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Combined treatment with growth hormone and luteinizing hormone releasing hormone-analogue (LHRHa) of pubertal children with familial short stature

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Abstract

We evaluated the 12 month growth of 18 pubertal children with familial short stature randomly assigned to clinical follow-up (group A), GH treatment alone (group B) and GH+LHRH analogue (LHRHa) treatment (group C). Height velocity increased significantly compared to baseline in groups A and B (4.7±0.4 vs 6.6±0.6 and 4.4±0.3 vs 8±1 respectively), but not in C (5±0.5 vs 6.5±0.4). Moreover in group B height and height prognosis standard deviation score SDS) also were higher (−2.2±0.2 vs−1.7±0.2 and 1.8±0.3 vs −1±0.2, respectively). Comparisons among the groups showed a significant increase in group B vs the other groups of height velocity SDS (3.9±1.3 vs 0.4+1 and 0.3±0.7) and of height prognosis SDS (−1±0.2 vs −2.4±0.3 and −2.4±0.3). In conclusion, after one-year treatment, GH seems to be more effective in stimulating growth than GH±LHRHa, even if studies of longer duration and/or follow-up are needed.

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Authors and Affiliations

  1. Istituto di Clinica Pediatrica, University of Parma, Parma, Italy

    Sergio Bernasconi M.D., L. Ghizzoni & A. Alberini

  2. Cattedra di Endocrinologia, Istituto di Clinica Medica Policlinico, Modena, Italy

    P. Tondi, V. Salvioli, A. Baldini & C. Carani

Authors
  1. C. Volta
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  2. Sergio Bernasconi M.D.
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  3. P. Tondi
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  4. V. Salvioli
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  5. L. Ghizzoni
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  6. A. Baldini
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  7. A. Alberini
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  8. C. Carani
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Volta, C., Bernasconi, S., Tondi, P. et al. Combined treatment with growth hormone and luteinizing hormone releasing hormone-analogue (LHRHa) of pubertal children with familial short stature. J Endocrinol Invest 16, 763–767 (1993). https://doi.org/10.1007/BF03348921

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  • DOI: https://doi.org/10.1007/BF03348921

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