Abstract
We have studied the effects of treatment with human chorionic somatommatropin (hCS) in the dwarf mouse on the weight and ultrastructure of the testes and accessory sex glands. We used animals of the Snell-Bagg (dw/dw) strain, whose hypophyses secrete neither prolactin nor growth hormone. The effects found were compared with those produced by a similar treatment with ovine prolactin. The administration of hCS causes a significant increase in the wet weight of the testes and accessory sex glands. Ultrastructural observations have demonstrated that hCS is able to stimulate spermiogenesis and the secretory function of the accessory sex glands. Prolactin, as shown in previous reports in the literature, has a similar action on the male reproductive system. However, contrary to the observation after prolactin therapy, nomatings were observed after treatment with hCS.
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Arezzini C., Fruschelli C., Neri P. Weight gain and histological changes in testis and accessory sex glands in the dwarf mouse treated with human chorionic somatomammotropin (hCS). IRCSMed. Sci. 1:20, 1973.
Tarli P., Arezzini C., Neri P., Fruschelli C., Ricci C. Relazioni di attività e di struttura tra ormone somatotropo, prolattina (ipofisaria e deH’amnios) e somatomammotropina corionica umana. In: Muller E.E. and Piazzi S.E. (Eds.), Atti delle Giornate Endocrinologiche Senesi. Ed. ISVT Sclavo, Siena, Italy, 1975, p. 3.
Neri P., Arezzini C., Fruschelli C., Müller E.E., Fioretti P., Genazzani A.R. Effects of human chorionic somatomammotropin on the male reproductive apparatus of rodents and on placental steroids during human pregnancy. In: Müller E.E., Pecile A. (Eds.), Growth hormone and related peptides. Proc. Third Int. Symp., Milano, Excerpta Medica, 1975, p. 345.
Lewis U.J., Cheever E.V., Vanderlaan W.P. Studies on the growth hormone of normal and dwarf mice. Endocrinology 76: 210, 1965.
Lewis U.J. Growth hormone of normal and dwarf mice. Mem. Soc. Endocrinol. 15:179, 1967.
Grüneberg H. In: Martinus Nijhoff (Ed.), The genetics of the mouse. The Hague, 1952, p. 122.
Sinha Y.N., Salocks C.B., Vanderlaan W.P. Pituitary and serum concentrations of prolactin and GH in Snell dwarf mice. Proc. Soc. Exp. Biol. Med. 150: 207, 1975.
Cheever E.V., Seavey B.K., Lewis U.J. Prolactin of normal and dwarf mice. Endocrinology 85: 698, 1969.
Bartke A. Prolactin deficiency in genetically sterile dwarf mice. Mem. Soc. Endocrinol. 15:193, 1967.
Bartke A., Goldman B.D., Bex F., Dalterio S. Effects of prolactin (PRL) on pituitary and testicular function in mice with hereditary PRL deficiency. Endocrinology 101:1760, 1977.
Neri P., Tarli P., Arezzini C., Cocola F., Pallini V., Ricci C. Effects of pH on conformation and biological activity of Human chorionic somatomammotropin (HCS). Ann. Sclavo 72:663, 1970.
Snedecor G.W., Cochran W.G. Statistical methods, ed. 6. Iowa State University Press, Ames, Iowa, 1968, p. 116.
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Arezzini, C., Alessandrini, C., Gerli, R. et al. Ultrastructural modifications of the testes and accessory sex glands of genetically dwarf mice after treatment with human chorionic somatomammotropin. J Endocrinol Invest 2, 195–200 (1979). https://doi.org/10.1007/BF03349313
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DOI: https://doi.org/10.1007/BF03349313