Abstract
The 24-h pattern of integrated serum TSH concentrations has been investigated in 12 healthy adult males and 14 pubertal boys by means of continuous blood flow sampling. For every subject the integrated values and the mean concentrations, corresponding to the entire 24 hours, to the daytime (08:00–20:00) and to the nighttime (20:00–08:00) were calculated. A circadian rhythmicity has been shown in boys, as well as in adults. The mean TSH concentrations were significantly higher in boys with respect to adults. The nyctohemeral maximum was mostly recorded in pubertal boys after sleep and in adults before the onset of sleep. Mean and integrated concentrations corresponding to the nighttime period were significantly higher than those corresponding to the daytime in both groups. In conclusion, the 24-h TSH secretion seems different in boys with respect to adults both in the icreased concentrations and in the time (generally after the onset of sleep) of the maximum.
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Alford F.P., Baker H.W.G., Burger H.G., De Kretzer D.M., Hudson B., Johns M.W., Masterton J.P, Patel Y.C, Rennie G.C. Temporal patterns of integrated plasma hormone levels during sleep and wakefulness. I) Thyroid-stimulating hormone, growth hormone and cortisol. J. Clin. Endocrinol. Metab. 37: 841, 1973.
Parker D.C., Pekary A.E., Hershman J.M. Effect of normal and reversed sleep wake cycles upon nyctohemeral rhythimicity of plasma thyrotropin; evidence suggestive of an inhibitory influence in sleep. J. Clin. Endocrinol. Metab. 43: 318, 1976.
Lucke C., Hehrmann E., Von Mayersbach K., Von Zur Mühlen A. Studies on circadian variations of plasma TSH, thyroxine and triiodothyronine in man. Acta Endocrinol. (Kbh.) 86: 81, 1977.
Weeke J. Circadian variations of the serum thyrotropin level in normal subjects. Scand. J. Clin. Lab. Invest. 31: 337, 1973.
Boyar R., Finkelstein J., Roffwarg H., Kapen C., Weitzmann E.D., Hellmann L. Synchronization of augmented luteinizing hormone secretion during puberty. N. Engl. J. Med. 287: 582, 1972.
Weitzmann E.D., Boyar M., Kapen S., Hellmann S. The relationship of sleep and sleep stage to neuroendocrine secretion and biological rhythms in man. Rec. Progr. Horm. Res. 31: 399, 1975.
Lee I.A., Plotnick L.P., Steele R.E., Thompson R.G., Blizzard R.M. Integrated concentration of luteinizing hormone and puberty. J. Clin. Endocrinol. Metab. 43: 168, 1976.
Thompson R.G., Plotinik L., Kowarski A., Blizzard R.M. The pubertal growth spurt: role of human growth hormone. In: Raiti S, (Ed.), Advances in human growth research research. Dhew Publ. n. (NIH) 74–612, Washington, 1973, p. 670
Blizzard R.M., Thompson R.C., Baghdassarian A., Kowarski A., Migeon C.J., Rodriguez A. The interrelationship of steroids, growth hormone, and other hormones on pubertal growth. Jn: Grumbach M.M., Grave C.D., Mayer F.E. (Eds.), The control of the onset of puberty. John Wiley & Sons, New York, 1974, p. 342.
Giusti M., Bolognesi F., Parazzi F., Mortara R., Giordano G. Ritmo sogno-veglia e tassi integrati di alcuni ormoni ipofisari in soggetti in crisi puberale. Minerva Endocrinol. 3: 71, 1978.
Judd H.L., Parker D.C., Yen S.S.C. Sleep-wake patterns of LH and testosterone release in prepubertal boys. J. Clin. Endocrinol. Metab. 44: 865, 1977.
Tanner J.M. Growth at adolescence, with a general consideration of the effects of hereditary and environmental factors upon growth and maturation from birth to maturity. In: Growth at adolescence, 2nd Ed. Blackwell, Oxford, 1962. (cited by P. Franchimont, H. Burger, “Human growth hormone and gonadotrophins in health and disease”, North-Holland Amsterdam Oxford, American Elsevier publishing company Inc., New York 1975, p. 187.
Kowarski A., Thompson R.G., Migeon C.J., Blizzard R.M. Determination of integrated plasma concentrations and secretion rates of human growth hormone. J. Clin Endocrinol. Metab. 32: 356, 1971.
Giordano G., Giusti M. In: Polleri A., Me Leod R.M. (Eds.), Neuroendocrinology: biological and clinical aspects. Serono Symposia, Academic Press, London, 1979, p. 117.
Winkler R.L., Hays W.L. Statistics: probability, inference and decision. Holt, Rinehart and Wiston, New York, 1975, p. 862.
Fukuda M., Greer M.A. The effect of basal hypothalamic deafferentation on the hyctohemeral rhythm of TSH. Endocrinology 97: 749, 1975.
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Minuto, F., Bagnasco, M., Giusti, M. et al. Twenty-four hour profile of integrated TSH concentration in puberty. J Endocrinol Invest 4, 7–10 (1981). https://doi.org/10.1007/BF03349406
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DOI: https://doi.org/10.1007/BF03349406