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Stimulation of prolactin release by intravenous cimetidine: a dose-response study

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Abstract

The PRL response to iv cimetidine was tested in 8 healthy males and 8 females at 4 different dose levels (0.75, 1.5, 3.0 and 6.0 mg/kg bw). Serum PRL levels were significantly increased in comparison with a placebo study by the second cimetidine dose in both sexes. The PRL response was significantly higher in females than in males at all but the lowest dose tested. A significant correlation between the cimetidine dose and the PRL response was observed. There were no significant modifications in serum GH, LH, FSH, IRI and glucose. Present findings demonstrate that the stimulation of PRL release by iv cimetidine is quite specific and dose-dependent.

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Authors and Affiliations

  1. 2nd Department of Medicine and Department of Nuclear Medicine, Fatebenefratelli Hospital, Milano, Italy

    R. Caldara, C. Barbieri, M. Romussi & C. Ferrari

  2. 3rd Medical Clinic, University of Milano, Milano, Italy

    L. Bierti & M. Cambielli

Authors
  1. R. Caldara
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  2. L. Bierti
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  3. C. Barbieri
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  4. M. Cambielli
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  5. M. Romussi
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  6. C. Ferrari
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Caldara, R., Bierti, L., Barbieri, C. et al. Stimulation of prolactin release by intravenous cimetidine: a dose-response study. J Endocrinol Invest 2, 79–81 (1979). https://doi.org/10.1007/BF03349280

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  • DOI: https://doi.org/10.1007/BF03349280

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