References
Ritzen E.M. Chemical messengers between Sertoli cells and neighbouring cells. J. Steroid. Biochem. 19:499, 1983.
Sharpe R.M. Paracrine control of the testis. Clin. Endocrinol. Metab. 15:185, 1986.
Saez J.M., Perrard-Sapori M.H., Chatelain P.G., Tabone E., Rivarola M.A. Paracrine regulation of testicular function. J. Steroid Biochem. 27:317, 1987.
Risbridger G.P. de Kretser D.M. Paracrine regulation of the testis. In: Burger H., de Kretser D. (Eds.), The testis. Raven Press, New York, 1989, p. 255.
Skinner M.K. Cell-cell interactions in the testis. Endocr. Rev. 12:45, 1991.
Ritzen E.M., Hansson V., French F.S. The Sertoli cells. In: Burger H., de Kretser D. (Eds.), The testis. Raven Press, New York, 1989, p. 268.
Kerr J.B., Sharpe R.M. Follicle-stimulating hormone induction of Leydig cell maturation. Endocrinology 116:2592, 1985.
Odell W.D., Swerdloff R.S. Etiologies of sexual maturation: a model system based on sexually maturing rat. Rec. Progr. Horm. Res. 32:245, 1976.
Morger W.H. Murphy P.R. Reevaluation of the effect of follicle stimulating hormone on the steroidogenic capacity of the testis: the effect of neuraminidase-treated FSH preparations. Biol. Reprod. 26:422, 1982.
Tabone E., Benahmed M., Reventos J., Saez J.M. Interactions between immature porcine Leydig and Sertoli cells in vitro. Ultrastructural and biochemical study. Cell Tiss. Res. 237:357, 1984.
Perrard-Sapori M.H., Chatelain P., Saez J.M. Modulation of Leydig cell function coculture with pig Sertoli cell or by culture with pig Sertoli cells conditioned medium: effects of insulin, somatomedin-C and FSH. Mol. Cell. Endocrinol. 50:193, 1987.
Verhoeven G. Cailleau J. A factor in spent media from Sertoli cell-enriched cultures that stimulates steroidogenesis in Leydig cells. Mol. Cell. Endocrinol. 40:57, 1985.
Verhoven G. Cailleau J. Specificity and partial purification of a factor in spent media from Sertoli cell-enriched cultures that stimulates steroidogenesis in Leydig cells. J. Steroid Biochem. 25:393, 1986.
Tan A.J., Joseph D.R., Quarmby V.E., Lubahn D.B., Sar M., French F.S., Wilson E.M. The androgen receptor: primary structure, autoreg-ulation of its messenger ribonucleic acid, and im-munocytochemical localization of the receptor protein. Mol. Endocrinol. 2:1276, 1988.
Skinner M.K., Fritz I.B. Androgen stimulation of Sertoli cells is enhanced by peritubular cells. Mol. Cell. Endocrinol. 40:115, 1985.
Skinner M.K., Fetterolf P.M., Anthony C. Purification of a paracrine factor, P-Mod-S, produced by testicular peritubular cells that modulates Sertoli cell function. J. Biol. Chem. 263:2884, 1988.
Bellve’ A.R., Zheng W. Growth factors as autocrine and paracrine modulators of male gonadal functions. J. Reprod. Fert. 85:771, 1989.
Fabbri A., Jannini E.A., Gnessi L., Ulisse S., Moretti C, Isidori A. Neuroendocrine control of male reproductive function. The opioid system as a model of control at multiple sites. J. Steroid Biochem. 32:145, 1989.
Fabbri A., Ulisse S., Bolotti M., Ridolfi M., Spera G., Dufau M.L., Isidori A. Opioid regulation of testicular function. In: Serio M. (Ed.), Perspective in Andrology Serono Symp. Publ. Raven Press, New York, 53:203–213, 1989.
De Kretser D.M., Robertson D.M. The isolation and physiology of inhibin and related proteins. Biology of Reproduction 4: 33, 1989.
Robertson D.M., McLachlan R.I., Burger H.G., de Kretser D.M. Inhibin and inhibin-related proteins in the male. In: H. Burger, D. de Kretser (Eds.), The testis. Raven Press, New York, pag. 231, 1989.
