng/dl) and signs of acute hepatic injury. Jaundice and choluria were evident on her fourth day of life. Serum total bilirubin reached 14 mg/dl, with a direct fraction of 11 mg/dl. Serum alanine aminotransferase and aspartate aminotransferase showed moderate elevations (110 IU/I and 61.5 IU/I, respectively), as well as the alkaline prosphatase which increased to about twice the upper limit of normal. When incubated with PTU, the patient’s cultured peripheral lymphocytes underwent transformation to more than twice the values found in 2 controls, with a stimulation index (SI) of 3.19, compared to SI of 1.45 and 1.15 for the controls, suggesting a hypersensitivity mechanism involved in the hepatic injury. Although about 20 cases of PTU induced hepatic damage were reported in the medical literature, this is, as far as we know, the first description of neonatal liver injury probably caused by placental transfer of this drug.


Propylthiouracil hepatitis maternal-fetal exchange lymphocyte transformation 


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Copyright information

© Italian Society of Endocrinology (SIE) 1990

Authors and Affiliations

  • C. Y. Hayashida
    • 1
  • A. J. S. Duarte
    • 2
  • A. E. Sato
    • 3
  • E. H. Yamashiro-Kanashiro
    • 2
  1. 1.Department of Medicine, Division of EndocrinologySchool of Medicine, São Paulo UniversitySão PauloBrasil
  2. 2.Immunogenetics and Experimental Transplantation LaboratorySchool of Medicine, São Paulo UniversityBrasil
  3. 3.Unit of NeonatologyHospital e Maternidade Leonor Mendes de BarrosSão PauloBrasil

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