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Insulin-like growth factor I values in patients on maintenance hemodialysis: Relationship to growth hormone and albumin levels

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Abstract

Twenty-seven uremic patients (blood urea: 58.2±2.2 mmol/l; blood creatinine: 1,069±53 μnol/l; mean±SE) on maintenance dialysis were investigated immediately before and after a dialysis session. Control data were obtained from 30 normal volunteers. Before dialysis, circulating levels of insulin-like growth factor I (IGF-I) were similar in anuric and nonanuric patients, averaging 305±24 μg/l, a value not different from that observed in normal controls (262±16 μg/l). IGF-I levels were not modified by dialysis. In contrast, GH values were significantly higher in uremic patients (3.6± 0.6 μg/l) than in normal controls (2.5±0.5 μg/l) and decreased significantly after the dialysis session (0.8±0.1 μg/). IGF-I values were positively correlated with GH and albumin, but not with the various parameters of renal insufficiency, suggesting that in chronic renal failure, synthesis of IGF-I appears to be regulated, as in normal subjects, by growth hormone and nutritional status.

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References

  1. Takano K., Hall K., Kastrup K.W., Hizuka N., Shizume K., Kawai K., Akimoto M., Takuma T., Sugino N. Serum somatomedin A in chronic renal failure. J. Clin. Endocrinol. Metab. 48: 371, 1979.

    Article  PubMed  CAS  Google Scholar 

  2. Phillips LS., Kopple J.D. Circulating somatomedin activity and sulfate levels in adults with normal and impaired kidney function. Metabolism 30: 1091, 1981.

    Article  PubMed  CAS  Google Scholar 

  3. Phillips S.L., Fusco A.C., Unterman T.G., del Greco F. Somatomedin inhibitor in uremia. J. Clin. Endocrinol. Metab. 59: 764, 1984.

    Article  PubMed  CAS  Google Scholar 

  4. Lee P.D.K., Hintz R.L., Sperry J.B., Baxter R.C., Powell D.R. IGF binding proteins in growth-retarded children with chronic renal failure. Pediatr. Res. 26: 308, 1989.

    Article  PubMed  CAS  Google Scholar 

  5. Blum F., Ranke M.B., Kietzmann K., Tönshoff B., Mehls O. Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uremia. Pediatr. Nephrol. 5: 539, 1991.

    Article  PubMed  CAS  Google Scholar 

  6. Baxter R.Ç., Brown A.S., Turtle J.R. Radioimmunoassay for somatomedin C: comparison with radioreceptor assay in patients with growth-hormone disorders, hypothyroidism, and renal failure. Clin. Chem. 28: 488, 1982.

    PubMed  CAS  Google Scholar 

  7. Goldberg A.C., Trivedi B., Delmez JA, Harter H.R., Daughaday W.H. Uremia reduces serum insulin-like growth factor I, increases insulin-like growth factor II, and modifies their serum protein binding. J. Clin. Endocrinol. Metab. 55: 1040, 1982.

    Article  PubMed  CAS  Google Scholar 

  8. Powell D.R., Rosenfeld R.G., Baker B.K., Liu F., Hintz R.L. Serum somatomedin levels in adults with chronic renal failure: the importance of measuring insulin-like growth factor I (IGF-I) and IGF-II in acid-chromatographed uremic serum. J. Clin. Endocrinol. Metab. 63: 1186, 1986.

    Article  PubMed  CAS  Google Scholar 

  9. Powell D.R., Rosenfeld R.G., Sperry J.B., Baker B.K., Hintz R.L. Serum concentrations of insulin-like growth factor (IGF)-1, IGF-2 and unsaturated somatomedin carrier proteins in children with renal failure. Am. J. Kidney Dis. 10: 287, 1987.

    PubMed  CAS  Google Scholar 

  10. Koch V.H., Lippe B.M., Nelson P.A., Boechat M.I., Sherman B.M., Fine R.N. Accelerated growth after recombinant human growth hormone treatment of children with chronic renal failure. J. Pediatr. 115: 365, 1989.

    Article  PubMed  CAS  Google Scholar 

  11. Jacob V., Le Carpentier J.E., Salzano S., Naylor V., Wild G., Brown C.B., El Nahas A.M. IGF-I, a marker of undernutrition in hemodialysis patients. Am. J. Clin. Nutr. 52: 39, 1990.

    PubMed  CAS  Google Scholar 

  12. Hokken-Koelega A.C.S., Hackeng W.H.L., Stijnen T., Wit J.M., de Muinck Keizer-Schrama S.M.P.F., Drop S.L.S. Twenty-four-hour plasma growth hormone (GH) profiles, urinary GH excretion, and plasma insulin-like growth factor-I and -II levels in prepubertal children with chronic renal insufficiency and severe growth retardation. J. Clin. Endocrinol. Metab. 71: 688, 1990.

