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The mouse submaxillary gland: a model for the study of hormonally dependent growth factors

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References

  1. Barka T. Biologically active polypeptides in submandibular glands. J. Histochem. Cytochem. 28: 836, 1980.

    Article  PubMed  CAS  Google Scholar 

  2. Gresik E., Barka T. Immunocytochemical localization of epidermal growth factor in mouse submandibular gland. J. Histochem. Cytochem. 25: 1027, 1977.

    Article  PubMed  CAS  Google Scholar 

  3. Schwab M., Stockel K., Thoenen H. Immunocytochemical localization of nerve growth factor (NGF) in the submandibular gland of adult mice by light and electron microscopy. Cell Tissue Res. 169: 289, 1976.

    Article  PubMed  CAS  Google Scholar 

  4. Murphy R.A., Pantaziz J.J., Papastavros M. Epidermal growth factor and nerve growth factor in mouse saliva: A comparative study. Dev. Biol. 77: 356, 1979.

    Article  Google Scholar 

  5. Greene L.A., Shooter E.M., Varon S. Enzymatic activities of mouse nerve growth factor and its subunits. Proc. Natl. Acad. Sci. USA 60: 1383, 1968.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  6. Taylor J.M., Mitchell W.M., Cohen S. Characterization of the binding protein for epidermal growth factor. J. Biol. Chem. 249: 3198, 1974.

    PubMed  CAS  Google Scholar 

  7. Ishii D.N., Shooter E.M. Regulation of nerve growth factor synthesis in mouse submaxillary gland by testosterone. J. Neurochem. 25: 843, 1975.

    Article  PubMed  CAS  Google Scholar 

  8. Bynny R.L., Orth D.N., Cohen S., Doyne E.S. Epidermal growth factor: Effect of androgens and adrenergic agents. Endocrinology 95: 776, 1974.

    Article  Google Scholar 

  9. Walker P., Weichsel M.E. Jr., Fisher D.A., Guo S.M., Fisher D.A. Thyroxine increases nerve growth factor concentration in adult mouse brain. Science 204: 427, 1979.

    Article  PubMed  CAS  Google Scholar 

  10. Walker P., Weichsel M.E. Jr., Guo S.M., Fisher D.A., Fisher D.A. Radioimmunoassay for mouse nerve growth factor (NGF). Effects of thyroxine administration on tissue NGF levels. Brain Res. 186: 331, 1980.

    Article  PubMed  CAS  Google Scholar 

  11. Aloe L., Levi-Montalcini R. Comparative studies on testosterone and L-thyroxine effects on the synthesis of nerve growth factor in mouse submaxillary glands. Exp. Cell Res. 125: 15, 1980.

    Article  PubMed  CAS  Google Scholar 

  12. Walker P., Weichsel M.E. Jr., Hoath S.B., Poland R.E., Fisher D.A. Effects of thyroxine, testosterone and corticosterone on nerve growth factor (NGF) and epidermal growth factor (EGF) concentrations in female mouse submaxillary gland. Dissociation of NGF and EGF response. Endocrinology 109: 582, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Hoath S., Lakshamanan J., Walker P., Scott S., Fisher D.A. Thyroxine (T4) increases epidermal growth factor (EGF) concentration in neonatal mouse skin. 63rd Annual Meeting, the Endocrine Society, Cincinnati, Ohio, June 17–19, 1981 (Abstract).

    Google Scholar 

  14. Bynny R.L., Orth D.N., Cohen S. Radioimmunoassay of epidermal growth factor. Endocrinology 90: 1261, 1972.

    Article  Google Scholar 

  15. Greene L.A., Shooter E.M. The nerve growth factor: Biochemistry, synthesis and mechanism of action. Ann. Rev. Neurosci. 3: 353, 1980.

    Article  PubMed  CAS  Google Scholar 

  16. Varon S., Nomura J., Shooter E.M. Reversible dissociation of the mouse nerve growth factor protein into different subunits. Biochemistry 7: 1296, 1968.

    Article  PubMed  CAS  Google Scholar 

  17. Angeletti R.H., Bradshaw R.A., Wade R.D. Subunit structure and amino acid composition of mouse submaxillary gland nerve growth factor. Biochemistry 10: 463, 1971.

    Article  PubMed  CAS  Google Scholar 

  18. Berger E.A., Shooter E.M. Evidence for pro-β-nerve growth factor, a biosynthetic precursor to β-nerve growth factor. Proc. Natl. Acad. Sci. USA 74: 3647, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  19. Berger E.A., Shooter E.M. Biosynthesis of β-nerve growth factor in mouse maxillary glands. J. Biol. Chem. 253: 804, 1978.

    PubMed  CAS  Google Scholar 

  20. Harper G.P., Pearce F.L., Vernon C.A. Production of nerve growth factor by the mouse adrenal medulla. Nature 261: 251, 1976.

