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Thyroid hypofunction related with the progression of human immunodeficiency virus infection

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Abstract

Thyroid function was evaluated in 119 human immunodeficiency virus (HIV) infected patients at different stages of infection, compared with euthyroid normal subjects and hepatitis C virus infected blood donors as control groups. The low T3 state, well documented in severe nonthyroidal illnesses, was not found in these HIV infected patients. They showed lower FT4 levels and higher TSH and TBG values than euthyroid normal controls. These findings suggested a thyroid hypofunction becoming more evident with the progression of the infection as also supported by the presence of antithyroid autoantibodies mainly found in the symptomatic stages of the infection.

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References

  1. Dobs A.S., Dempsey M.A., Ladenson P.W., Polk B.F. Endocrine disorders in men infected with human immunodeficiency virus. Am. J. Med. 84: 611, 1987.

    Article  Google Scholar 

  2. Dluhy R.G. The growing spectrum of HIV-related endocrine abnormalities. J. Clin. Endocrinol. Metab. 70: 563, 1990.

    Article  PubMed  CAS  Google Scholar 

  3. Marks J.B. Endocrine manifestations of human immunodeficiency virus (HIV) infection. Am. J. Med. Sci. 302: 110, 1991.

    Article  PubMed  CAS  Google Scholar 

  4. Strauss K.W. Endocrine complications of the acquired immunodeficiency syndrome. Arch. Intern. Med. 151: 1441, 1991.

    Article  PubMed  CAS  Google Scholar 

  5. Raffi F., Brisseau J.M., Planchon B., Remi J.P., Barrier J.H., Grolleau J.Y. Endocrine function in 98 HIV-infected patients: a prospective study. AIDS 5: 729, 1991.

    Article  PubMed  CAS  Google Scholar 

  6. Sullivan W.M., Kelley G.G., O’Connor P.G., Dickey P.S., Kim J.H., Robins R., Schulman G.I. Hypopituitarism associated with a hypothalamic CMV infection in a patient with AIDS. Am. J. Med. 92: 221, 1992.

    Article  PubMed  CAS  Google Scholar 

  7. Merenich J.A., McDermott M.T., Asp A.A., Harrison S.M., Kidd G.S. Evidence of endocrine involvement early in the course of human immunodeficiency virus infection. J. Clin. Endocrinol. Metab. 70: 566, 1990.

    Article  PubMed  CAS  Google Scholar 

  8. Membrano L., Irony I., Dere W., Kline R., Biglieri E.G., Cobb E. Adrenal cortical dysfunction in acquired immunodeficiency syndrome. J. Clin. Endocrinol. Metab. 65: 482, 1987.

    Article  Google Scholar 

  9. Greene L.W., Cole W., Greene J.B. Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome. Ann. Intern. Med. 101: 497, 1984.

    Article  PubMed  CAS  Google Scholar 

  10. Kalin M.F., Poretsky L., Seres D. S., Zumoff B. Hyporeninemic hypoaldosteronism associated with acquired immuno deficiency syndrome. Am. J. Med. 82: 1035, 1987.

    Article  PubMed  CAS  Google Scholar 

  11. Milligan S.A., Katz M.S., Craven P.C., Strandberg D.A., Russell I.J., Becker R.A. Toxoplasmosis presenting as panhypopituitarism in a patient with the acquired immuno deficiency syndrome Am. J. Med. 77: 760, 1984.

    Article  PubMed  CAS  Google Scholar 

  12. Sano T., Kovacs K., Scheithauer B.W., Rosenblum M.K., Petito C.K., Greco C.M. Pituitary pathology in acquired immuno deficiency syndrome. Arch. Pathol. Lab. Med. 113: 1066, 1989.

    PubMed  CAS  Google Scholar 

  13. Croxson T.S., Rudolph S., Chapman W.E., Miller L.K., Zumoff B., Mildvan D. HTLV-III/LAV infection of the CNS with elevated serum prolactin. Proc. of the 2nd Int. Conf. on AIDS, Paris, 1986.

