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Effects of ketoprofen on the calciuric and uricosuric activities of calcitonin in man

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Abstract

The action of ketoprofen on the calciuric and uricosuric effects of porcine calcitonin in man is reported. The drug is capable of inhibiting both effects. This action is considered like an effect on CT receptors in the kidney or a competitive action on prostaglandin synthesis.

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References

  1. Ardaillou R., Vaugnat P., Milhaud G., Richet G. Effets de la thyrocalcitonine sur l’excrétion rénale des phosphates, du calcium et des ions H+ chez l’homme. Nephron 4: 298, 1967.

    Article  CAS  PubMed  Google Scholar 

  2. Bijvoet L.M., Van Der Sluys Veer J., Grever, H.M., Schellekens A.P.M. Influence of calcitonin on renal excretion of sodium and calcium. In: Talmage R.V., Munson P.L. (Eds.), Calcium, parathyroid hormone and the calcitonins. Excerpta Medica, Amsterdam, 1972, p. 284.

    Google Scholar 

  3. Haas H.G., Dambacher M.A., Guncaga J., Lauffenburger T. Renal effects of calcitonin and parathyroid extract in man. J. Clin. Invest. 50: 2689, 1971.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Langer B., Peytreman A., Rufener C., Jenny M. Effets comparés de l’administration d’une dose unique de calcitonine synthetique (de type humain et de type saumon) chez l’homme normal et les sujects atteints de maladie de Paget ou d’hypercalcémie. Schweiz. Med. Wochenschr. 101: 69, 1971.

    CAS  PubMed  Google Scholar 

  5. Luisetto G., Nogarin L., Grigolini L. Effetti plasmatici e renali délia calcitonina sut calcio, magnesio e fosforo nei soggetti normali ed affetti da osteopatia: studio délia quota ultrafiltrabile. In: Pecile A., De Bastiani G., Pietrogrande V., Sirtori C. (Eds.), Conferme e prospettive nell’uso délia calcitonina. Fondazione C. Erba, Milano, 1976, p. 39.

    Google Scholar 

  6. Robinson C.J., Martin T.J., Matthews E.W, MacIntyre I. Mode of action of thyrocalcitonin. J. Endocrinol. 39: 71, 1967.

    Article  CAS  PubMed  Google Scholar 

  7. Caniggia A., Gennari C. Fisiopatologia clínica del metabolismo fosfocalcico. Luigi Pozzi, Roma, 1976, p. 177.

    Google Scholar 

  8. Aldred J.P., Kleszynski R.R., Bastian J.W. Effects of acute administration of porcine and salmon calcitonin on urine electrolyte excretion in rat. Proc. Soc. Exp. Biol. Med. 48: 1175, 1970.

    Article  Google Scholar 

  9. Ardaillou R., Milhaud G., Rousselet F. Effet de la thyrocalcitonine sur l’excrétion rénale du sodium et du chlore chez l’homme normal. C. R. Acad. Sci. (Paris) 264: 3037, 1967.

    CAS  Google Scholar 

  10. Bijvoet L.M., Van Der Slujs Veer I., De Vries H.R., Van Koppen A.T.J. Natriuretic effect of calcitonin in man. N. Engl. J. Med. 284: 681, 1971.

    Article  CAS  PubMed  Google Scholar 

  11. Keeler R., Walker V., Copp D.H. Natriuretic and diuretic effects of salmon calcitonin in man. Can. J. Physiol. Pharmacol. 48: 838, 1970.

    Article  CAS  PubMed  Google Scholar 

  12. Ardaillou R., Fillastre J.P. Renal excretion of phosphate, calcium and sodium during and after a prolonged thyrocalcitonin infusion in man. Proc. Soc. Exp. Biol. Med. 131: 56, 1969.

    Article  CAS  PubMed  Google Scholar 

  13. Paillard F., Ardaillou R., Maledin H., Fillastre J.P., Prier S. Renal effects of salmon calcitonin in man. J. Lab. Clin. Med. 80: 200, 1972.

    CAS  PubMed  Google Scholar 

  14. Blahos J., Osten J., Mertl L., Kotas J., Gregor O., Reisenauer R. The uricosuric effect of calcitonin. Horm. Metab. Res. 7: 445, 1975.

    Article  CAS  PubMed  Google Scholar 

  15. Barnet D.B., Edwards I.R., Smith A.S. Antagonism by indomethacin of diuretic response to calcitonin in man. Br. Med. J. 3: 686, 1975.

    Article  Google Scholar 

  16. Owen J.L., Ehrhart I.C., Weidner W.J., Scott J.B., Haddy F.J. Effects of indomethacin on local blood flow regulation in canine heart and kidney. Proc. Soc. Exp. Biol. Med. 149: 871, 1975.