    Article  PubMed  CAS  Google Scholar 

  21. Murphy R.A., Singer R.H., Saide J.D., Pantazis N.J., Blanchard M.H., Byron K.S., Arnason B.G.W. Synthesis and secretion of a high molecular weight form of nerve growth factor by skeletal muscle cells in culture. Proc. Natl. Acad. Sci. USA 74: 4496, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  22. Murphy R.A., Pantazis N.J., Arnason B.G.W., Young M. Secretion of a nerve growth factor by mouse neuroblastoma cells in culture. Proc. Natl. Acad. Sci. USA 72: 1895, 1975.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  23. Murphy R.A., Oger J., Saide J.D., Blanchard M.H., Arnason B.G.W., Hogan C., Pantazis N.J., Young M. Secretion of nerve growth factor by central nervous system glioma cells in culture. J. Cell. Biol. 72: 769, 1977.

    Article  PubMed  CAS  Google Scholar 

  24. Longo A.M., Penhoet E.E. Nerve growth factor in rat glioma cells. Proc. Natl., Acad. Sci. USA 71: 2347, 1974.

    Article  CAS  Google Scholar 

  25. Lindsay R.M. Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurones. Nature 282: 80, 1979.

    Article  PubMed  CAS  Google Scholar 

  26. Norrgren G., Ebendal T., Belew M., Jacobsen C.O., Parath J. Release of nerve growth factor by human glial cells in culture. Exp. Cell. Res. 130: 31, 1980.

    Article  PubMed  CAS  Google Scholar 

  27. Oger J., Arnason B.G.W., Pantazis N., Lehrich J., Young M. Synthesis of nerve growth factor by L and 3T3 cells in culture. Proc. Natl. Acad. Sci. USA 71: 1554, 1974.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  28. Pantazis N.J., Blanchard M.H., Arnason B.G.W., Young M. Molecular properties of the nerve growth factor secreted by L cells. Proc. Natl. Acad. Sci. USA 74: 1492, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  29. Sherman S.A., Sliski A.H., Todaro G.J. Human melanoma cells have both nerve growth factor and nerve growth factor specific receptors on their cell surfaces. Proc. Natl. Acad. Sci. USA 76: 1288, 1979.

    Article  Google Scholar 

  30. Harper G.P., Al-Saffar A.M., Pearce F.L., Vernon C.A. The production of nerve growth factor in vitro by tissues of the mouse, rat, and embryonic chick. Dev. Biol. 77: 379, 1980.

    Article  PubMed  CAS  Google Scholar 

  31. Ebendal T., Olson L., Seiger A., Medlund K.O. Nerve growth factors in the rat iris. Nature 286: 25, 1980.

    Article  PubMed  CAS  Google Scholar 

  32. Goldstein L.D., Reynolds C.P., Perez-Polo J.R. Isolation of human nerve growth factor from placental tissue. Neurochemical Res. 3: 185, 1978.

    Article  Google Scholar 

  33. Walker P., Weichsel M.E. Jr., Fisher D.A. Human nerve growth factor: lack of immunocro-ssreactivity with mouse nerve growth factor. Life Sci. 26: 195, 1980.

    Article  PubMed  CAS  Google Scholar 

  34. Harper G.P., Thoenen H. The distribution of nerve growth factor in the male sex organs of mammals. J. Neurochem. 34: 893, 1980.

    Article  PubMed  CAS  Google Scholar 

  35. Carpenter G., Cohen S. Epidermal growth factor. Annu. Rev. Biochem. 48: 193, 1979.

    Article  PubMed  CAS  Google Scholar 

  36. Taylor J.M., Cohen S., Mitchell W.M. Epidermal growth factor: high and low molecular weight forms. Proc. Natl. Acad. Sci. USA 67: 64, 1970.

    Google Scholar 

  37. Savage C.R., Inagami T., Cohen S. The primary structure of epidermal growth factor. J. Biol. Chem. 247: 7612, 1972.

    PubMed  CAS  Google Scholar 

  38. Server A.C., Shooter E.M. A comparison of the arginine esteropeptidases associated with the nerve and epidermal growth factor. J. Biol. Chem. 25: 165, 1976.

    Google Scholar 

  39. Turkington R.W., Males J.L., Cohen S. Synthesis and storage of epithelial-epidermal growth factor in submaxillary gland. Cancer Res. 37: 252, 1971.

    Google Scholar 

  40. Frey P., Forand R., Maciag T., Shooter E.M. The biosynthesis precursor of epidermal growth factor and the mechanism of its processing. Proc. Natl. Acad. Sci. USA 76: 6294, 1979.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  41. Hirata Y., Orth D.N. Epidermal growth factor (Urogastrone) in human tissues. J. Clin. Endocrinol. Metab. 48: 667, 1979.

    Article  PubMed  CAS  Google Scholar 

  42. Hirata Y., Orth D.N. Epidermal growth factor (Urogastrone) in human finds: Size heterogeneity. J. Clin. Endocrinol. Metab. 48: 673, 1979.

    Article  PubMed  CAS  Google Scholar 

  43. Cohen S., Carpenter G. Human epidermal growth factor: isolation and chemical and biological properties. Proc. Natl. Acad. Sci. USA 72: 1317, 1975.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  44. Gregory H. Isolation and structure of urogastrone and its relationship to epidermal growth factor. Nature 257: 325, 1975.