    Article  PubMed  CAS  Google Scholar 

  13. Virasoro E., Copinschi G., Bruno O.D., Leclercq R. Radioimmunoassay of human growth hormone using a charcoal-dextran separation procedure. Clin. Chim. Acta 31: 294, 1971.

    Article  PubMed  CAS  Google Scholar 

  14. Furlanetto R.W., Underwood L.E., Van Wyk J.J., D’Ercole A.J. Estimation of somatomedin-C levels in normals and patients with pituitary disease by radio-immunoassay. J.Clin. Invest. 60: 648, 1977.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  15. Furlanetto R.W., Underwood L.E., Van Wyk J.J., Handwerger S. Serum immunoreactive somatomedin-C is elevated late in pregnancy. J, Clin. Endocrinol. Metab. 41: 695, 1978.

    Article  Google Scholar 

  16. Furlanetto R.W., Marino J.M. Radioimmunoassay of somatomedin C insulin-like growth factor I. In: Barnes D., Sirbasku D.A. (Eds.), Methods in Enzymology, vol. 146, Peptide Growth Factors. Academic Press Inc., New York, 1987, p. 216.

    Chapter  Google Scholar 

  17. Caufriez A., Copinschi G. IGF-I determinations in patients with chronic renal failure: an appraisal of a non-equilibrium RIA method on non acidified unextracted serum. Abstracts of the 71st Annual Meeting of the Endocrine Society: 146, 1991.

  18. Hammerman M. R. The growth hormone-insulin-like growth factor axis in kidney. Am. J. Physiol. 257: F503, 1989.

    PubMed  CAS  Google Scholar 

  19. Samaan N.A., Freeman R.M. Growth hormone levels in severe renal failure. Metabolism 19: 102, 1970.

    Article  PubMed  CAS  Google Scholar 

  20. Donnay S., Garcia-Martin F., Martin-Escobar E., De Arriba G., Agud J.L., Requejo R. Growth hormone response to acute growth hormone releasing hormone administration in uraemic patients on hemodialysis. Nephrol. Dial. Transplant. 7: 246, 1992.

    PubMed  CAS  Google Scholar 

  21. El Bishti M.M., Counahan R., Bloom S.R., Chantler C. Hormonal and metabolic responses to intravenous glucose in children on regular hemodialysis. Am. J.Clin. Nutr. 31: 1865, 1978.

    PubMed  Google Scholar 

  22. Olgaard K., Hagen C., McNeilly A.S. Pituitary hormones in women with chronic renal failure: the effect of chronic intermittent haemodialysis and peritoneal dialysis. Acta Endocrinol. (Copenh.) 80: 237, 1975.

    CAS  Google Scholar 

  23. Stuart M., Lazarus L., Hayes J. Serum somatomedin and growth hormone levels in chronic renal failure. IRCS 2: 1102, 1984.

    Google Scholar 

  24. Hunter W.M., Fonseka C.C., Passmore R. Growth hormone: important role in muscular exercise in adults. Science 150: 1051, 1965.

    Article  PubMed  CAS  Google Scholar 

  25. Hartog M., Havel R.J., Copinschi G., Earll J.M., Ritchie B.C. The relationship between changes in serum levels of growth hormone and mobilization of fat during exercise in man. Quart. J. Exp. Physiol. 52: 86, 1967.

    CAS  Google Scholar 

  26. Berelowitz M., Szabo M., Frohman L.A., Firestone S., Chu L., Hintz R.L. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 212: 1279, 1981.

    Article  PubMed  CAS  Google Scholar 

  27. Van Cauter E., Caufriez A., Kerkhofs M., Van Onderbergen A., Thorner M.O., Copinschi G. Sleep, awakenings, and insulin-like growth factor-I modulate the growth hormone (GH) secretory response to GH-releasing hormone. J. Clin. Endocrinol. Metab. 74: 1451, 1992.

    PubMed  Google Scholar 

  28. Guarnieri G., Toigo G., Situlin R., Carraro M., Tamaro G. The assessment of nutritional status in chronically uremic patients. Contrib. Nephrol. 72: 73, 1989.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Experimental Medicine and Service of Nephrology (Hôpital Erasme), Université Libre de Bruxelles, Brussels, Belgium

    A. Caufriez, D. Abramowicz, J. L. Vanherweghem & G. Copinschi

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  1. A. Caufriez
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  2. D. Abramowicz
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  3. J. L. Vanherweghem
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  4. G. Copinschi
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Caufriez, A., Abramowicz, D., Vanherweghem, J.L. et al. Insulin-like growth factor I values in patients on maintenance hemodialysis: Relationship to growth hormone and albumin levels. J Endocrinol Invest 16, 691–696 (1993). https://doi.org/10.1007/BF03348913

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