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Lack of influence of aromatase and 5α-reductase inhibition on [3H]imipramine binding in the male rat brain

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Abstract

In intact adult male rats an inhibitor of aromatase and an inhibitor of 5α-reductase did not change the characteristics of [3H]imipramine binding sites in cerebral cortex, hypothalamus, and hippocampus. Testosterone, estradiol and dihydrotestosterone prevented the effect of castration on the number of [3H]imipramine binding sites, but had no effect in non-castrated animals. These data suggest that testosterone and its major metabolites, estradiol and dihydrotestosterone, are equally effective with regard to imipramine binding sites.

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Authors and Affiliations

  1. Institute of Pharmacology, University of Modena, Via G. Campi 287, 1-41100, Modena, Italy

    M. Sandrini, A. V. Vergoni & A. Bertolini

Authors
  1. M. Sandrini
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  2. A. V. Vergoni
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  3. A. Bertolini
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Sandrini, M., Vergoni, A.V. & Bertolini, A. Lack of influence of aromatase and 5α-reductase inhibition on [3H]imipramine binding in the male rat brain. J Endocrinol Invest 16, 679–681 (1993). https://doi.org/10.1007/BF03348909

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  • DOI: https://doi.org/10.1007/BF03348909

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