  14. Croxson T.S., Chapman W.E., Miller L.K., Levit C.D., Senie R., Zumoff B. Changes in the hypothalamic-pituitary-gonadal axis in human immunodeficiency virus infected homosexual men. J. Clin. Endocrinol. Metab. 68: 317, 1989.

    Article  PubMed  CAS  Google Scholar 

  15. Lo Presti J.S., Fried J.C., Spencer C.A., Nicoloff J.T. Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS). Ann. Intern. Med. 110: 970, 1989.

    Article  Google Scholar 

  16. Bourdoux P.P., De Wit S.A., Servais G.M., Clumeck N., Bonnyns M.A. Biochemical thyroid profile in patients infected with the human immunodeficiency virus. Thyroid 1: 147, 1991.

    Article  PubMed  CAS  Google Scholar 

  17. Feldt-Rasmussen U., Sestoft L., Berg H. Thyroid function tests in patients with acquired immuno deficiency syndrome and healthy HIV1-positive out patients. Eur. J. Clin. Invest. 21: 59, 1991.

    Article  PubMed  CAS  Google Scholar 

  18. Orskov H., Lindhardt B., Ulrich K., Ryder L. HTVL-III antibody testing in three Danish blood banks. Vox Sanguinis 51 (Suppll. 1): 9, 1986.

    Google Scholar 

  19. Armitage P., Berry G. Statistical methods in medical research. Blackwell Scientific Publications, 1987.

  20. Pacchiarotti A., Martino E., Bartalena L., Aghini-Lombardi F., Grasso L., Buratti L., Falcone M., Pinchera A. Serum free thyroid hormones in subclinical hypothyroidism. J. Endocrinol. Invest. 9: 315, 1986.

    Article  PubMed  CAS  Google Scholar 

  21. Oppenheimer J.H., Schwartz H.L., Mariash C.N., Kaiser F.E. Evidence for a factor in the sera of patients with non-thyroidal disease which inhibits iodothyronine binding by solid matrices, serum proteins and hepatocytes. J. Clin. Endocrinol. Metab. 54: 757, 1982.

    Article  PubMed  CAS  Google Scholar 

  22. Chopra I.J., Hershman J.M., Pardrige W.M., Nicoloff J.T. Thyroid function in nonthyroidal illnesses. Ann. Intern. Med. 98: 946, 1983.

    Article  PubMed  CAS  Google Scholar 

  23. Kaptein E.M., Grieb D.A., Spencer E.M., Wheeler W.S., Nicoloff J.T. Thyroxine metabolism in the low thyroxine state of critical non-thyroidal illness. J. Clin Endocrinol. Metabolism. 53: 764, 1981.

    Article  CAS  Google Scholar 

  24. Slag M.F., Morley J.E., Elson M.K., Gowson T.W., Nuttal F.Q., Shaper R.B. Hypothyroxinemia in critically ill patients as a predictor of high mortality. JAMA 245: 43, 1981.

    Article  PubMed  CAS  Google Scholar 

  25. Kaptein E.M., Weiner J.M., Robinson W.J., Wheeler W.S., Nicoloff J.T. Relationship of altered thyroid hormone indices to survival in non-thyroidal illnesses. Clin. Endocrinol. (Oxf.) 16: 565, 1982.

    Article  CAS  Google Scholar 

  26. Kaufman D.A., Dlatt R., Townsend R., Mizuno L., Weiner J., Nicoloff J.T. Indices of thyroid function as predictors of outcome in critically ill patients. Clin. Res. 36: 101A, 1988.

    Google Scholar 

  27. Fried J.C., Lo Presti J.S., Micon M., Bauer M., Tuchshmidt J.A., Nicoloff J.T. Serum triiodothyronine values. Prognostic indicators of acute mortality due to Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. Arch. Intern. Med. 150: 406, 1990.

    Article  PubMed  CAS  Google Scholar 

  28. Chopra I.J. An assessment of daily production and significance of thyroidal secretion of 3, 3′, 5′-triiodothyronine (reverse T3) in man. J.Clin. Invest. 58: 32, 1976.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  29. Labdevirta J., Maury C.P.J., Teppo A.M., Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am. J. Med. 85: 289, 1988.

