Abstract
Measurements of serum thyroxine binding globulin (TBG) by a ligand partitioning sandwich assay were performed in 173 healthy subjects between three months and 92 yr of age. Significant sex-related differences were observed in subjects aged 21 to 50 yr. In males, serum TBG declined progressively reaching a nadir in the fourth decade and then increased with advancing age. In contrast, no significant age-related variation was observed in females.
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Dowling J.T., Freinkel N., Ingbar S.H. Effect of diethyistilbestrol on the biiiding of thyroxine in the serum. J. Clin. Endocrinol. Metab. 16: 1491, 1956.
Federman D.D., Robbins J., Rall J.E. Effects of methyl testosterone on thyroid function, thyroxine metabolism, and thyroxine-binding protein. J. Clin. Invest. 37: 1024, 1958.
Braverman L.E., Foster A.E., Ingbar S.H. Sex-related differences in the binding in serum of thyroid hormones. J. Clin. Endocrinol. Metab. 27: 227, 1967.
Refetoff S., Hagen S.R., Selenkow H.A. Estimation of the T4 binding capacity of serum TBG and TBPA by a single T4 load ion exchange resin method. J. Nucl. Med. 13: 2, 1972.
Sardano G., Pacchiarotti A., Baschieri L. Valutazione clinica di un nuovo metodo di dosaggio della thyroxine binding globulin (TBG). Atti del XVII Congresso Nazionale della Società Italiana di Endocrinologia, Torino, May 17–20, 1978, p. C–88 (abstract).
Braverman L.E., Dawber N.A., Ingbar S.H. Observations concerning the binding of thyroid hormones in sera of normal subjects of varying ages. J. Clin. Invest. 45: 1273, 1966.
Hesch R.D., Gatz J., Jüppner H., Stubbe P. TBG-dependency of age related variations of thyroxine and triiodothyronine. Horm. Metab. Res. 9: 141, 1977.
Fisher D.A., Sack J., Oddie T.H., Pekary A.E., Hershman J.M., Lam R.W., Parslow M.E. Serum T4, TBG, T3 uptake, T3, reverse T3 and TSH concentrations in children 1 to 15 years of age. J. Clin. Endocrinol. Metab. 45: 191, 1977.
Ingbar S.H., Waterhouse C., Cushman P. Observations on the nature of the underlying disorder and the occurrence of plasma transport abnormalities in a patient with an idiopathic increase in the plasma thyroxine-binding globulin. J. Clin. Invest. 43: 2266, 1964.
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Bigazzi, M., Sardano, G., Martino, E. et al. Age- and sex-related variations of serum thyroxine binding globulin. J Endocrinol Invest 3, 439–440 (1980). https://doi.org/10.1007/BF03349386
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DOI: https://doi.org/10.1007/BF03349386