Skip to main content
SpringerLink
Log in

Regulation of mouse placental lactogen-II secretion by transforming growth factor-α after midpregnancy

  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

We investigated whether transforming growth factor-α (TGF-α) regulates mouse placental lactogen-II (mPL-II) secretion by cells from day 12 of pregnancy. TGF-α significantly inhibited mPL-II secretion by the third and fourth day of culture, and then stimulated mPL-II secretion from the sixth day. The inhibitory and stimulatory effects of TGF-α on mPL-II secretion were dosedependent, and the lowest concentration of TGF-α-which caused significant inhibition or stimulation of mPL-II secretion was 10 ng/ml. When TGF-α treatment of placental cells was begun on the fifth day of the culture, significant stimulation of mPL-II secretion was observed 3 days later. TGF-=α inhibited steady-state levels of mPL-II mRNA on the third day of culture but stimulated steady-state levels of mPL-II mRNA on the seventh day of culture. These results suggest that TGF-α biphasically regulates mPL-II secretion through regulation of mPL-II gene expression after midpregnancy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hall J., Talamantes F. Immunocytochemical localization of mouse placental lactogen in the mouse placenta. J. Histochem. Cytochem. 32: 379, 1984.

    Article  CAS  PubMed  Google Scholar 

  2. Yamaguchi M., Ogren L., Endo H., Thordarson G., Bigsby R.M., Talamantes F. Production of mouse placental lactogen-I and placental lactogen-II by the same giant cells. Endocrinology 131: 1595, 1992.

    CAS  PubMed  Google Scholar 

  3. Yamaguchi M., Ogren L., Endo H., Soares M.J., Talamantes F. Co-localization of placental lactogen-I, placental lactogen-II, and proliferin in the mouse placenta at midpregnancy. Biol. Reprod. 51: 1188, 1994.

    Article  CAS  PubMed  Google Scholar 

  4. Yamaguchi M., Sakata M., Ogura K., Adachi K., Mammoto A., Miyake A. Inhibition of mouse placental lactogen-II release from placental cells by interleukin-I after midpregnancy. J. Endocrinol. 147: 367, 1995.

    Article  Google Scholar 

  5. Yamaguchi M., Ogren L., Southard J.N., Kurachi H., Miyake A., Talamantes F. Interleukin-6 inhibits mouse placental lactogen-II but not mouse placental lactogen-I secretion in vitro. Proc. Natl. Acad. Sci. USA 90: 11905, 1993.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Yamaguchi M., Taga T., Kishimoto T., Miyake A. Cytokine that use gp130 as a signal transducer stimulate mouse placental lactogen-I (mPL-I) but inhibit mPL-II production in vitro. Biol. Reprod. 53: 399, 1995.

    Article  CAS  PubMed  Google Scholar 

  7. Yamaguchi M., Ogren L., Barnard R., Sawada T., Miyake A., Talamantes F. Selective inhibition of mouse placental lactogen II secretion by tumor necrosis factor-α. J. Endocrinol. 143: 95, 1994.

    Article  CAS  PubMed  Google Scholar 

  8. Yamaguchi M., Kurachi H., Tadokoro C., Sakata M., Yoshimoto Y., Masumoto N., Tasaka K., Miyake A. Tumor necrosis factor-α (TNF-α) inhibits expression of mouse placental lactogen-II through TNF type-I but not type-II receptor. Biochem. Biophys. Res. Commun. 202: 1599, 1994.

    Article  CAS  PubMed  Google Scholar 

  9. Yamaguchi M., Ogren L., Endo H., Thordarson G., Kensinger R., Talamantes F. Epidermal growth factor stimulates mouse placental lactogen-I but inhibits mouse placental lactogen-II secretion in vitro. Proc. Natl. Acad. Sci. USA 89: 11396, 1992.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Yamaguchi M., Ogren L., Kurachi H., Hirota K., Imai T., Talamantes F. Opposite effects of transforming growth factor-α and epidermal growth factor on mouse placental lactogen-I secretion. Proc. Natl. Acad. Sci. USA 92: 2830, 1995.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Yamaguchi M., Maeda T., Yoneda M., Nishizak; T., Miyake A. Posttranscriptional inhibition of mouse placental lactogen-II secretion by transforming growth factor-β1: synergistic effects with epidermal growth factor and interleukin-6. Biol. Reprod. 53: 373, 1995.

    Article  CAS  PubMed  Google Scholar 

  12. Yamaguchi M., Tasaka K., Ogura K., Sakata M., Mizuki J., Miyake A. Activin inhibits but inhibin activates mouse placental lactogen-II secretion. J. Endocrinol. 146: 469, 1995.

    Article  CAS  PubMed  Google Scholar 

  13. Yamaguchi M., Imai T., Maeda T., Sakata M., Miyake A. Cyclic adenosine-3’,5’-monophosphate stimulates mouse placental lactogen-I (mPL-I) secretion but inhibits mPL-II secretion at midpregnancy. Endocrinology 136: 1388, 1995.

    CAS  PubMed  Google Scholar 

  14. Finley E.L., King J.S., Ramsdell J.S. Human pituitary somatotropes express transforming growth factor-α and its receptor. J. Endocrinol. 141: 547, 1994.

    Article  CAS  PubMed  Google Scholar 

  15. Massague J. Epidermal growth factor-like transforming growth factor: interaction with epidermal growth factor receptors in human placental membranes and A431 cells. J. Biol. Chem. 258: 13614, 1983.

    CAS  PubMed  Google Scholar 

  16. Marquardt H., Hunkapiller M.W., Hood L.E., Todaro G.J. Rat transforming growth factor type 1: structure and relation to epidermal growth factor. Science 223: 1079, 1984.

    Article  CAS  PubMed  Google Scholar 

  17. Murdoch G.H., Potter E., Nicolaisen A.K., Evans R.M., Rosenfeld M.G. Epidermal growth factor rapidly stimulates prolactin gene transcription. Nature 300: 192, 1982.

    Article  CAS  PubMed  Google Scholar 

  18. Miyake A., Tasaka K., Otsuka S., Kohmura H., Wakimoto H., Aono T. Epidermal growth factor stimulates secretion of rat pituitary luteinizing hormone in vitro. Acta Endocrinol. (Copenh.) 108: 175, 1985.

    CAS  Google Scholar 

  19. Wilcox J.N., Derynck R. Developmental expression of transforming growth factor alpha and beta in mouse fetus. Mol. Cell. Biol. 8: 3415, 1988.

    CAS  PubMed Central  PubMed  Google Scholar 

  20. Soares M.J., Colosi P., Talamantes F. The development and characterization of a homologous radioimmunoassay for mouse placental lactogen. Endocrinology 110: 668, 1982.

    Article  CAS  PubMed  Google Scholar 

  21. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162. 156, 1987.

    Article  CAS  PubMed  Google Scholar 

  22. Yamaguchi M., Ogura K., Sakata M., Miyake A. Transforming growth factor-α regulates subpopulation of giant cells which secrete mouse placental lactogen-I (mPL-I) and/or mPL-II at midpregnancy. J. Endocrinol. Invest. 19: 146, 1996.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka, 565, Japan

    M. Yamaguchi Dr., K. Kobayashi & A. Miyake

Authors
  1. M. Yamaguchi Dr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Miyake
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamaguchi, M., Kobayashi, K. & Miyake, A. Regulation of mouse placental lactogen-II secretion by transforming growth factor-α after midpregnancy. J Endocrinol Invest 19, 598–602 (1996). https://doi.org/10.1007/BF03349024

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03349024

Key-words

Search

Navigation