    Article  PubMed  CAS  Google Scholar 

  45. Hollenberg M.D., Gregory H. Human urogastrone and mouse epidermal growth factor share a common receptor site in cultured human fibroblasts. Life Sci. 20: 267, 1977.

    Article  PubMed  CAS  Google Scholar 

  46. Elder J.B., Williams G., Lacey E., Gregory H. Cellular localization of human urogastrone epidermal growth factor. Nature 271: 466, 1978.

    Article  PubMed  CAS  Google Scholar 

  47. Walker P., Tarris R.H., Scott S.M., Fisher D.A. Nerve growth factor (NGF) in human cord serum: Demonstration of a veno-arterial gradient. J. Clin. Endocrinol Metab. 53: 218, 1981.

    Article  PubMed  CAS  Google Scholar 

  48. Levi-Montalcini R., Hamberger V. A diffusable agent of mouse sarcoma, producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo. J. Exp. Zool. 723: 233, 1953.

    Article  Google Scholar 

  49. Levi-Montalcini R. The nerve growth factor, its mode of action on sensory and sympathetic nerve cells. Harvey Lect. 60: 217, 1966.

    PubMed  CAS  Google Scholar 

  50. Bradshaw R.A. Nerve growth factor. Annu. Rev. Biochem. 47: 191, 1978.

    Article  PubMed  CAS  Google Scholar 

  51. Hendry I.A., Stöckel K., Thoenen H., Iversen L.L. The retrograde axonal transport of nerve growth factor. Brain Res. 68: 103, 1974.

    Article  PubMed  CAS  Google Scholar 

  52. Andres R.Y., Jeg I., Bradshaw R.A. Nerve growth factor receptors: Identification of distinct classes in plasma membranes and nuclei of embryonic dorsal root neurons. Proc. Natl. Acad. Sci. USA 74: 2785, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  53. Huff K., Lakshmanan J., Guroff G. RNA polymerase activity in the superior cervical ganglion of the neonatal rat: Effect of nerve growth factor. J. Neurochem. 31: 599, 1978.

    Article  PubMed  CAS  Google Scholar 

  54. MacDonnell P.C., Nagaiah K., Lakshmanan J., Guroff G. Nerve growth factor increases activity of ornithine decarboxylase in superior cervical ganglion of young rats. Proc. Natl. Acad. Sci. USA 74: 4681, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  55. Partlow L.M., Larrabee M.G. Effects of a nerve growth factor, embryo age and metabolic inhibitors on growth of fibers and on synthetic of ribonucleic acid and protein in embryonic symphatetic ganglia. J. Neurochem. 78: 2101, 1971.

    Article  Google Scholar 

  56. Thoenen H., Angeletti P.U., Levi-Montalcini R., Kettler R. Selection induction by nerve growth factor of tyrosine hydroxylase and dopamine β-hydroxylase in the rat cervical ganglia. Proc. Natl., Acad., Sci. USA 68: 1598, 1971.

    Article  CAS  Google Scholar 

  57. Levi-Montalcini R., Booker B. Destruction of the sympathetic ganglia in mammals by an antiserum to nerve growth factor. Proc. Natl. Acad. Sci. USA 46: 384, 1960.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  58. Gorin P.D., Johnson E.M. Jr. Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: an experimental autoimmune approach. Brain Res. 198: 27, 1980.

    Article  PubMed  CAS  Google Scholar 

  59. Bjerre B., Bjorklund A., Mobley W. A stimulatory effect by nerve growth factor on the regrowth of adrenergic nerve fibers in the mouse peripheral tissues after chemical sympathectomy with 6-hydroxydopamine. Z. Zelleforsch 146: 15, 1973.

    Article  CAS  Google Scholar 

  60. Bjerre B., Wiklund L., Edwards D.C. A study of the de- and regenerative changes in the sympathetic nervous system of the adult male mouse after treatment with antiserum to nerve growth factor. Brain Res. 92: 257, 1975.

    Article  PubMed  CAS  Google Scholar 

  61. Campenot R.D. Local control of neurite development by nerve growth factor. Proc. Natl. Acad. Sci. USA 74: 4516, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  62. Freed W.J. The role of nerve growth factor (NGF) in the central nervous system. Brain Res. Bull. 7: 393, 1976.

    Article  Google Scholar 

  63. Walker P., Weil M.L., Weichsel M.E. Jr., Fisher D.A. The role of NGF in brain maturation. In: Hetzel B.S., Smith R.M. (Eds.), Fetal brain disorders: Recent approaches to the problem of mental deficiency. Elsevier/North-Holland, Amsterdam, 1981, p. 187.

    Google Scholar 

  64. Frazier W.A., Boyd L.F., Szutowicz A., Pulliam M.W., Bradshaw R.A. Properties and specificity of binding sites for 125l-nerve growth factor in embryonic heart and brain. J. Biol. Chem. 249: 5918, 1974.

