Abstract
The concentration of serum thyroglobulin was measured in sera of subjects with various thyroid disorders, before and after the administration of tracer doses of 131I. The mean serum human thyroglobulin (hTg) concentration before administration of the isotope was 35.2 ng/ml±7.8 (SE) in 13 subjects and 36.3 ng/ml±7.9 (SE) 24 h after the administration of 131I. The data indicate that no significant release of thyroglobulin occurs 24 h after the administration of tracer doses of 131I. In 2 of the 3 subjects, however, in whom samples were obtained at 4 and 8 h after diagnostic administration of 131I, a modest rise in serum Tg levels was observed. Determinations of serum thyroglobulin levels within 24 h after the administration of a tracer dose of 131I are nevertheless valid providing one allows sufficient time to elapse for tracer decay.
References
Van Herle A.J., Uller R.P., Matthews N., Bown J. Radioimmunoassay for measurement of thyroglobulin in human serum. J. Clin. Invest. 52: 1320, 1973.
Glinoer D., Puttemans N., Van Herle A.J., Camus M., Ermans A.M. Sequential study of the impairment of thyroid function in the early states of subacute thyroiditis. Acta. Endocrinol. (Kbh.) 77: 26, 1974.
Izumi M., Larsen P.R. Correlation of sequential changes in serum thyroglobulin, triiodothyronine and thyroxine in patients with Graves’ disease and subacute thyroiditis. Metabolism 27: 449, 1978.
Uller R.P., Van Herle A.J. The effect of therapy on serum thyroglobulin levels in patients with Graves’ disease. J. Clin. Endocrinol. Metab. 46: 747, 1978.
Van Herle A.J., Uller R.P. Elevated serum thyroglobulin: a marker of metastases in differentiated thyroid carcinomas. J. Clin. Invest. 56: 272, 1975.
De Groot L.J., Koye K., Refetoff S., Van Herle A.J., Rochman H. Serum angens and antibodies in the diagnosis of thyroid cancer. J. Clin. Endocrinol. Metab. 45: 1220, 1978.
Van Herle A.J., Chopra I.J., Hershman J.M., Hornabrook R.N. Serum thyroglobulin in inhabitants of an endemic goiter region of New Guinea. J. Clin. Endocrinol. Metab. 43: 512, 1978.
Gardner D.F., Rothman J., Utiger R.D. Serum thyroglobulin in normal subjects and patients with hyperthyroidism due to Graves’ disease: effects of T3, iodine, 131I and antithyroid drugs. Clin. EndocriRoL (Oxf.) 11: 585, 1979.
Torrigiani G., Doniach D., Roitt I.M. Serum thyroglobulin levels in healthy subjects and patients with thyroid disease. J. Clin. Endocrinol. Metab. 29: 305, 1969.
Author information
Authors and Affiliations
Additional information
Supported by a grant of the NATO Senior Scientist Program and a grant from USPHS Ca-13477.
Doctoral research Fellow IRSIA Brussels.
This work was carried out under Euratom contract no. 230-BIOB.
Rights and permissions
About this article
Cite this article
Van Herle, A.J., Demeester-Mirkine, N., Van Heuverswyn, B. et al. The effect of 131I for diagnostic purposes on serum thyroglobulin (hTg) levels in subjects with thyroidal disorders. J Endocrinol Invest 4, 107–110 (1981). https://doi.org/10.1007/BF03349426
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03349426