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Nocturnal oscillations of plasma aldosterone in relation to sleep stages

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Abstract

This study examined the relationship between aldosterone secretion and sleep stages in conjunction with two aldosterone regulating hormone systems, the renin-angiotensin system (RAS) and adrenocorticotropin (ACTH), and also K+. Nocturnal plasma patterns of aldosterone, plasma renin activity (PRA), ACTH and K+ were established in blood collected at 10-min intervals in two groups of 6 subjects. Both groups underwent two 9 hour overnight-studies, consisting of one control night and one experimental night. The first group was maintained on a low Na diet and the other was given a beta-blocker, atenolol. Polygraphic recordings of sleep were scored according to established criteria. For the control night, REM sleep usually began at peak level or in the descending phase of aldosterone oscillations. As previously described, PRA reflected REM-NREM sleep alteration, levels increased in NREM and decreased during REM sleep. ACTH fluctuations did not oscillate with sleep stages, but levels were very seldom in the ascending phase at REM sleep onset. Plasma K+ remained almost constant throughout the night. The relative importance of the ACTH and the RAS on nocturnal aldosterone secretion and the relationship between aldosterone oscillations and sleep stages remained unclear. Modulating renin levels by either consuming a low Na diet or administration of a beta-blocker enabled this relationship to be clarified. The RAS dominated aldosterone secretion when stimulated by a low sodium diet. Aldosterone oscillations then reflected PRA oscillations with a delay of about 20 min and the relationship of aldosterone to sleep stages was dependent on the relationship of PRA with sleep stages. Atenolol depressed PRA and in this case aldosterone levels reflected those of ACTH with a delay of about 10 min. To conclude, this study shows that the nocturnal secretion of aldosterone is under control of both the RAS and ACTH. Stimulating and depressing the RAS revealed that the relationship of aldosterone to sleep stages is dependent on the relationship of these hormonal systems to sleep stages.

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Authors and Affiliations

  1. Laboratoire de Physiologie et de Psychologie Environnementales CNRS/INRS UMR 32, 21 rue Becquerel, 67087, Strasbourg Cedex, France

    M. O. Krauth, J. Saini, M. Follenius &  G. Brandenberger

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  1. M. O. Krauth
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  2. J. Saini
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  3. M. Follenius
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  4. G. Brandenberger
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Krauth, M.O., Saini, J., Follenius, M. et al. Nocturnal oscillations of plasma aldosterone in relation to sleep stages. J Endocrinol Invest 13, 727–735 (1990). https://doi.org/10.1007/BF03349609

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  • DOI: https://doi.org/10.1007/BF03349609

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