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Relationship between thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins years after administration of radioiodine for Graves’ disease: retrospective clinical survey

Journal of Endocrinological Investigation volume 19, pages 682–686 (1996)Cite this article

Abstract

Thyroid-stimulating antibody (TSAb) activity and the TSH-binding inhibitory immunoglobulin (TBII) index were assessed in 158 patients with Graves’ disease who had been treated with 131I 6–14 years earlier. Twenty-one patients (13%) were still hyperthyroid, 45 (28%) were euthyroid, 44 (28%) were subclinically hypothyroid, and 48 (30%) were overtly hypothyroid. Positive results were obtained in 10 (48%) of the 21 patients with hyperthyroidism for both TSAb and TBII assays, and in 3 patients (14%) in one of the assays. In contrast, only two (5%) patients with subclinical hypothyroidism and 1 (2%) patient with overt hypothyroidism tested positive in both assays, and 11 (25%) subclinically hypothyroid patients and 15 (31%) overtly hypothyroid patients tested positive in one of the assays. The correlation coefficients between TSAb and TBII were 0.88 (p<0.01) in hyperthyroid patients, 0.49 (p<0.01) in euthyroid patients, 0.34 (p<0.05) in subclinically hypothyroid patients, and 0.12 (p>0.05) in patients with overt hypothyroidism. Findings indicate the presence of long-term changes in the population of TSH receptor antibodies years after 131I treatment, which may influence thyroid function.

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Affiliations

  1. Department of Clinical Biology and Hormonal Regulation, Tohoku University School of Medicine, Sendai, Japan

    K. Yoshida & H. Hori

  2. Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan

    Y. Aizawa, N. Kaise, H. Fukazawa, Y. Kiso, N. Sayama, K. Mori & K. Abe

Authors
  1. K. Yoshida
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  2. Y. Aizawa
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  3. N. Kaise
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  4. H. Fukazawa
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  5. Y. Kiso
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  6. N. Sayama
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  7. K. Mori
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  8. H. Hori
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  9. K. Abe
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Yoshida, K., Aizawa, Y., Kaise, N. et al. Relationship between thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins years after administration of radioiodine for Graves’ disease: retrospective clinical survey. J Endocrinol Invest 19, 682–686 (1996). https://doi.org/10.1007/BF03349039

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  • DOI: https://doi.org/10.1007/BF03349039

Keywords

  • Graves’ disease
  • radioiodine treatment
  • TSH receptor antibody