Soder O., Syed V., Pollanen P., Gustaffson K., Granholm K., Khan S., Arver S., Hoist M., von Euler M., Ritzen E. M. Testicular interleukin-l factor. In: Cooke B.A., Sharpe R.M. (Eds.), Molecular and cellular endocrinology of the testis, Serono Symp. Publ., Raven Press, New York, 50:325, 1988.
Guo H., Calkins J.H., Sigel M.M., Lin T. Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis. Endocrinology 727:1234, 1990.
Kasson B.G., Hsueh A.J.W. Arginine vasopressin as an intragonadal hormone in Brattleboro rats: presence of a testicular vaso-pressin-like peptide and functional vasopressin receptors. Endocrinology 118: 23, 1986.
Foo N.C., Carter D., Murphy D., Ivell R. Vasopressin and oxytocin gene expression in rat testis. Endocrinology 723:2118, 1991.
Sharpe R.M., Frazer H.M., Cooper I., Rommerts F.F.G. Sertoli-Leydig cell communications via an LHRH-like factor. Nature 290: 785, 1981.
Tanner J.M., Whitehouse R.H. A note on the bone age at which patients with true isolated growth hormone deficiency enter puberty. J. Clin. Endocrinol. Metab 47:788, 1975.
Laron Z., Sarel R., Hochberg Z., Pertzelan D. In: Cacciari F., Prader A. (Eds)., Pathophysiology of puberty, Serono Symposia vol. 36, Academic Press, London 1980, p. 197.
Kulin, H.E., Samojlik E., Santen R., Santner S. The effect of growth hormone on the Leydig cell response to chronic gonadotropins in boys with hypopituitarism. Clin. Endocrinol. 75:463, 1981.
Darendeliler F., Hindmarsh P.C., Preece M.A., Cox L, Brook C.G.D. Growth hormone increases rate of pubertal maturation. Acta Endocrinol. 722:414, 1990.
Lin T., Blaisdell J., Haskell J.F. Hormonal regulation of type I insulin-like growth factor receptors of Leydig cells in hypophysectomized rats. Endocrinology 123:134, 1988.
Berry S.A., Pescovitz O.H. Identification of a rat GHRH-like substance and its messenger RNA in rat testis. Endocrinology 723:661, 1988.
Pescovitz O.H., Berry S.A., Laudon M., Benjonathan N., Martin-Myers A., Hsu S.M., Lambros T.J., Felix A.M. Localization and growth hormone (Gh)-releasing activity of rat testicular GH-releasing hormone-like peptide. Endocrinology 727:2336, 1990.
D’Ercole A.J., Stiles A.D., Underwood L.E. Tissue concentrations of somatomedin-C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc. Natl. Acad. Sci. U.S.A. 87:935, 1984.
Murphy L.J., Bell G., Friesen H.G. Tissue distribution of insulin-like growth factor I and II messenger ribonucleic acid in the adult rat. Endocrinology 720:1279, 1987.
Closset J., Gothot A., Sente B., Scippo M.L., Igout A., Vandenbroeck M., Dombrowiez D., Hennen G. Pituitary hormones dependent expression of insulinlike growth factor I and II in the immature hypophysectomized rat testis. Mol. Endocrinol. 3:1125, 1989.
Berry S.A., Pescovitz O.H. Ontogeny and pituitary regulation of testicular growth hormone-releasing hormone-like messenger ribonucleic acid. Endocrinology 727:1404, 1990.
Casella S.J., Smith E.P., Van Wyk J.J., Joseph D.R., Hynes M.A., Hoyt E.C., Lund P.K. Isolation of rat testis cDNA encoding an insulin-like growth factor I precursor. DNA 6:325, 1987.
Smith E.P., Svoboda M.E., Van Wyk J.J., Kierszenbaum A.L., Tres L. Partial characterization of a somatomedin-like peptide from the medium of cultured rat Sertoli cells. Endocrinology 720:186, 1987.
Chatelain P.G., Naville D., Saez J.M. Somatomedin-C (insulin-like growth factor l-like material secreted by porcine Sertoli cells in vitro: characterization and regulation. Biochem. Biophys. Res. Commun. 146:1009, 1987.
Lin T., Wang D.L., Calkins J.H., Guo H., Chi R., Housley P.R. Regulation of insulin-like growth factor I messenger ribonucleic acid expression in Leydig cells. Mol. Cell. Endocrinol. 73:147, 1990.
Cailleau J., Vermiere S., Verhoeven G. Independent control of the production of insulin-like growth factor I and its binding protein by cultured testicular cells. Mol. Cell. Endocrinol. 69:79, 1990.
