Abstract
The chance of permanent remission after prolonged drug therapy was investigated in 41 patients with toxic multinodular goiter. For purposes of comparison a group of 41 patients with Graves’ disease was also studied. After euthyroidism was achieved all patients received a combination of thionamide and thyroxine for at least 12 months. The minimum follow-up period was 2 yr. Relapse of thyrotoxicosis occurred in 95.1% of patients wfth toxic multinodular goiter and 34.1% of patients with Graves’ disease (p<0.001). It is concluded that for patients with toxic multinodular goiter early radioiodine therapy or surgery is preferred since prolonged druy therapy seldom produces permanent remission.
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van Soestbergen, M.J.M., van der Vijver, J.C.M. & Graafland, A.D. Recurrence of hyperthyroidism in multinodular goiter after long-term drug therapy: A comparison with Graves’ disease. J Endocrinol Invest 15, 797–800 (1992). https://doi.org/10.1007/BF03348807
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DOI: https://doi.org/10.1007/BF03348807