Abstract
Thyroid hormone abnormalities in serum were investigated in 47 patients with diabetes mellitus. Although no significant differences in T4 were found between normal subjects and diabetics, a group of diabetics whose fasting blood sugar levels were over 250 mg/dl showed significantly higher reverse T3(rT3) (p < 0.01) and lower T3 levels (p < 0.05) than healthy controls. A significant correlation was observed between rT3and FFA levels in diabetics. Moreover, patients in diabetic ketoacidosis showed markedly high rT3 with low T3 levels. With insulin treatment, these levels returned to normal in several days. These findings suggest that the reduction of T3and the increase of rT3 may indicate an adaptation to limit catabolism in diabetics.
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Ingbar S.H., Braverman L.E. Active form of the thyroid hormone. Annu. Rev. Med. 26: 443, 1975.
Utiger R.D. Serum triiodothyronine in man. Annu. Rev. Med. 25: 289, 1974.
Sterling K, Lazarus J.N. The thyroid and its control. Annu. Rev. Physiolog. 39: 349, 1977.
Miskiewicz S.J., Arnett B.B., Simon G.E. Evaluation of a glucose oxidase-peroxidase method adapted to the single-channel autoanalyzer and SMA 12/60. Clin. Chem. 19: 253, 1973.
Itaya K., Ui M. Colorimetric determination of free fatty acids in biological fluids. J. Lipid Res. 6: 16, 1965.
Chopra I.J., Chopra U., Smith S.R., Reza M., Solomon D.H. Reciprocal changes in serum concentrations of 3, 3′, 5′-triiodothyronine (reverse T3) and 3, 3′, 5-triiodothyronine (T3) in systemic illnesses. J. Clin. Endocrinol. Metab. 41: 1043, 1975.
Bermudez F., Surks M.I., Oppenheimer J.H. High incidence of decresead serum triiodothyronine concentration in patients with nonthyroidal disease. J. Clin. Endocrinol. Metab. 41: 27, 1975.
Vegenakis A.G., Burger A., Portnay G.I., Rudolph M., O’Brian J.T., Azizi F., Arky R.A., Nicod P., Ingbar S.H., Braverman L.E. Diversion of peripheral thyroxine metabolism from activating to inactivating pathways during complete fasting. J. Clin. Endocrinol. Metab. 41: 191, 1975.
Spaulding S.W., Chopra I.J., Sherwin R.S., Lyall S.S. Effect of caloric restriction and dietary composition on serum T3 and reverse T3 in man. J. Clin. Endocrinol. Metab, 42: 197, 1976.
Saunders J., Hall S.E.H., Sonksen P.H. Thyroid hormones in insulin requiring diabetes before and after treatment. Diabetologia 15: 29, 1978.
Eisenstein Z., Haag S., Vagenakis A.G., Fang S.L., Ransil B., Burger A., Balsam A., Braverman L.E., Ingbar S.H. Effect of starvation on the production and peripheral metabolism of 3, 3′, 5′-triiodothyronine in euthyroid obese subjects. J. Clin. Endocrinol. Metab. 47: 889, 1978.
Pittman C.S., Suda A.K., Chambers J.B. Jr., Mcdaniel H.G., Ray G.Y., Preston B.K. Abonormalities of thyroid hormone turnover in patients with diabetes mellitus before and after insulin therapy. J. Clin. Endocrinol. Metab. 48: 854, 1979.
Pittman C.S., Suda A.K., Chambers J.B. Jr., Ray G.Y. Impaired 3, 5, 3′-triiodothyronine (T3) production in diabetic patients. Metabolism 28: 333, 1979.
Balsam A., Ingbar S.H. The influence of fasting, diabetes, and several pharmaco-logical agents on the pathways of thyroxine metabolism in rat liver. J. Clin. Invest. 62: 415, 1978.
Cahill G.F., Jr. Starvation in man. N. Engl. J. Med. 282: 668, 1975.
Williams R.H., Porte D. Jr. Role of insulin and other factors in the integration of nutrient metabolism In: Williams R.H. (Ed.), Textbook of endocrinology, ed. S. W.B. Sunders Company, Philadelphia, 1974, p. 542.
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Fujii, S., Akai, T., Tanaka, S. et al. Thyroid hormone abnormalities in patients with diabetes mellitus. J Endocrinol Invest 4, 71–74 (1981). https://doi.org/10.1007/BF03349418
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DOI: https://doi.org/10.1007/BF03349418