Smith E.P., Dickson B.A., Chernausek S.D. Insulin like growth factor binding protein 3 secretion from cultured rat Sertoli cells: dual regulation by follicle stimulating hormone and insulin-like growth factor I. Endocrinology 727:2744, 1990.
Naville D., Chatelain P.G., Avallet O., Saez J.M. Control of production of insulin-like growth factor I by pig Leydig cells and Sertoli cells cultured alone or together. Cell-cell interactions. Mol. Cell. Endocrinol. 70:217, 1990.
Palmero S., Prati M., Barreca A., Minuto F., Giordano G., Fugassa E. Thyroid hormone stimulates the production of insulinlike growth factor I (IGF-I) by immature rat Sertoli cells. Mol. Cell. Endocrinol. 08:61, 1990.
Hansson H.A., Billig H., Isgaard J. Insulin-like growth factor I in the developing and mature rat testis: immunohistochemical aspects. Biol. Reprod. 40:1321, 1989.
Vannelli B.G., Barni T., Orlando C, Natali A., Serio M., Balboni G.C. Insulin-like growth factor-l (IGF-I) and IGF-I receptor in human testis: a immunohistochemical study. Fertil. Steril. 49:666, 1988.
Baxter R.C., Martin J.L., Handelsman D.J. Identification of human semen insulin-like growth factor l/somatomedin-C immunoreactivity and binding protein. Acta Endocrinol. (Copenh.) 706:40, 1984.
Rosenfeld R.G., Pham H., Oh Y., Lamson G., Giudice L.C. Identification of insulin-like growth factor binding protein 2 (IGF BP 2) and a low molecular weight IGF-BP in human seminal plasma. J. Clin. Endocrinol. Metab. 70:551, 1990.
Barni T., Orlando C, Caldini A.L., Casano R., Chelo E., Forti G., Serio M. Radioimmunoassayable somatomedin-C in seminal plasma of azoospermic patients. Int. J. Androl. 70:457, 1987.
Handelsman D.J., Spaliviero J.A., Scott C.D., Baxter R.C. Identification of insulin-like growth factor I and its receptors in the rat testis. Acta Endocrinol. (Copenh.) 709:543, 1985.
Lin T., Haskell J., Vinson N., Terracio L. Characterization of insulin and insulin-like growth factor 1 receptors of purified Leydig cells and their role in steroidogenesis in primary culture: a comparative study. Endocrinology 119:1641, 1986.
Perrard-Sapori M.H., Chatelain P., Jaillard C, Saez J.M. Characterization and regulation of somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) receptors on cultured pig Leydig cells. Eur. J. Biochem. 765:209, 1987.
Borland K., Mita M., Oppenheimer C.L., Blinderman L.A., Masague J., Hall P.F., Czech M.P. The actions of insulin-like growth factor I and II on cultured Sertoli cells. Endocrinology 114:240, 1984.
Oonk R.B., Grotegoed J.A. Insulin-like growth factor-l receptors on Sertoli cells from immature rats and age-dependent testicular binding of IGF-I and insulin. Mol. Cell. Endocrinol. 55: 33, 1988.
Lin T., Blaisdell J., Haskell J.F. Type I IGF receptors of Leydig cells are upregulated by human chorionic gonadotropin. Biochem. Biophys. Res. Commun. 149:852, 1987.
Tres L, Smith E.P., Van Wyk J.J., Kierszenbaum A.L. Immunoreactive sites and accumulation of so-matomedin-C in rat Sertoli-spermatogenic cell co-cultures. Exp. Cell Res. 162:33, 1986.
De Mellow J.S. M., Handelsman D.J., Baxter R.C. Short term exposure to insulin-like growth factors stimulates testosterone production by testicular interstitial cells. Acta Endocrinol. (Copenh.) 775:483, 1987.
Kasson B. G., Hsueh A.J.W. Insulin-like growth factor-l augments gonadotropin-stimulated androgen biosynthesis by cultured rat testicular cells. Mol. Cell. Endocrinol. 52:27, 1987.
Lin T., Vinson N., Haskell J., Murono E.P. Induction of 3beta-hydroxysteroid dehydrogenase activity by insulin-like growth factor-l in primary culture of purified Leydig cells. Adv. Exp. Med. Biol. 279:603, 1987.