    PubMed  CAS  Google Scholar 

  65. Frazier W.A., Boyd L.F., Szutwicz A., Pulliam M.W., Bradshaw R.A. Specific binding sites for 125l-nerve growth factor in peripheral tissues and brain. Biochem. Biophys. Res. Commun. 57: 1096, 1974.

    Article  PubMed  CAS  Google Scholar 

  66. Szutowicz A., Frazier W.A., Bradshaw R.A. Subcellular localization of nerve growth factor receptors. Thirteen day old chick embryo brain. J. Biol. Chem. 251: 1516, 1976.

    PubMed  CAS  Google Scholar 

  67. Szutowicz A., Frazier W.A., Bradshaw R.A. Subcellular localization of nerve growth factor receptors. Developmental correlations in chick embryo brain. J. Biol. Chem. 257: 1524, 1976.

    Google Scholar 

  68. Nicholson J.L., Altman J. The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation. Brain Res. 44: 13, 1972.

    Article  PubMed  CAS  Google Scholar 

  69. Nicholson J.L., Altman J. The effects of early hypo- and hyperthyroidism on the development of the rat cerebellar cortex. II. Synaptoge-nesis in the molecular layer. Brain Res. 44: 25, 1972.

    Article  PubMed  CAS  Google Scholar 

  70. Bjorklund A., Stenevi U. Nerve growth factor: Stimulation of regenerative growth of central noradrenergic neurons. Science 175: 1251, 1972.

    Article  PubMed  CAS  Google Scholar 

  71. Bjerre B., Bjorklund A., Stenevi U. Inhibition of the regenerative growth of central noradrenergic neurons by intracerebrally administered anti-NGF serum. Brain Res. 74: 1, 1974.

    Article  PubMed  CAS  Google Scholar 

  72. Turner J.E., Glaze K.A. Regenerative repair in the severed optic nerve of the newt (Triturus vividescens): Effect of nerve growth factor. Exp. Neurol. 57: 687, 1977.

    Article  PubMed  CAS  Google Scholar 

  73. Glaze K.A., Turner J.E. Regenerative repair in the severed optic nerve of the newt (Triturus vividencens): Effect of nerve growth factor antiserum. Exp. Neurol. 58: 500, 1978.

    Article  PubMed  CAS  Google Scholar 

  74. Ebbot S., Hendry I.A. Retrograde transport of nerve growth factor in the rat central nervous system. Brain Res. 139: 160, 1978.

    Article  Google Scholar 

  75. Schwab M.E., Often U., Agid Y., Thoenen H. Nerve growth factor (NGF) in the rat CNA: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coerulus and substantia nigra. Brain Res. 168: 473, 1979.

    Article  PubMed  CAS  Google Scholar 

  76. Berger B.D., Wise C.D., Stein L. Nerve growth factor: Enhanced recovery of feeding after hypothalamic damage. Science 180: 506, 1973.

    Article  PubMed  CAS  Google Scholar 

  77. Hart T., Chaimas, N., Moore R.Y., Stein D.G. Effects of nerve growth factor on behavioral recovery following caudate nuclus lesions in rats. Brain Res. Bull. 3: 245, 1976.

    Article  Google Scholar 

  78. Perkins M.S., Margules D.L., Ward I.L. Nerve growth factor: Intense polydipsie of long duration produced by ventral diencephalic application. Brain Res. 767: 351, 1979.

    Article  Google Scholar 

  79. Levis M.E., Avrith D.B., Fitzsimons J.T. Short-latency drinking and increased Na appetite after intracerebral micro-injections of NGF in rats. Nature 279: 440, 1978.

    Google Scholar 

  80. Lewis M.E., Lakshamanan J., Nagaiak K., MacDonnell P.C., Guroff G. Nerve growth factor increases activity of ornithine decarboxylase activity in rat brain. Proc. Natl. Acad. Sci. USA 75: 1021, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  81. Avrith D.B., Lewis M.E., Fitzsimons J.T. Renin-like effects of NGF evaluated using renin-angiotensin antagonists. Nature 285: 248, 1980.

    Article  PubMed  CAS  Google Scholar 

  82. Guroff G., Montgomery P., Tolson N., Lewis M.E., End D. Induction of ornithine decarboxylase by renin-free nerve growth factor. Proc. Natl. Acad. Sci. USA 77: 4607, 1980.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  83. Nagaiah K., Ikeno T., Lakshmanan J., MacDonnell P., Guroff G. Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat. Proc. Natl. Acad. Sci. USA 75: 2512, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  84. Often U., Baumann J.B., Girard J. Stimulation of the pituitary-adrenocortical axis by nerve growth factor. Nature 282: 413, 1979.

    Article  Google Scholar 

  85. Often U., Goedert M., Baumann J.B., Girard J. Stimulation of the pituitary-adrenocortical axis and induction of tyrosine hydroxylase by nerve growth factor are not dependent on submaxillary gland isorenin. Brain Res. 217: 207, 1981.

