Skip to main content
SpringerLink
Log in

Influence of estrogens on calcitonin secretion

  • Short Communication
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

In this study we investigated the calcitonin (CT) pattern both in basal conditions and after calcium infusion before and one month after oophorectomy in 17 premenopausal women. In addition, 13 oophorectomized women were randomly allocated to two groups, one given hormone replacement treatment and the other untreated, and CT response to hypercalcemia was reevaluated one year later. CT response to calcium infusion was significant only before oophorectomy and one year after estrogen-progestogen treatment, whereas there was no response one month after oophorectomy or after one year without hormone replacement therapy. Our data indicate that both estrogen secretion and replacement treatment may be important factors in CT response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Lindsay R., Hart D.M., Forrest C, Baird C. Prevention of spinal osteoporosis in oophorectomized women. Lancet 2:1151, 1980.

    Article  CAS  PubMed  Google Scholar 

  2. Christiansen C, Christensen M.S., Transbol I. Bone mass in postmenopausal women after withdrawal of oestrogen-gestagen replacement therapy. Lancet 7; 459, 1981.

    Article  Google Scholar 

  3. Aitken J.M., Hart D.M., Anderson J.B., Lindsay R., Smith D.A., Speirs CF. Osteoporosis after oophorectomy for non-malignant disease in premenopausal women. Br. Med. J. 2:235, 1973.

    Article  Google Scholar 

  4. Eriksen E.F., Colvard D.S., Berg N.J., Graham M.L., Mann K.G., Spelsberg T.C., Riggs B.L. Evidence of oestrogen receptors in normal human osteoblast-like cells. Science 241: 84, 1988.

    Article  CAS  PubMed  Google Scholar 

  5. Stevenson J.C., Abeyasekera G., Hillyard C.J., Phang K.G., MacIntyre I., Campbell S., Young O., Towsend P.T., Whitehead M.I. Calcitonin and the calcium regulating hormones in postmenopausal women: effect of estrogens. Lancet 1: 693, 1981.

    Article  CAS  PubMed  Google Scholar 

  6. Civitelli R., Agnusdei D., Nardi P., Zacchei F., Avioli L.V., Gennari C. Effects of one-year treatment with estrogens on bone mass, intestinal calcium absorption and 25-hydroxy-vitamin D-1 alpha hydroxylase reserve in postmenopausal osteoporosis. Calcif. Tissue Int. 42:77, 1988.

    Article  CAS  PubMed  Google Scholar 

  7. Greenberg C, Kukreja S.C., Bowser E.N., Hargis G.K., Henderson W.J., Williams G.A. Effects of estradiol and progesterone on calcitonin secretion. Endocrinology 118:2594, 1986.

    Google Scholar 

  8. Hillyard C.J., Mac Intyre I., Stevenson J.C. Relative deficiency of plasma calcitonin in normal women. Lancet 2:961, 1978.

    Article  Google Scholar 

  9. Withehead M., Lange G., Young O., Campbell S., Abeyasekera G., Hillyard C.J., Mac Intyre I., Phang K.G. Interrelations of calcium regulating hormones during normal pregnancy. Br. Med. J. 282:10, 1981.

    Article  Google Scholar 

  10. Zsely J., Szucs J., Steczek K., Szathmari M., Kollin CS., Horvath C.S., Garth M., Hollo I. Decrease of calcitonin reserve in accelerated postmenopausal osteoporosis. Horm. Metab. Res. 77:696, 1985.

    Article  Google Scholar 

  11. Morimoto S., Tsiyi M., Okada Y., Owishi T., Kumahara Y. The effects of oestrogens on human calcitonin secretion after calcium infusion in elderly female subjects. Clin. Endocrinol. (Oxf.) 13:135, 1980.

    Article  CAS  Google Scholar 

  12. Isaia G.C., Campagnoli C, Mussetta M., Massobrio M., Salamano G., Gallo M., Molinatti G.M. Calcitonin and lumbar bone mineral content during oestrogen-progestogen administration in postmenopausal women. Maturitas 11:287, 1989.

    Article  CAS  PubMed  Google Scholar 

  13. Agnusdei D., Civitelli R., Camporeale A., Gennari C. Calcitonin and estrogens. J. Endocrinol. Invest. 73:625, 1990.

    Google Scholar 

  14. Emmertsen K., Marquersen J., Jensen F.F., Hansen H.H. Radioimmunoassay of calcitonin in unextracted human serum: a sensitive method. Scand. J. Clin. Lab. Invest. 42:539, 1982.

    Article  CAS  PubMed  Google Scholar 

  15. Reginster J.Y., Deroisy R., Albert A., Denis D., Lecart M.P., Collette J., Franchimont P. Relationship between whole plasma calcitonin secretory capacity and plasma levels of estrone in healthy women and postmenopausal osteoporosis. J. Clin. Invest. 83: 1073, 1989.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Lobo RA, Roy S., Shoupe D., Endres D.B., Adams J.S., Rude R.R., Singer F.R. Estrogen and progestin effects on urinary calcium and calciotropic hormones in surgically induced post-menopausal women. Horm. Metab. Res. 77:370, 1985.

    Article  Google Scholar 

  17. Gallagher J.C, Riggs B.L., Jerpbak C. M., Arnaud C.D. The effect of age on serum immunoreactive parathy roid hormone in normal and osteoporotic women. J. Lab. Clin. Med. 95:373, 1980.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Medicina Interna, Clinica Medica B, Università di Torino, Corso A.M. Dogliotti 14, 10126, Torino, Italy

    Giancarlo Isaia M.D., M. Mussetta, A. Sciolla & G. M. Molinatti

  2. Clinica Ostetrica e Ginecologica D, Università di Torino, Torino, Italy

    M. Massobrio & M. Gallo

Authors
  1. Giancarlo Isaia M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Mussetta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Massobrio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Sciolla
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Gallo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. M. Molinatti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Isaia, G., Mussetta, M., Massobrio, M. et al. Influence of estrogens on calcitonin secretion. J Endocrinol Invest 15, 59–62 (1992). https://doi.org/10.1007/BF03348663

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03348663

Key-words

Search

Navigation