Perrard Sapori M.H., Chatelain P.C., Rogemond N., Saez J.M. Modulation of Leydig cell functions by culture with Sertoli cells or with Sertoli cell conditioned medium: effect of insulin, somatomedin-C and FSH. Mol. Cell. Endocrinol. 50:193, 1987.
Morera A.M., Chauvin M.A., de Peretti E., Binoux M., Benhamed M. Somatomedin-C/Insulin-like growth factor-l: an in-tratesticular differentiative factor of Leydig cells? Horm. Res. 28:50, 1987.
Benhamed M., Morera A.M., Chauvin M.C., de Peretti Somatomedin-C/Insulin-like growth factor I as a possible intratesticular regulator of Leydig cell activity. Mol. Cell. Endocrinol. 50:69, 1987.
Verhoeven G., Cailleau J. Influence of coculture with Sertoli cells on steroidogenesis in immature rat Leydig cells. Mol. Cell. Endocrinol. 77:239, 1990.
Jaillard C, Chatelain P.G., Saez J.M. In vitro regulation of pig Sertoli cell growth and function: effects of fibroblast growth factor and somatomedin-C. Biol. Reprod. 37:665, 1987.
Del Monte P., Takahashi S.I., Van Wyk J.J. Interactions between FSH and IGF-I on DNA synthesis in Sertoli cells from immature rats. 72nd Annual Meeting of the Endocrine Society, Atlanta, GA, USA. Abst. 605.
Saez J.M., Chatelain P.G., Perrard-Sapori M.H., Jaillard C, Naville D. Differentiating effects of somatomedin-C/Insulin-like growth factor I and insulin on Leydig and Sertoli cells functions. Reprod. Nutr. Dev. 28:989, 1988.
Eartlett J.M.S., Spiteri-Grech J., Nieschlag E. Regulation of insulin-like growth factor I and stage-specific levels of epidermal growth factor in stage synchronized rat testes. Endocrinology 727:747, 1990.
Tsutsumi O., Kurachi H., Oka T. A physiological role of epidermal growth factor in male reproductive function. Science 233: 975, 1986.
Elson S.D., Browne C.A., Thorburn G.D. Identification of epidermal growth factor-like activity in human male reproductive tissues and fluids. J. Clin. Endocrinol. Metab. 58:589, 1984.
Holmes S.D., Spotts G., Smith R.G. Rat Sertoli cells secrete a growth factor that blocks epidermal growth factor (EGF)binding to its receptor. J. Biol. Chem. 267:4076, 1986.
Skinner M.K., Takacs K., Coffey R.J. Transforming growth factor alpha gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions. Endocrinology 724:845, 1989.
Teerds K.J., Rommerts F.F., Dorrington J.H. Immunohistochemical detection of transforming growth factor-alpha in Leydig cells during the development of the rat testis. Mol. Cell. Endocrinol. 69: R1–6, 1990.
Sordoillet C, Chauvin M.A., De Peretti E., Morera A.M., Benhemed M. Epidermal growth factor directly stimulates steroidogenesis in primary cultures of porcine Leydig cells: actions and sites of action. Endocrinology 728:2160, 1991.
Welsh T.H., Hsueh A.J.W. Mechanism of the inhibitory action of epidermal growth factor on testicular androgen biosynthesis in vitro. Endocrinology 110: 1498, 1982.
Verhoeven G., Cailleau J. Stimulatory effects of epidermal growth factor on steroidogenesis in Leydig cells. Mol. Cell. Endocrinol. 49:99, 1986.
Skinner M.K., Moses H.L. Transforming growth factor beta gene expression and actions in the seminiferous tubule: peritubular cell-Sertoli cell interactions. Mol. Endocrinol. 3:625, 1989.
Bart C, Fauser J. M., Hsueh J.W. Effect of transforming growth factor beta on human chorionic gonadotropin induced testosterone production by cultured rat testicular cells. Life Sci. 43:1363, 1988.
Benhamed M., Esposito G., Sordoillet C., de Peretti E., Chauvin M.A., Ghiglieri C, Revol A., Morera A.M. Transforming growth factor beta and its related peptides in the testis: an intragonadal polypeptide control system. In: Serio M. (Ed.), Perspective in andrology. Raven Press, New York, Serono Symp. Publ. 53:191, 1989.
Esposito G., Keramidas M., Mauduit, Feige J.J., Morera A.M., Benahmed M. Direct regulating effects of transforming growth factor-beta 1 on lactate production in cultured porcine Sertoli cells. Endocrinology 128:1441, 1991.