    Article  Google Scholar 

  86. Konkol R.J., Mailman R.B., Bendeich E.G., Garrisson A.M., Meuller R.A., Breele G.H. Evaluation of the effects of nerve growth factor and antinerve growth factor on the development of central cate-cholamine-containing neurons. Brain Res. 144: 277, 1978.

    Article  PubMed  CAS  Google Scholar 

  87. Olson L., Ebendal T., Seiger A. NGF and anti-NGF: Evidence against effects on filter growth in locus coeruleus from cultures of perinatal CNS tissues. Developmental Neuroscience 2: 160, 1979.

    Article  PubMed  CAS  Google Scholar 

  88. Harper G.P., Thoenen H. Nerve growth factor: Biological significance, measurement, and distribution. J. Neurochem. 34: 5, 1980.

    Article  PubMed  CAS  Google Scholar 

  89. Greene L.A. A quantitative bioassay for nerve growth factor (EGF) activity employing a clonal pheochromacytoma cell line. Brain Res. 133: 350, 1977.

    Article  CAS  Google Scholar 

  90. Scott S.M., Tarris R., Eveleth D., Mansfield H., Weichsel M.E. Jr., Fisher D.A. Bioassay detection of mouse nerve growth factor (mNGF) in the brain of adult mice. J. Neurosci. Res. 6: 653, 1981.

    Article  PubMed  CAS  Google Scholar 

  91. Johnson D.G., Gorden P., Kopin I.J. A sensitive radioimmunoassay for 7S nerve growth factor antigens in serum and tissues. J. Neurochem. 18: 2355, 1971.

    Article  PubMed  CAS  Google Scholar 

  92. Hendry I.A. Developmental changes in tissue and plasma concentrations of the biologically active species of nerve growth factor in the mouse, by using a two-site radioimmunoassay. Biochem. J. 128: 1265, 1972.

    PubMed Central  PubMed  CAS  Google Scholar 

  93. Shine H.D., Perez-Polo J.R. 7S nerve growth factor protein in the golden hamster. J. Neurochem. 27: 1315, 1976.

    Article  PubMed  CAS  Google Scholar 

  94. Walker P., Weil M.L., Weichsel M.E. Jr., Fisher D.A. Effect of thyroxine on nerve growth factor concentration in neonatal mouse brain. Life Sci. 28: 1777, 1981.

    Article  PubMed  CAS  Google Scholar 

  95. Suda K., Barde Y.A., Thoenen H. Nerve growth factor in mouse and rat serum: Correlation between bioassay and radioimmunoassay determinations. Proc. Natl. Acad. Sci. USA 75: 4042, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  96. Benowitz L.I., Shashoua V.E. Immunoreactive sites for nerve growth factor (NGF) in the goldfish brain. Brain Res. 172: 561, 1979.

    Article  PubMed  CAS  Google Scholar 

  97. Varon S., Raiborn C.W. Jr., Burnham P.A. Implication of a nerve growth factor-life antigen in the support derived by ganglionic neuronsfrom their homologous glia in dissociated cultures. Neurobiology 4: 317, 1974.

    PubMed  CAS  Google Scholar 

  98. Varon S., Bunge R.P. Trophic mechanism in the peripheral nervous system. Am. Rev. Neurosci. 1: 327, 1978.

    Article  CAS  Google Scholar 

  99. Longo A.M. Synthesis of nerve growth factor in rat glioma cells. Proc. Natl. Acad. Sci. USA 71: 2347, 1978.

    Article  Google Scholar 

  100. Norrgren G., Ebendal T., Belew M., Jacobsen J.O. Porath J. Release of nerve growth factor by human glial cells in culture. Exp. Cell. Res. 130: 31, 1980.

    Article  PubMed  CAS  Google Scholar 

  101. Walker P., Weichsel M.E. Jr., Eveleth D., Fisher D.A. Ontogenesis of nerve growth factor (NGF) and epidermal growth factor (EGF) in mouse submaxillarygland. Pediatr. Res. 1981 (Submitted).

    Google Scholar 

  102. Lauder J.M. Effects of early hypo-and hyperthyroidism on development of rat cerebellar cortex. IV. The parallel fibers. Brain Res. 142: 25, 1978.

    Article  PubMed  CAS  Google Scholar 

  103. Angeletti P.U.; Levi-Montalcini R., Carmia F. Ultrastructural changes in sympathetic neurons of newborn and adult mice treated with nerve growth factor. J. Ultrastruct. Res. 36: 24, 1971.

    Article  PubMed  CAS  Google Scholar 

  104. Calissano P., Cozzari C. Interaction of nerve growth factor with the mouse brain neurotubule protein(s). Proc. Natl. Acad. Sci. USA 71: 2131, 1974.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  105. Yamada K.M., Spooner B.X., Wessells N.K. Axon growth: role of microfilaments and microtubules. Proc. Natl. Acad. Sci. USA 66: 1206, 1970.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  106. Fellous A., Francon J., Virion A., Nunez J. Microtubules and brain development. FEBS Lett. 57: 5, 1975.

    Article  PubMed  CAS  Google Scholar 

  107. Francon J., Fellous A., Lennon A.M., Nunez J. Is thyroxine a regulatory signal for neurotubule assembly during brain development? Nature 266: 188, 1977.

