Abstract
Erythrocyte sodium pump is decreased in hyperthyroid patients. We described the effect of untreated hyperthyroidism on Na+K+ATPase activity, ouabain binding sites and intracellular sodium concentration. We found a reduction in Na+K+ATPase activity and in number of ouabain binding sites with a concomitant increase in intracellular sodium. B-blockade therapy failed to restore normal pump activity and sodium concentration, where only thionamide treatment was successful when it was able to decrease free T3.
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De Riva, C., Chen, S., Virgili, F. et al. Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidism before and after treatment. J Endocrinol Invest 15, 363–367 (1992). https://doi.org/10.1007/BF03348754
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DOI: https://doi.org/10.1007/BF03348754