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Chronic treatment with a long-acting somatostatin analogue in a patient with intestinal carcinoid tumor: occurence of cholelithiasis


The long-acting somatostatin analogue SMS 201-995 has been used efficaciously in the therapy of metastatic carcinoid tumor, vasoactive intestinal peptide producing islet cell carcinoma, acromegaly, and TSH secreting pituitary tumors. We report the development of a gallstone in a patient treated for 23 months with a long acting somatostatin analogue for a metastatic carcinoid tumor. Symptomatic improvement and a reduction in the urinary excretion of 5-hydroxyin-doleacetic acid occurred. There was no evidence of a gallstone on ultrasound and CT scan of the abdomen prior to somatostatin therapy. A progressively enlarging, asymptomatic gallstone developed during therapy.

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Corresponding author

Correspondence to Elio Roti.

Additional information

This work was supported in part by grant 85.00533.04,86.00134.04 and 88.00628.04 from Consiglio Nazionale delle Ricerche, Rome, by grant “Patologia delta Tiroide. Indagine dei Fattori Etiopatogenetici” of Ministero Pubblica Istruzione 40%, Rome, Italy, by grant DK-19819 from NIDDK, NIH, Bethesda, MD, and by NATO grant RG. 85/0696.

Dr. Eliana Gardini is a recipient of a fellowship from Associazione Volontaria Promozione Ricerca Tumori (A.VO.PRO.RI.T.), Parma, Italy.

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Roti, E., Minelli, R., Gardini, E. et al. Chronic treatment with a long-acting somatostatin analogue in a patient with intestinal carcinoid tumor: occurence of cholelithiasis. J Endocrinol Invest 13, 69–72 (1990).

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  • Carcinoid tumor
  • SMS 201-995
  • cholelithiasis