    Article  CAS  PubMed  Google Scholar 

  17. Lee J.B. Cardiovascular-renal effects of prostaglandins. Arch. Intern. Med. 133: 56, 1974.

    Article  CAS  PubMed  Google Scholar 

  18. Guyonnet J.C., Fontaine P. Activité inhibitrice du 19.583 R.P. Kétoproféne vis à-vis de la synthèse des prostaglandines dans la préparation du poumon isolé de cobaye. Doc. Soc. Us. Chim. Rhône-Poulene. Note D.S. 53502, 1974.

    Google Scholar 

  19. Nordin B.E.C., Peacock M. Role of kidney in regulation of plasma calcium. Lancet 2: 1280, 1969.

    Article  CAS  PubMed  Google Scholar 

  20. Ardaillou R. Kidney and calcitonins. Nephron 15: 250, 1975.

    Article  CAS  PubMed  Google Scholar 

  21. Marx S.J., Woodard C.J., Aurbach G.D. Calcitonin receptors in kidney and bone. Science 178: 999, 1972.

    Article  CAS  PubMed  Google Scholar 

  22. Sraer J., Ardaillou R. Renal receptors of salmon calcitonin. In: Taylor S. (Ed.), Endocrinology 1973. Heinemann Medical Books, London, 1974, p. 170.

    Google Scholar 

  23. Marx S.J., Aurbach G.D. Renal receptors for calcitonin: coordinate occurrence with calcitonin-activated adenylate cyclase. Endocrinology 97: 448, 1975.

    Article  CAS  PubMed  Google Scholar 

  24. Lonigro A.J., Itskovitz H.D., Crowshaw K., McGiff J.C. Dependance of renal blood flow on prostaglandin synthesis in the dog. Circ. Res. 32: 712, 1973.

    Article  CAS  PubMed  Google Scholar 

  25. Lee J.B., Crowshaw K., Takman B.H., Attrep K.A. The identification of prostaglandins E2, F2 and A2 from rabbit kidney medulla. Biochem. J. 105: 1251, 1966.

    Google Scholar 

  26. Lee J.B., McGiff J.C., Kannengiesser H., Mudd J.G., Aykent Y., Frawley T.E. Anthypertensive and natriuretic activity of prostaglandin A1 in human hypertension. Clin. Res. 17: 456, 1969.

    Google Scholar 

  27. Larsson C., Anggard E. Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney. Eur. J. Pharmacol. 21: 30, 1973.

    Article  CAS  PubMed  Google Scholar 

  28. McGiff J.C., Crowshaw K, Terragno N.A., Lonigro A.J. Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II. Circ. Res. Suppl. 27: 121, 1970.

    Article  CAS  Google Scholar 

  29. Fulgraff G., Brandenbusch G., Heintze K., Meiforth A. Renal effect of the prostaglandin A1 and E2 in hydrated and hydropenic dogs. Experientia 31: 65, 1975.

    Article  CAS  PubMed  Google Scholar 

  30. Terragno N.A., Malik K.A., Nasyletti A., Terragno D.A., McGiff J.C. Renal Prostalgandins. In: Samuelsson B., Paoletti R. (Eds.), Advances in prostaglandin and thromboxane research. Raven Press, New York, 1976, Vol. 2, p. 561.

    CAS  PubMed  Google Scholar 

  31. Bergstrom S. Prostaglandins: members of a new hormonal system. Science 157: 382, 1971.

    Article  Google Scholar 

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Authors and Affiliations

  1. Istituto di Patologia Medica II, Università di Catania, Ospedale Garibaldi, Piazza S.M. di Gesu, 95100, Catania, Italy

    C. E. Fiore, A. Petralito, A. Liuzzo, R. A. Mangiafico & S. Gibiino

  2. Istituto di Patologia Generale, Università di Catania, Ospedale Garibaldi, Piazza S.M. di Gesu, 95100, Catania, Italy

    M. C. Mazzarino & G. Malaponte

Authors
  1. C. E. Fiore
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  2. A. Petralito
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  3. M. C. Mazzarino
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  4. A. Liuzzo
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  5. G. Malaponte
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  6. R. A. Mangiafico
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  7. S. Gibiino
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Fiore, C.E., Petralito, A., Mazzarino, M.C. et al. Effects of ketoprofen on the calciuric and uricosuric activities of calcitonin in man. J Endocrinol Invest 4, 81–84 (1981). https://doi.org/10.1007/BF03349420

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  • DOI: https://doi.org/10.1007/BF03349420

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