Nargolwalla C, McCabe D., Fritz I.B. Modulation of levels of messenger RNA for tissue-type plasminogen activator in rat Sertoli cells, and levels of messenger RNA for plasminogen activator inhibitor in testis peritubular cells. Mol. Cell. Endocrinol. 70:73, 1990.
Ueno N., Baird A., Esch F., Ling N., Guillemin R. Isolation and partial characterization of basic fibroblast growth factor from bovine testis. Mol. Cell. Endocrinol. 49:189, 1987.
Story M.T., Sasse J., Kakuska D., Jacobs S.C., Lawson R.K. A growth factor in bovine and human testes structurally related to basic fibroblast growth factor. J. Urol. 140:422, 1988.
Smith E.P., Hall S., Monaco L, French F., Wilson E.M., Conti M. A rat Sertoli cell factor similar to basic fibroblast growth factor increases c-fos messenger ribonucleic acid in cultured Sertoli cells. Mol. Endocrinol. 3:958, 1989.
Boockfor F.R., Schwarz L.K. Fibroblast growth factor modulates the release of transferrin from cultured Sertoli cells. Mol. Cell. Endocrinol. 73:187, 1990.
Fauser B.C., Baird A., Husueh A.J. Fibroblasts growth factor inhibits luteinizing hormone stimulated androgen production by cultured rat testicular cells. Endocrinology 723:2935, 1990.
Murono E.P., Washburn A.L. Fibroblast growth factor inhibits of 5-alpha reductase activity in cultured immature Leydig cells. Mol. Cell. Endocrinol. 68: R 19–23, 1990.
Murono E.P., Washburn A.L. Basic fibroblast growth factor inhibits delta 5-3 beta hydroxysteroid dehydrogenase-isomerase activity in cultured immature Leydig cells. Biochem. Biophys. Res. Commun. 168:248, 1990.
Raeside J.I., Berthelon M.C., Sanchez P., Saez J.M. Stimulation of aromatase activity in immature porcine Leydig cells by fibroblast growth factor (FGF). Biochem. Biophys. Res. Commun. 151:163, 1988.
Olson L., Ayer-LeLievre C., Ebendal T., Seiger A. Nerve growth factor-like immunoreactivities in rodent salivary glands and testes. Cell. Tissue Res. 248: 275, 1987.
Ayer-LeLievre C., Olson L., Ebendal T., Hallbook F., Persson H. Nerve growth factor mRNA and protein in the testis and epididimis of the mouse and rat. Proc. Natl. Acad. Sci. U.S.A. 35:2628, 1988.
Persson H., Ayer-LeLievre C., Soder O., Villar M.J., Metsis M., Olson L., Ritzen M., Hokfelt T. Expression of beta nerve growth factor receptor mRNA in Sertoli cells downregulated by testosterone. Science 247: 704, 1990.
Seidl K., Holstein A.F. Organ culture of human seminiferous tubules: a useful tool to study the role of nerve growth factor in the testis. Cell Tissue Res. 261:539, 1990.
Seidl K., Holstein A.F. Evidence for the presence of nerve growth factor (NGF) and NGF receptors in human testis. Cell Tissue Res. 261: 549, 1990.
Feig L.A., Klagsbrun M., Bellvé A.R. Mitogenic polypeptide of the mammalian seminiferous epithelium. Biochemical characterization and partial purification. J. Cell Biol. 97:1435, 1983.
Braunhut S.J., Rufo G.A., Ernisee B.J., Zheng B.J., Bellvé A.R. The seminiferous growth factor induces proliferation of TM4 cells in serum free medium. Biol. Reprod. 42:639, 1990.
Zheng W.X., Butwell T.J., Heckert L., Griswold M.D., Bellvé A.R. Pleiotypic actions of the seminiferous growth factor on two testicular cell lines: comparison with acidic and basic fibroblasts growth factors. Growth factors 3: 73, 1990.
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This work was supported by research grants from Consiglio Nazionale delle Ricerche n. 88.01970.04, 89.04176.04, 89.00188.70.
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Giordano, G., Del Monte, P. & Minuto, F. Growth factors and testis. J Endocrinol Invest 15, 67–75 (1992). https://doi.org/10.1007/BF03348665
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DOI: https://doi.org/10.1007/BF03348665