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Inhibitory effects of centrally administered |ASU1–7| eel calcitonin on basal and stimulated prolactin release in rats

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Abstract

We investigated the effects of /ASU1–7/eel calcitonin (ASU1–7 elCT) on basal and stimulated prolactin (PRL) release in male rats. /ASU1–7/eelCT was administered intracerebroventricularly (icv) into freely moving rats with indwelling catheters. The administration of /ASU1–7/eelCT (2.5 μ/rat, icv) significantly inhibited basal PRL secretion. When PRL secretion was stimulated by exposing rats to restraint stress, /ASU1–7/eelCT (250 ng; 800 ng; 2.5 μ/rat, icv) dose-relatedly inhibited the PRL surges at 10 min after stress. The same doses of icv /ASU1–7/eelCT were effective in inhibiting morphine (6 mg/kg, intracarotid, ia)-induced PRL release. No effect on stress-induced PRL secretion was observed when the peptide was administered intracarotid at the dose of 10 μ/rat. These results demonstrate that /ASU1–7/eelCT, as we previously observed with salmon calcitonin (sCT), has central inhibitory activity on PRL secretion, probably through enhancement of hypothalamic inhibitory pathways involved in the control of PRL.

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Authors and Affiliations

  1. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy

    V. Sibilia M.D., C. Netti, F. Guidobono, I. Villa & A. Pecile

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  1. V. Sibilia M.D.
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  2. C. Netti
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  3. F. Guidobono
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  4. I. Villa
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  5. A. Pecile
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Sibilia, V., Netti, C., Guidobono, F. et al. Inhibitory effects of centrally administered |ASU1–7| eel calcitonin on basal and stimulated prolactin release in rats. J Endocrinol Invest 13, 507–511 (1990). https://doi.org/10.1007/BF03348612

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  • DOI: https://doi.org/10.1007/BF03348612

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