    Article  Google Scholar 

  30. Hober D., Haque A., Wattre P., Beaucaire G., Marton Y. Capron A. Production of tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1) in patients with AIDS. Enhanced level of TNF-α is related to higher cytotoxic activity. Clin. Exp. Immunol. 74: 329, 1989.

    Google Scholar 

  31. Ozawa M., Sato K., Han D., Kawakami M., Tsushima T., Shizume K. Effect of tumor necrosis factor-alpha/cachectin on thyroid hormone metabolism in mice. Endocrinology 123: 1461, 1988.

    Article  PubMed  CAS  Google Scholar 

  32. Bonnyns M., Bourdoux P. Thyroid function and non-thyroidal illness: prevalence of thyroid biochemical abnormalities. Eur. J. Intern. Med. 1: 213, 1990.

    Google Scholar 

  33. Lambert M., Zech F., De Nayer P., Jamez J., Vandercam B. Elevation of serum-thyroxine-binding globulin (but not of cortisol-binding globulin and sex hormone-binding globulin) associated with the progression of human immunodeficiency virus infection. Am. J. Med. 89: 748, 1990.

    Article  PubMed  CAS  Google Scholar 

  34. Grant M.D., Weaver M.S., Tsaukas C., Hoffmann G.W. Distribution of antibodies against denatured collagen in AIDS risk groups and homosexual AIDS patients suggests a link between autoimmunity and the immunopathogenesis of AIDS. J. Immunol. 144: 1241, 1990.

    PubMed  CAS  Google Scholar 

  35. Calabrese L.H. Autoimmune manifestations of human immunodeficiency virus (HIV) infection. Clin. Lab. Med. 8: 269, 1988.

    PubMed  CAS  Google Scholar 

  36. Kopelman R.G., Zolla-Pazner S. Association of human immunodeficiency virus infection and autoimmune phenomena. Am. J. Med. 84: 82, 1988.

    Article  PubMed  CAS  Google Scholar 

  37. Sugihara S., Maruo S., Tsujimura T., Tarutani O., Kohno Y., Hamaoka T., Fujiwara H. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. III Analysis of regulatory cells suppressing the induction of thyroiditis. Intl. Immunol. 2: 343, 1990.

    Article  CAS  Google Scholar 

  38. Via C.S., Shearer G.M. Autoimmunity and the acquired immune deficiency syndrome. Curr. Opin. Immunol. 1: 753, 1989.

    Article  PubMed  CAS  Google Scholar 

  39. Srinivasappa A., Garzelli C., Onodera T., Ray U., Notkins A.L. Virus-induced thyroiditis. Endocrinology 122: 563, 1988.

    Article  PubMed  CAS  Google Scholar 

  40. Frank T.S., Livolsi V.A., Connor A.M. Cytomegalovirus infection of the thyroid in immunocompromised adults. Yale J. Biol. Med. 60: 1, 1987.

    PubMed Central  PubMed  CAS  Google Scholar 

  41. Mollison L.C., Mijch A., McBride G., Vwyer B. Hypothyroidism due to destruction of the thyroid by Kaposi’s sarcoma. Rev. Infect. Dis. 13: 826, 1991.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Istituto Superiore di Sanità, Laboratorio di Metabolismo e Biochimica Patologica, V.le Regina Elena 299, 00161, Roma, Italy

    A. Olivieri, M. Sorcini, P. Battisti, C. Fazzini, E. Gilardi, Y. Sun, E. Medda, M. Grandolfo &  Salvatore Carta

  2. Ospedale L. Spallanzani, Roma, Italy

    G. Tossini, S. Natili, C. Gioia, P. Narciso & G. Visco

Authors
  1. A. Olivieri
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  2. M. Sorcini
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  3. P. Battisti
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  4. C. Fazzini
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  5. E. Gilardi
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  14. Salvatore Carta
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Olivieri, A., Sorcini, M., Battisti, P. et al. Thyroid hypofunction related with the progression of human immunodeficiency virus infection. J Endocrinol Invest 16, 407–413 (1993). https://doi.org/10.1007/BF03348867

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  • DOI: https://doi.org/10.1007/BF03348867

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