    Article  PubMed  CAS  Google Scholar 

  108. Lennon A.M., Francon J., Fellous A., Nunez J. Rat, mouse, and guinea pig brain development and microtubule assembly. J. Neurochem. 35: 804, 1980.

    Article  PubMed  CAS  Google Scholar 

  109. Weingarten M.D., Lockwood A.H., Kwo S.Y., Kirschner M.W. A protein factor essential for microtubule assembly. Proc. Natl. Acad. Sci. USA 72: 1858, 1975.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  110. Mareck A., Fellous A., Francon J., Nunez J. Changes in composition and activity of microtubule-associated proteins during brain development. Nature 284: 353, 1980.

    Article  PubMed  CAS  Google Scholar 

  111. Levi A., Cimono M., Mercanti D., Chen J.S., Calissano P. Interaction of nerve growth factor, with tubulin. Studies on binding and induced polymerization. Biochem. Biophys. Acta 399: 50, 1975.

    Article  PubMed  CAS  Google Scholar 

  112. Chen M.G., Chen J.S., Calissano P., Levi-Montalcini R. Nerve growth factor prevents vinblastine destructive effects on sympathetic ganglia in newborn mice. Proc. Natl. Acad. Sci. USA 74: 5559, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  113. Johnson E.M. Destruction of the sympathetic nervous system in neonatal rats and hamsters by vinblastine: Prevention by concomitant administration of nerve growth factor. Brain Res. 747: 105, 1978.

    Article  Google Scholar 

  114. Monaco G., Calissano P., Mercanti D. Effect of NGF on in vitro performed microtubules. Evidence for a protective action against vinblastine. Brain Res. 729:265, 1977.

    Article  Google Scholar 

  115. Johnson E.M., Macia R.A., Andres R.Y., Bradshaw R.A. The effects of drugs which destroy the sympathetic nervous system in the retrograde transport of nerve growth factor. Brain Res. 171: 461, 1979.

    Article  PubMed  CAS  Google Scholar 

  116. Cohen S. Isolation of a mouse submaxillary protein accelerating incisor eruption and eyelid opening in the newborn animal. J. Biol Chem. 237, 1555, 1962.

    PubMed  CAS  Google Scholar 

  117. Cohen S., Taylor J.M. Part I. Epidermal growth factor: chemical and biological characterization. Recent Prog. Horm. Res. 30: 533, 1974.

    PubMed  CAS  Google Scholar 

  118. Cohen S., Taylor J.M. Part II. Recent studies on the chemistry and biology of epidermal growth factor. Recent Prog. Horm. Res. 30: 55, 1974.

    Google Scholar 

  119. O’Keefe E., Hollenberg M.D., Cuatrecasas P. Epidermal growth factor: characteristics of specific binding in membranes from liver, placenta, and other target tissues. Arch. Biochem. Biophys. 164: 518, 1974.

    Article  PubMed  Google Scholar 

  120. Carpenter G., Cohen S. 125l-labeled human epidermal growth factor. J. Cell Biol. 71: 159, 1976.

    Article  PubMed  CAS  Google Scholar 

  121. Savion N., Vlodavsky I., Gospodarowicz D. Nuclear accumulation of epidermal growth factor in cultured bovine corneal endothelial and granulosa cells. J. Biol. Chem. 256: 1149, 1981.

    PubMed  CAS  Google Scholar 

  122. Aharonov A., Pruss R.M., Herschman H.R. Epidermal growth factor: relationship between receptor regulation and mitogenesis in 3T3 cells. J. Biol. Chem. 252: 3970, 1978.

    Google Scholar 

  123. Bower J.M., Gamble R., Gregory H., Gerring E.L., Wilshire I.R. The inhibition of gastric and secretion by epidermal growth factor. Experientia 31: 825, 1975.

    Article  PubMed  CAS  Google Scholar 

  124. Benveniste R., Speeg K.V. Jr., Carpenter G., Cohen S., Lindner J., Rabinowitz D. Epidermal growth factor stimulates secretion of human chorionic gonadotropin by cultured human choriocarcinoma cells. J. Clin. Endocrinol. Metab. 46: 169.

  125. Bahn R.S., Speeg K.V. Jr., Ascoli M., Rabin D. Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells. J. Clin. Endocrinol. Metab. 107: 2121, 1980.

    CAS  Google Scholar 

  126. Carpenter G., Poliner L., King L. Jr. Protein phosphorylation in human placenta. Stimulation by epidermal growth factor. Mol. Cell. Endocrinol. 18:189, 1980.

    Article  PubMed  CAS  Google Scholar 

  127. Gospodarowicz D. Epidermal and nerve growth factors in mammalian development. Ann. Rev. Physiol. 43: 251, 1981.

    Article  CAS  Google Scholar 

  128. Hamburg M., Mendoza L.A., Burkart J.F., Weil F. Thyroid-dependent process in the developing nervous system. In: Hamburg M., Garrinton E.J.W. (Eds.), Hormones in development. Appleton- Century Crofts, New York, 1971, p. 100.

