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A case of rheumatoid arthritis associated with silent thyroiditis


A 41-year-old female with rheumatoid arthritis had nontender enlarged thyroid gland. Thyroid function tests revealed increased concentrations of serum free T3 (FT3, 10.8 pmol/L) and free T4 (FT4, 31.1 pmol/L) with suppressed concentration of thyrotropin (TSH, lower than 0.1 mU/L) and low 24-hour thyroidal radioactive iodine uptake (1.6%). Serum thyrotropin receptor antibody (TRAb) was negative (0%) and she had positive anti-thyroglobulin and anti-microsomal antibodies. A diagnosis of silent thyroiditis was made based on laboratory findings. Serum concentrations of FT3 and FT4 normalized one month later without treatment. The causal relationship between the two diseases is discussed.

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Sakata, S., Nagai, K., Shibata, T. et al. A case of rheumatoid arthritis associated with silent thyroiditis. J Endocrinol Invest 15, 377–380 (1992).

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Key words

  • Rheumatoid arthritis
  • hyperthyroidism
  • silent thyroiditis