Abstract
Estrogen deficiency is thought to be the main factor leading to postmenopausal osteoporosis (PMO). A role for calcitonin (CT) has been proposed as mediator of estrogen action on bone, and therefore, as pathogenetic factor of PMO. However, this hypothesis is still controversial. To further analyze the relationships between estrogens and CT in PMO, we studied the effects of one-year estro/progesterone therapy on CT secretory reserve, evaluated by a calcium infusion test in 12 postmenopausal women, as compared to 12 placebo treated subjects. In the hormone treated group, blood levels of CT showed a progressive increase during the study and a plateau was reached at 9 months, indicating that CT production achieved a new steady state. Hormonal therapy also significantly improved the CT response to calcium stimulation test. A concomitant increase of vertebral bone mass was observed in the hormone treated women, who also maintained initial bone density of femoral dyaphyses. On the contrary, the placebo treated group continued to lose bone mineral at both sites. Our study demonstrates that estrogens regulate CT secretion in postmenopausal women; thus, CT may be considered a mediator of estrogen action on bone.
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Caniggia A., Gennari C., Borrello G., Bencini M., Cesari L., Poggi C., Escobar C. Intestinal absorption of calcium-47 after treatment with oral oestrogen-gestogens in senile osteoporosis. Br. Med. J. 4:30, 1970.
Gallagher J.C., Riggs B.L, de Luca H.F. Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J. Clin. Endocrinol. Metab. 51: 1359, 1980.
Gennari C. Intestinal calcium absorption in postmenopausal osteoporosis. Bibl. Nutr. Dieta 33: 100, 1983.
Riggs B.L., Melton L.J. Evidence of two distinct syndromes of involutional osteoporosis. Am. J. Med. 75: 899, 1983.
Genant H.K., Cann E.C., Ettinger B., Gordon C.S. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann. Intern. Med. 97: 699, 1982.
Aitken J.M., Hart D.M., Anderson J.B., Lindsay R., Smith D.A., Speirs C.F. Osteoporosis after oophorectomy for non-malignant disease in premenopausal women. Br. Med. J. 11: 325, 1973.
Lindsay R., Hart D.M., Forrest C., Baird C. Prevention of spinal osteoporosis in oophorecto-mized women. Lancet 2: 1151, 1980.
Christiansen C., Christensen M.S., McNair P., Hagen C., Stocklund K.E., Transbol O. Prevention of early postmenopausal bone loss: controlled two years study in 315 normal females. Eur. J. Clin. Invest. 10: 273, 1980.
Lindsay R., Hart D.M., Aitken J.M., MacDonald E.B., Anderson J.B., Clark A.C. Long-term prevention of postmenopausal osteoporosis by estrogen. Evidence for an increased bone mass after delayed onset of estrogen treatment. Lancet 1: 1038, 1976.
Cristiansen C., Christensen M.S., Transbol I. Bone mass in postmenopausal women after withdrawal of estrogen-gestagen replacement therapy. Lancet 1: 459, 1981.
Ettinger B., Genant H.K., Cann C.E. Postmenopausal bone loss is prevented by treatment with low-dosage estrogens with calcium. Ann. Intern. Med. 106: 40, 1987.
Horsman A., Nordin B.E.C., Crilly R.G. Effects on bone of withdrawal of estrogen therapy. Lancet 2: 33, 1979.
Ericksen E.F., Colvard D.S., Berg N.J., Graham M.L., Mann K.G., Spelsberg T.C., Riggs B.L. Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241: 81, 1988.
Kamm B.S., Terpening C.M., Benz D.J., Graeme K.A., Gallegos A., Korc M., Greene G.L., O’Malley B.W., Haussier M.R. Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 241: 84, 1988.
Heath H. Ill, Sizemore G. Plasma calcitonin in normal man. J. Clin. Invest. 60: 1135, 1977.
Hillyard C.J., Maclntyre I., Stevenson J.C Relative deficiency of plasma calcitonin in normal women. Lancet 1: 961, 1978.
Deftos L.J., Weisman M.H., Williams J.W., Karpf D.B., Frumar A.M., Davidson B.J., Parthemore J.G., Judd H.L Influence of age and sex on plasma calcitonin in human beings. N. Engl. J. Med. 302: 1351, 1980.
Chesnut C.H., Baylink D.J., Sisom K., Nelp W.B., Roos B.A. Basal plasma immunoreactive calcitonin in postmenopausal osteoporosis. Metabolism 29: 559, 1980.
Milhaud G., Benezech-Lefevre M., Moukhtar M.S. Deficiency of calcitonin in age-related osteoporoses. Biomedicine 29: 272, 1978.
Whitehead M.I., Lance B., Horsman J., Myers C.H., Stevenson J.C. Effect of castration on calcium regulating hormones. In: Christiansen C., Arnaud C.D., Nordin B.E.C., Parfitt A.M., Peck W.A., Riggs B.L. (Eds.), Osteoporosis 1. Dept. of Clinical Chemistry, Glostrup Hospital, Denmark, 1984, p. 331.