    Google Scholar 

  129. Nexti E., Hollenberg M.D., Figueroa A., Pratt R.M. Detection of epidermal growth factor-urogastrone and its receptor fetal mouse development. Proc. Natl. Acad. Sci. USA 77: 2782, 1980.

    Article  Google Scholar 

  130. Gresik E.W. Postnatal developmental changes in submandibular glands of rats and mice. J. Histochem. Cytochem. 28: 860, 1980.

    Article  PubMed  CAS  Google Scholar 

  131. Murphy R.A., Watson A.Y., Metz J., Forssmann W.G. The mouse submandibular gland: An exocrine organ for growth factors. J. Histochem. Cytochem. 28: 890, 1980.

    Article  PubMed  CAS  Google Scholar 

  132. Forgue-Lafitte M.E., Laburthe M., Chamblier M.C., Moody A.J., Rosselin G. Demonstration of specific receptors for EGF-urogas-trone in isolated rat intestinal epithelial cells. FEBS Lett. 114: 243, 1980.

    Article  PubMed  CAS  Google Scholar 

  133. Feldman E.J., Aures D., Grossman M.I. Epidermal growth factor stimulates ornithine decarboxylase activity in the digestive tract of mouse. Proc. Soc. Exp. Biol. Med. 159: 400, 1978.

    Article  PubMed  CAS  Google Scholar 

  134. Takayanagi I. Effects of urogastrone on mechanical activities of the stomach and intestinal of guinea-pig. J. Pharm. Pharmacol. 32: 228, 1980.

    Article  PubMed  CAS  Google Scholar 

  135. Johnson L.R., Guthrie P.D. Stimulation of rat oxyntic gland mucosal growth by epidermal growth factor. Am. J. Physiol. 238: G45, 1980.

    PubMed  CAS  Google Scholar 

  136. Hirata Y., Orth D.N. Concentrations of epidermal growth factor, nerve growth factor, and submandibular gland renin in male and female mouse tissue and fluids. Endocrinology 105: 1382, 1979.

    Article  PubMed  CAS  Google Scholar 

  137. Barthe P.L., Bullock L.P., Mowszowicz I., Bardin C.W., Orth D.N. Submaxillary gland epidermal growth factor: A sensitive index of biologic androgen activity. Endocrinology 95: 1019, 1974.

    Article  PubMed  CAS  Google Scholar 

  138. Bullock L.P., Barthe P.L., Mowszowicz I., Orth D.N., Bardin C.W. The effect of progestine on submaxillary gland epidermal growth factor: Demonstration of androgenic, synandrogenic and antiandrogenic actions. Endocrinology 97: 189, 1975.

    Article  PubMed  CAS  Google Scholar 

  139. Furokawa S., Nishitani H., Hayashi K. Level of the nerve growth factor activity in the submaxillary glands of genetically dystrophic mouse. Biochem. Biophys. Res. Commun. 76: 1202, 1977.

    Article  Google Scholar 

  140. Murphy R.A., Pantazis N.J., Papastauros M., Anderson E. Epidermal growth factor in the submandibular gland and serum of mice with muscular dystrophy chemical properties in dilute gland extracts. Endocrinology 105: 716, 1979.

    Article  PubMed  CAS  Google Scholar 

  141. Aharonov A., Goodman R., Walker P., Weichsel M.E. Jr., Herschman H.R. Decreased nerve growth factor (NGF) concentration in submaxillary glands (SMG) and heart of dystrophic (dy/dy) mice. Proc. 7th International Meeting, International Society of Neurochemistry, Jerusalem, Israel, September 2–6, 1979 (Abstract).

    Google Scholar 

  142. Hanker J.S., Carson K.A., Yates P.E., Preece J.W., Doe D.A., Ambrose W.W., Coffey J.C. Jr. Cytochemical correlates of structural sexual dimorphism in glandular tissues of the mouse. Histochem. J. 68: 99, 1980.

    Article  CAS  Google Scholar 

  143. Raynaud J. The action of thyroid and adrenal glands on the submaxillary glands of mice. In: Screebny L.M., Meyer J. (Eds.), Salivary glands and their secretion. Pergamon, Oxford, 1964, p. 47.

    Chapter  Google Scholar 

  144. Kumegawa M., Takuma T., Takagi Y. Precocious induction of secretory granules by hormones in convoluted tubules of mouse submandibular glands. Am. J. Anat. 749: 111, 1977.

    Article  Google Scholar 

  145. Takuma T., Tanemura T., Hosoda S., Kumegawa M. Effects of thyroxine and 5 α-dihydroxytestosterone on the activities of various enzymes in the mouse submandibular gland. Biochem. Biophys. Acta 541: 143, 1978.

    Article  PubMed  CAS  Google Scholar 

  146. Gresik E.W., Schenkein I., Van Der Noen H., Barka T. Hormonal regulation of epidermal growth factor and protease in the submandibular gland of the adult mouse. Endocrinology 109: 924, 1981.