Isaia G.C., Mussetta M., Salamano G., Massobrio M., Gallo M., Catufa S., Merlini C., Molinatti G.M. Influenza degli estrogeni sulia secrezione della calcitonina. Giorn. Ital. Met. Min. Elettr. 2: 69, 1988.
Morimoto S., Tsuji M., Okada Y., Onishi T., Kumahara Y. The effect of estrogens on human calcitonin secretion after calcium infusion in elderly female subjects. Clin. Endocrinol. (Oxf.) 13: 135, 1980.
Stevenson J.C., Abeyasekera G., Hillyard C.J., Phang K.G., Maclntyre I., Campbell S., Young O., Townsend P.T., Whitehead M.I. Calcitonin and the calcium-regulating hormones in postmenopausal women: effect of estrogens. Lancet 1: 693, 1981.
Civitelli R., Agnusdei D., Nardi P., Zacchei F., Avioli L.V., Gennari C. Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption, and 25-hydroxyvitamin d-1 -alpha-hydroxylase reserve in postmenopausal osteoporosis. Calcif. Tissue Int. 42: 77, 1988.
Stepan J.J., Prest J., Broulik P., Pacowsky V. Serum osteocalcin levels and bone alkaline phosphatase isoenzyme after oophorectomy and in primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 64: 1079, 1987.
Leggate J., Farish E., Fletcher C.D., Mcintosh W., Hart D.M., Sommerville J.M. Calcitonin and postmenopausal osteoporosis. Clin. Endocrinol. (Oxf.) 20: 85, 1982.
Tiegs R.D., Body J.J., Wahner H.W., Barta J., Riggs B.L, Heath H. III. Calcitonin secretion in postmenopausal osteoporosis. N. Engl. J. Med. 372: 1097, 1985.
Lobo R.A., Roy S., Shoupe D., Endres D.B., Adams J.S., Rude R.K., Singer F.R. Estrogen and progestin effects on urinary calcium and calciotropic hormones in surgically induced postmenopausal women. Horm. Metab. Res. 17: 370, 1985.
Heynen G., Franchimont P. Human calcitonin radioimmunoassay in normal and pathological conditions. Eur.J. Clin. Invest. 4: 213, 1974.
Emmertsen K., Marqversen J., Jensen F.T., Hansen H.H. Radioimmunoassay of calcitonin in unextracted human serum: a sensitive method. Scand. J. Clin. Lab. Invest. 42: 539, 1982.
Zseli J., Szuzs J., Steczek K., Szathmari M., Kellinn E., Horvath C.S., Hollo G.M. Decreased calcitonin reserve in accelerated postmenopausal osteoporosis. Horm. Metab. Res. 17: 696, 1985.
Greenberg C., Kukreja S.C., Bowser E.N., Hargis G.H., Henderson W.J, Williams G.A. Effects of oestradiol and progesterone on calcitonin secretion. Endocrinology 118: 2594, 1986.
Selby P.L, Peacock M., Barkworth S.A., Brown W.B, Taylor G.A. Early effects of ethinyloestradiol and norethisterone treatment in postmenopausal women on bone resorption and calcium regulating hormones. Clin. Sci. 69: 265, 1985.
Hurley D.L., Tiegs R.D., Barta J., Laakso K., Heath H. III. Effects of oral contraceptive and estrogen administration on plasma calcitonin in pre-and postmenopausal women. J. Bone Miner. Res. 4: 89, 1989.
Tiegs R.D., Heath H. III. Effects of altered calcium intake on diurnal and calcium-stimulated plasma calcitonin in normal women. J. Bone Miner. Res. 4: 407, 1989.
Reginster J.Y., Deroisy R., Albert A., Denis D., Lecart M.P., Collette J., Franchimont P. Relationship between whole plasma calcitonin levels, calcitonin secretory capacity, and plasma levels of estrone in healthy women and postmenopausal osteoporotics. J. Clin. Invest. 83: 1073, 1989.
Gallagher J.C., Riggs B.L., Jerpbak C.M., Arnaud C.D. The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women. J. Lab. Clin. Med. 95: 373, 1980.
McDermott M.T, Kidd G.S., Blue P., Ghaed V., Hofeldt F.D. Reduced bone mineral content in totally thyroidectomized patients: possible effect of calcitonin deficiency. J. Clin. Endocrinol. Metab. 56: 936, 1983.
Hurley D.L., Tiegs R.D., Wahner H.W., Heath H. III. Axial and appendicular bone mineral density in patients with long-term deficiency or excess of calcitonin. N.Engl. J. Med. 377: 537, 1987.
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Agnusdei, D., Civitelli, R., Camporeale, A. et al. Calcitonin and estrogens. J Endocrinol Invest 13, 625–630 (1990). https://doi.org/10.1007/BF03349583
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DOI: https://doi.org/10.1007/BF03349583