    Article  PubMed  CAS  Google Scholar 

  147. Wallace L.J., Partlow L.M. α-Adrenergic regulation of secretion of mouse saliva rich in nerve growth factor. Proc. Natl. Acad. Sci. USA 73: 4210, 1976.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  148. Murphy R.A., Saide J.D., Banchard M.H., Young M. Nerve growth factor in mouse serum and saliva: role of the submandibular gland. Proc. Natl. Acad. Sci. USA 74: 2230, 1977.

    Google Scholar 

  149. Hirata Y., Orth D.N. Secretion of epidermal growth factor, nerve growth factor, and reninlike enzymes by dispersed male mouse submandibular glands in vitro. Endocrinology 107: 92, 1980.

    Article  PubMed  CAS  Google Scholar 

  150. Henrdy L.A. Iversen LL Reduction in the concentration of nerve growth factor in mice after sialectomy and castration. Nature 243: 500, 1973.

    Article  Google Scholar 

  151. Suda K., Barde Y.A., Thoenen H. Nerve growth factor in mouse and rat serum: Correlation between bioassay and radioimmunoassay determinations. Proc. Natl. Acad. Sci. USA 75: 4042, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  152. Ronne H., Anundi H., Rask L., Peterson P.A. Nerve growth factor binds to serum cr-2-macroglobulin. Biochem. Biophys. Res. Commun. 87: 330, 1979.

    Article  PubMed  CAS  Google Scholar 

  153. Levi-Montalcini R., Angeletti P.U. Biologic aspects of the nerve growth factor. In: Wolstenholme G.E.W., O’Connor M. (Eds.), Ciba Foundation Symposium: Growth of the nervous system. J. and A. Churchill Ltd, London, 1968, p. 126.

    Google Scholar 

  154. Aloe L., Levi-Montalcini R. Enhanced differentiation of sexually dimorphic organs in L-thyroxine treated Tfm mice. Cell. Tissue Res. 205: 19, 1980.

    Article  PubMed  CAS  Google Scholar 

  155. Dunn J.F., Wilson J.D. Developmental study of androgen responsiveness in the submandibular gland of the mouse. Endocrinology 96: 1571, 1975.

    Article  PubMed  CAS  Google Scholar 

  156. Oppenheimer J.H. Thyroid hormone action at the cellular level. Science 203: 971, 1979.

    Article  PubMed  CAS  Google Scholar 

  157. Shapiro S., Percin C.J. Thyroid hormone induction of α-glucosidase dehydrogenase in rats of different ages. Endocrinology 7: 1075, 1966.

    Article  Google Scholar 

  158. Oppenheimer J.H., Silva E., Schwartz H.L., Surks M.I. Stimulation of hepatic mitochondrial α-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. I. Characteristics of the response with specific nuclear binding sites fully saturated. J. Clin. Invest. 59: 517, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  159. Coulombe P., Schwartz H.L., Oppenheimer J.H. Relationship between the accumulation of pituitary growth hormone and nuclear occupancy by triiodothyronine in the rat. J. Clin. Invest. 62: 1020, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  160. Samuels H.H., Shapiro L.E. Thyroid hormone stimulates de novo growth hormone synthesis in cultured GH cells: evidence for the accumulation of a rate limiting RNA species in the induction process. Proc. Natl. Acad. Sci. USA 73: 3369, 1976.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  161. Oppenheimer J.H., Schwartz H.L., Surks M.I. Tissues differences in the concentration of triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, spleen and testis. Endocrinology 95: 897, 1974.

    Article  PubMed  CAS  Google Scholar 

  162. Silva J.E., Larsen P.R. Contributions of plasma triiodothyronine and local thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver, and kidney of hypothyroid rats. J. Clin. Invest. 61: 1247, 1978.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  163. Tata J.R. The action of growth and developmental hormones. Biol. Rev. 55: 285, 1980.

    Article  PubMed  CAS  Google Scholar 

  164. Oppenheimer J.H., Coulombe P., Schwartz H.L., Gutfeld N.W. Nonlinear (amplified) relationship between nuclear occupancy by triiodothyronine and the appearance rate of hepatic alpha-glycerophosphate dehydrogenase and malic enzyme in the rat. J.Clin. Invest. 67: 987, z.

  165. Coulombe P., Ruel J., Dussault J.H. Analysis of 3,3′-3-triiodothyronine-binding capacity and tissue response in the liver of the neonatal rat. Endocrinology 105: 952, 1979.

    Article  PubMed  CAS  Google Scholar 

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  1. Unité de Recherche en Biologie du Développement, Le Centre Hospitalier de l’Université Laval, 2705, Boulevard Laurier, Ste-Foy, Québec, G1V 4G2, Canada

    P. Walker MD

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Supported in part by Grant No. MA-7430 from the Medical Research Council of Canada. P. Walker is a Scholar of the Conseil de la Recherche en Santé du Québec.

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Walker, P. The mouse submaxillary gland: a model for the study of hormonally dependent growth factors. J Endocrinol Invest 5, 183–196 (1982). https://doi.org/10.1007/BF03349477

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